Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sodium channel protein

Gene

scn8ab

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

  • voltage-gated ion channel activity Source: UniProtKB-KW
  • voltage-gated sodium channel activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:scn8abImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-060906-2 scn8ab

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei130 – 153HelicalUniRule annotationAdd BLAST24
Transmembranei256 – 276HelicalUniRule annotationAdd BLAST21
Transmembranei350 – 368HelicalUniRule annotationAdd BLAST19
Transmembranei389 – 416HelicalUniRule annotationAdd BLAST28
Transmembranei727 – 745HelicalUniRule annotationAdd BLAST19
Transmembranei757 – 775HelicalUniRule annotationAdd BLAST19
Transmembranei837 – 865HelicalUniRule annotationAdd BLAST29
Transmembranei927 – 950HelicalUniRule annotationAdd BLAST24
Transmembranei1174 – 1192HelicalUniRule annotationAdd BLAST19
Transmembranei1213 – 1232HelicalUniRule annotationAdd BLAST20
Transmembranei1244 – 1264HelicalUniRule annotationAdd BLAST21
Transmembranei1290 – 1316HelicalUniRule annotationAdd BLAST27
Transmembranei1413 – 1439HelicalUniRule annotationAdd BLAST27
Transmembranei1498 – 1516HelicalUniRule annotationAdd BLAST19
Transmembranei1528 – 1550HelicalUniRule annotationAdd BLAST23
Transmembranei1562 – 1581HelicalUniRule annotationAdd BLAST20
Transmembranei1625 – 1650HelicalUniRule annotationAdd BLAST26
Transmembranei1718 – 1741HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliQ20JQ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 422Ion_transInterPro annotationAdd BLAST290
Domaini495 – 673Na_trans_cytoplInterPro annotationAdd BLAST179
Domaini727 – 954Ion_transInterPro annotationAdd BLAST228
Domaini964 – 1167Na_trans_assocInterPro annotationAdd BLAST204
Domaini1172 – 1447Ion_transInterPro annotationAdd BLAST276
Domaini1497 – 1751Ion_transInterPro annotationAdd BLAST255

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili413 – 451Sequence analysisAdd BLAST39

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG410XNP6 LUCA
HOGENOMiHOG000231755
HOVERGENiHBG053100
KOiK04840
PhylomeDBiQ20JQ3

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR008054 Na_channel_a8su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit
PRINTSiPR00170 NACHANNEL
PR01667 NACHANNEL8

Sequencei

Sequence statusi: Complete.

Q20JQ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPLLAPPG PDSFKRFTLE SLANIEKRIA EEKKKKPVKP RSDSSHRDDD
60 70 80 90 100
DDNKPKPNSD LEAGKGVPFI YGDVPSNMLA VPLEDLDPFY LNKKTFIVLN
110 120 130 140 150
KGKTIFRFSA TPSLYIISPF NLFRQIAIKI LIHSFFSMII MCTILTNCVF
160 170 180 190 200
MTFSNPPEWS KQVEYTFTGI YTFESLTKIV ARGFCIDDFT FLRDPWNWLD
210 220 230 240 250
FMVISMAYVT EFVDLGNVSA LRTFRVLRAL KTISVIPRLK TIVGALIQSV
260 270 280 290 300
KKLSDVMILT VFCLSVFALI GLQLFMGNLR QKCVIWPVNS TETYLANGSK
310 320 330 340 350
GFDFNEYIMN DTNFYFLPGM LDALLCGNSS DSGRCPEGYT CMKAGRNPNY
360 370 380 390 400
GYTSFDSFGW AFLALFRLMT QDFWENLYQL TLRAAGKTYM IFFVLVIFVG
410 420 430 440 450
SFYLVNLILA VVAMAYEEQN QATIEEAEQK EAEFKAMLEQ LKKQQEEAQA
460 470 480 490 500
NAMATSAGTV SEDAVEDDGG GHLSRSSSEV SKLSSKSAKE RRNRKKKWRK
510 520 530 540 550
EQEEKGDSEK VVKSESDDGS KRSRFRFRDN RLGRKASIMN QSLLSIPGSP
560 570 580 590 600
FMSRRSSIFS FKGSENEFAD DEHSTVEESE DRRGSLFVPY RRSSYSGYSQ
610 620 630 640 650
GSSRINPLAP HPGCKRNSTV DCNGVVSLIG PGPGRLLPET TEVEGKRKHS
660 670 680 690 700
GSLMVSVDQL NTSFSRKERA NSAMTVVTNT LVEELEESQR KCPPCWYKFA
710 720 730 740 750
NTFLIWECCP IWIKIKEIVN LIVMDPFVDL AITICIVLNT VFMAMEHYPM
760 770 780 790 800
TPRFEEVLSV GNLVFTGIFT AEMFAKLIAM DPYYYFQEGW NIFDGFIVSL
810 820 830 840 850
SLVELGLADV EGLSVLRSFR LLRVFKLAKS WPTLNMLIKI IGNSVGALGN
860 870 880 890 900
LTLVLAIIVF IFAVVGMQLF GKSYKDCVCK IAESCELPRW HMNDFFHSFL
910 920 930 940 950
IVFRVLCGEW IETMWDCMEV AGQSMCLIVF MMVMVIGNLV VLNLFLALLL
960 970 980 990 1000
SSFSADNLAA TDDDGEMNNL QISVIRIKKG IAWFKIHVRL LVAHVLKKKP
1010 1020 1030 1040 1050
LEDEDKPLDD MYDKKLNLMG NHTGVEIKCG DLNYPKNGNG TTSGIGSSVG
1060 1070 1080 1090 1100
KYMIDEEPMS FIHNPNLTVR VPIAVGGSDF ENLNTEDFSS ESDVENSKDL
1110 1120 1130 1140 1150
DDTSSSEGST IDIKPDEEEM AVVEVVEEYL DPEACWTDAC VARYKCCDVP
1160 1170 1180 1190 1200
ITEGWGKYWW FLRKTCYLIV EHNWFETLII FMILLSSGAL AFEDVYIEQR
1210 1220 1230 1240 1250
KTIQIILEYA DRVFTYIFIL EMLLKWVAYG FVKYFTNAWC WLDFFIVDVS
1260 1270 1280 1290 1300
IVSLIANALG YSDLGPIKSL RTLRALRPLR ALSRFEGMRV VVNALVGAIP
1310 1320 1330 1340 1350
SIMNVPLVCL IFWLIFSIMG VNLFAGKYYY CFNQTAEEYF QVDVVNNKTE
1360 1370 1380 1390 1400
CFALINANYT EVRWKNVKIN FDNVGAGYLA LLQVATFKGW MDIMYAAVDS
1410 1420 1430 1440 1450
RKVEDQPLYE DNIYMYIYFV IFIIFGSFFT LNLFIGVIID NFNQQKKKFG
1460 1470 1480 1490 1500
GQDIFMPEEQ KKYYNAMKKL GSKKPQKPIP RPLNKIQGMV FDFVTQQAFD
1510 1520 1530 1540 1550
ISIMMLICLN MVTMMVETDD QSDETENILY WINFVFIVAF TGEFVLKLFA
1560 1570 1580 1590 1600
LRHYYFTNGW NVFDCVVVIL SIVGMFLADL IEKYFVSPTL FRVIRLARIG
1610 1620 1630 1640 1650
RILRLIKGAK GIRTLLFALM MSLPALFNIG LLLFLVMFIF SIFGMSNFAY
1660 1670 1680 1690 1700
VKREIGIDDM YNFETFGNSM ICLFMITTSA GWDGLLAPIL NYPPDCDPNK
1710 1720 1730 1740 1750
ENPGTTVKGN CGNPSVGIFF FVMYIIVSFL IVVNMYIAII LENFSVATEE
1760 1770 1780 1790 1800
SADPLCEDDF ESFYEIWEKF DPDASQFITF AKLPDFADTL EHPLRVPKPN
1810 1820 1830 1840 1850
IIELIAMDLP MVSGDRIHCL DILFAFTKRV LGDSGDLDMM RQQMEERFVA
1860 1870 1880 1890 1900
ANPSKVSYEP ITTTLRRKQE EVSAIVIQRS YRSHLASRGF ICKRRPANNK
1910 1920 1930 1940 1950
LENGGGNQEK KEGTPSTASL PSYDSVTKPE KEKQDDNNEG KGRKEKGRNQ

KDVRESKC
Length:1,958
Mass (Da):222,546
Last modified:April 18, 2006 - v1
Checksum:i47754D24E5B0DB11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ149509 mRNA Translation: ABA54924.1
RefSeqiNP_001038648.1, NM_001045183.1
UniGeneiDr.87506

Genome annotation databases

GeneIDi793996
KEGGidre:793996

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ149509 mRNA Translation: ABA54924.1
RefSeqiNP_001038648.1, NM_001045183.1
UniGeneiDr.87506

3D structure databases

ProteinModelPortaliQ20JQ3
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi793996
KEGGidre:793996

Organism-specific databases

CTDi793996
ZFINiZDB-GENE-060906-2 scn8ab

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG410XNP6 LUCA
HOGENOMiHOG000231755
HOVERGENiHBG053100
KOiK04840
PhylomeDBiQ20JQ3

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR008054 Na_channel_a8su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit
PRINTSiPR00170 NACHANNEL
PR01667 NACHANNEL8
ProtoNetiSearch...

Entry informationi

Entry nameiQ20JQ3_DANRE
AccessioniPrimary (citable) accession number: Q20JQ3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 18, 2006
Last modified: November 7, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again