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Entry version 132 (08 May 2019)
Sequence version 4 (22 Jul 2008)
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Protein

Signal transducer and activator of transcription b

Gene

sta-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Carries out a dual function: signal transduction and activation of transcription (By similarity). By regulating the up-regulation in the epidermis of antimicrobial peptides nlp-29, plays a role in resistance to fungal infection and in the response to physical wounding and phorbol ester PMA treatment (PubMed:22470487).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-1059683 Interleukin-6 signaling
R-CEL-1169408 ISG15 antiviral mechanism
R-CEL-1251985 Nuclear signaling by ERBB4
R-CEL-1266695 Interleukin-7 signaling
R-CEL-186763 Downstream signal transduction
R-CEL-2586552 Signaling by Leptin
R-CEL-3249367 STAT6-mediated induction of chemokines
R-CEL-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-CEL-6783783 Interleukin-10 signaling
R-CEL-6785807 Interleukin-4 and Interleukin-13 signaling
R-CEL-877300 Interferon gamma signaling
R-CEL-877312 Regulation of IFNG signaling
R-CEL-8854691 Interleukin-20 family signaling
R-CEL-8983432 Interleukin-15 signaling
R-CEL-8984722 Interleukin-35 Signalling
R-CEL-8985947 Interleukin-9 signaling
R-CEL-9008059 Interleukin-37 signaling
R-CEL-9020558 Interleukin-2 signaling
R-CEL-9020591 Interleukin-12 signaling
R-CEL-9020933 Interleukin-23 signaling
R-CEL-9020956 Interleukin-27 signaling
R-CEL-909733 Interferon alpha/beta signaling
R-CEL-982772 Growth hormone receptor signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Signal transducer and activator of transcription b
Alternative name(s):
Zinc finger protein STAT-B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sta-2Imported
Synonyms:stat-bImported
ORF Names:F58E6.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
F58E6.1 ; CE42515 ; WBGene00010251 ; sta-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002341041 – 567Signal transducer and activator of transcription bAdd BLAST567

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q20977

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q20977

PeptideAtlas

More...
PeptideAtlasi
Q20977

PRoteomics IDEntifications database

More...
PRIDEi
Q20977

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00010251 Expressed in 3 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.F58E6.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini449 – 548SH2PROSITE-ProRule annotationAdd BLAST100

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the transcription factor STAT family.Sequence analysis

Keywords - Domaini

SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1609 Eukaryota
COG5183 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182688

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q20977

Identification of Orthologs from Complete Genome Data

More...
OMAi
NGEIRHH

Database of Orthologous Groups

More...
OrthoDBi
327469at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q20977

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.630, 1 hit
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR013801 STAT_TF_DNA-bd
IPR012345 STAT_TF_DNA-bd_N

The PANTHER Classification System

More...
PANTHERi
PTHR11801 PTHR11801, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02864 STAT_bind, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49417 SSF49417, 1 hit
SSF55550 SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50001 SH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q20977-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSVVSDQMD IESSSAFSPA EPVVDGAFVS KHNLSAEAYQ GFKECADSLL
60 70 80 90 100
SGKIAQNEQL PFIQRTLQIC ENVILNFEDE KQHLMSDVLL VWAMKQQKLS
110 120 130 140 150
IATLHTQQLH YKELDLINLQ FEYFGELLQQ TLSGLDYLKQ YYPNVGFEEV
160 170 180 190 200
HSKVRNLTHY FLYYSIIVSR QPPSVIVKCG EAENHRRSRF WFNTEIRILG
210 220 230 240 250
GSAFGIDTNN ENSNVNCYLI TDETAKQLLN NAYLDIFESE EFCIEPNTST
260 270 280 290 300
FQKKDARGIK AKFDDMKVAK KVALRRDSVA TKRYCLCYNI QLQTNCGIEL
310 320 330 340 350
VGKKVSLPFA VLVGPKADVE AKLFLERSFA DLVRHPLSDI PTHVSCAEMA
360 370 380 390 400
DALEMKFQAI IETPQKNTDG PSVVQPRKFN MQTKQHLVMR MKPNNQGFLP
410 420 430 440 450
LDNFMKLPVA EEFQHKKSAS AEGDWKLVPF YDWFFKLAEI TNKYLYSMWY
460 470 480 490 500
DGLVYGFCSK EDAENILRCI PRSVLLVRFS DIEYGKIKIS VKNRNGEIRH
510 520 530 540 550
HWYEHADLNA RSLNSELLSN HKFSDVDLIY PDIDLEVALG GRNKPRIRLP
560
RNLAPDEIYF DNQGAAT
Length:567
Mass (Da):65,018
Last modified:July 22, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i69DBBDE560D10A82
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD45535 differs from that shown. Intron retention.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF164113 mRNA Translation: AAD45535.1 Sequence problems.
Z70754 Genomic DNA Translation: CAQ35047.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T22925

NCBI Reference Sequences

More...
RefSeqi
NP_001122963.1, NM_001129491.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F58E6.1; F58E6.1; WBGene00010251

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3565291

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F58E6.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164113 mRNA Translation: AAD45535.1 Sequence problems.
Z70754 Genomic DNA Translation: CAQ35047.1
PIRiT22925
RefSeqiNP_001122963.1, NM_001129491.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi6239.F58E6.1

Proteomic databases

EPDiQ20977
PaxDbiQ20977
PeptideAtlasiQ20977
PRIDEiQ20977

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF58E6.1; F58E6.1; WBGene00010251
GeneIDi3565291
KEGGicel:CELE_F58E6.1

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3565291
WormBaseiF58E6.1 ; CE42515 ; WBGene00010251 ; sta-2

Phylogenomic databases

eggNOGiKOG1609 Eukaryota
COG5183 LUCA
GeneTreeiENSGT00950000182688
InParanoidiQ20977
OMAiNGEIRHH
OrthoDBi327469at2759
PhylomeDBiQ20977

Enzyme and pathway databases

ReactomeiR-CEL-1059683 Interleukin-6 signaling
R-CEL-1169408 ISG15 antiviral mechanism
R-CEL-1251985 Nuclear signaling by ERBB4
R-CEL-1266695 Interleukin-7 signaling
R-CEL-186763 Downstream signal transduction
R-CEL-2586552 Signaling by Leptin
R-CEL-3249367 STAT6-mediated induction of chemokines
R-CEL-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-CEL-6783783 Interleukin-10 signaling
R-CEL-6785807 Interleukin-4 and Interleukin-13 signaling
R-CEL-877300 Interferon gamma signaling
R-CEL-877312 Regulation of IFNG signaling
R-CEL-8854691 Interleukin-20 family signaling
R-CEL-8983432 Interleukin-15 signaling
R-CEL-8984722 Interleukin-35 Signalling
R-CEL-8985947 Interleukin-9 signaling
R-CEL-9008059 Interleukin-37 signaling
R-CEL-9020558 Interleukin-2 signaling
R-CEL-9020591 Interleukin-12 signaling
R-CEL-9020933 Interleukin-23 signaling
R-CEL-9020956 Interleukin-27 signaling
R-CEL-909733 Interferon alpha/beta signaling
R-CEL-982772 Growth hormone receptor signaling

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q20977

Gene expression databases

BgeeiWBGene00010251 Expressed in 3 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di2.60.40.630, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR013801 STAT_TF_DNA-bd
IPR012345 STAT_TF_DNA-bd_N
PANTHERiPTHR11801 PTHR11801, 1 hit
PfamiView protein in Pfam
PF02864 STAT_bind, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTATB_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q20977
Secondary accession number(s): B2D6L5
, Q20978, Q95ZS4, Q9U9L4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 22, 2008
Last modified: May 8, 2019
This is version 132 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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