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Protein

Methionine--tRNA ligase, cytoplasmic

Gene

mars-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei370ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase, RNA-binding, tRNA-binding
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine--tRNA ligase, cytoplasmic (EC:6.1.1.10)
Alternative name(s):
Methionyl-tRNA synthetase
Short name:
MetRS
Gene namesi
Name:mars-1Imported
Synonyms:mrs-1Imported
ORF Names:F58B3.5Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF58B3.5a ; CE06007 ; WBGene00003415 ; mars-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001392651 – 917Methionine--tRNA ligase, cytoplasmicAdd BLAST917

Proteomic databases

EPDiQ20970
PaxDbiQ20970
PeptideAtlasiQ20970
PRIDEiQ20970

PTM databases

iPTMnetiQ20970

Expressioni

Gene expression databases

BgeeiWBGene00003415 Expressed in 5 organ(s), highest expression level in adult organism

Interactioni

Protein-protein interaction databases

STRINGi6239.F58B3.5a

Structurei

3D structure databases

ProteinModelPortaliQ20970
SMRiQ20970
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini756 – 857tRNA-bindingAdd BLAST102

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi44 – 54"HIGH" regionAdd BLAST11
Motifi367 – 371"KMSKS" region5

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1247 Eukaryota
KOG2241 Eukaryota
COG0073 LUCA
COG0143 LUCA
GeneTreeiENSGT00550000075017
HOGENOMiHOG000200402
InParanoidiQ20970
KOiK01874
OMAiVCKNTPH
OrthoDBiEOG091G020Y
PhylomeDBiQ20970

Family and domain databases

CDDicd00814 MetRS_core, 1 hit
Gene3Di2.20.28.20, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00098 Met_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR023458 Met-tRNA_ligase_1
IPR014758 Met-tRNA_synth
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR033911 MetRS_core
IPR029038 MetRS_Zn
IPR012340 NA-bd_OB-fold
IPR014729 Rossmann-like_a/b/a_fold
IPR002547 tRNA-bd_dom
IPR009080 tRNAsynth_Ia_anticodon-bd
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PF01588 tRNA_bind, 1 hit
PRINTSiPR01041 TRNASYNTHMET
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50249 SSF50249, 1 hit
SSF57770 SSF57770, 1 hit
TIGRFAMsiTIGR00398 metG, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit
PS50886 TRBD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q20970-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGHDLADIKK SFEASLPGYV EKKDPKSILP QPGKRNILIT AALPYVNNVP
60 70 80 90 100
HLGNIIGCVL SADVFARYCN LRGHQTFYVG GTDEYGTATE TKALQEGCTP
110 120 130 140 150
RELCDKYHAI HKGIYEWFGI DFSHFGRTTT DHQTEICQDM FLKLHKNGYT
160 170 180 190 200
SSQSVDQLYC NQCEKFLADR FVTGTCPMCA YDDARGDQCD GCGKLINAVD
210 220 230 240 250
LKDAKCHMCK ATPEVKQSTH IFLSLDKLQQ KTTEHLDREL AKEDNRWSSN
260 270 280 290 300
AVGITKAWMK LGLDPRCITR DLKWGTAVPL DGFEKKVFYV WFDAPIGYLS
310 320 330 340 350
ITKCVLGDNW TKWWKNPENV ELFNFVGKDN VAFHAVMFPC SQLGANDNYT
360 370 380 390 400
VVNNLCATEY LNYEDTKFSK SRGTGIFGDA AQGTEIPADI WRFYLLYMRP
410 420 430 440 450
ESQDTAFSWD DFVLKVNSEL LNNLGNFINR ALSFVANSFG GVVPEMNLTN
460 470 480 490 500
DDAEVLSEIH NECMQWDKQF DGVHLKDAVK TILNVSRLGN QYMQAQTPWV
510 520 530 540 550
LMKKDEEGKK RAGTIIGVAA NIAYHVSVLL YPIMPTISAT IREQCGLPAL
560 570 580 590 600
PLFTPFPICY LKAGHKIGQP SPLFQKLDPA QIAEFKAKFG GSQDAQSSAP
610 620 630 640 650
KTAEKPKQQK KQAPTKDKKG DKKMASTAAF VELEQGAKVI SQLIAQNLKK
660 670 680 690 700
FDQAKALFTR NQLQRLDGEN KQLTIDVKTL QHQLIELETA AGIKQVPKPV
710 720 730 740 750
VSCTPTPTST PASGIITEAP KKEAPSTPAP SEPKKAKEQK KGKGGAAAAP
760 770 780 790 800
VDDTIDVGRL DMRVGRIIKC EKHPDADALY VEQIDVGESA PRTVVSGLVR
810 820 830 840 850
HVPLDQMQNR LVVVLCNLKP AKMRGVESRA MVMCASSPDK VEIMEVPADS
860 870 880 890 900
KPGTPVVCPP YTHRPDEQLN PKKKIWETVA EDLKVSAEGF AEWKGQPLLI
910
GSESKMTAPT LRGVHVK
Length:917
Mass (Da):101,714
Last modified:November 1, 1996 - v1
Checksum:i3B42AABA314FBDF0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YT55D3YT55_CAEEL
Methionine--tRNA ligase, cytoplasmi...
mars-1 CELE_F58B3.5, F58B3.5
676Annotation score:
D3YT56D3YT56_CAEEL
Methionine--tRNA ligase, cytoplasmi...
mars-1 CELE_F58B3.5, F58B3.5
294Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73427 Genomic DNA Translation: CAA97803.1
PIRiT22898
RefSeqiNP_001255570.1, NM_001268641.1
UniGeneiCel.16977
Cel.40250

Genome annotation databases

EnsemblMetazoaiF58B3.5a; F58B3.5a; WBGene00003415
GeneIDi178089
KEGGicel:CELE_F58B3.5
UCSCiF58B3.5 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73427 Genomic DNA Translation: CAA97803.1
PIRiT22898
RefSeqiNP_001255570.1, NM_001268641.1
UniGeneiCel.16977
Cel.40250

3D structure databases

ProteinModelPortaliQ20970
SMRiQ20970
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F58B3.5a

PTM databases

iPTMnetiQ20970

Proteomic databases

EPDiQ20970
PaxDbiQ20970
PeptideAtlasiQ20970
PRIDEiQ20970

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF58B3.5a; F58B3.5a; WBGene00003415
GeneIDi178089
KEGGicel:CELE_F58B3.5
UCSCiF58B3.5 c. elegans

Organism-specific databases

CTDi178089
WormBaseiF58B3.5a ; CE06007 ; WBGene00003415 ; mars-1

Phylogenomic databases

eggNOGiKOG1247 Eukaryota
KOG2241 Eukaryota
COG0073 LUCA
COG0143 LUCA
GeneTreeiENSGT00550000075017
HOGENOMiHOG000200402
InParanoidiQ20970
KOiK01874
OMAiVCKNTPH
OrthoDBiEOG091G020Y
PhylomeDBiQ20970

Miscellaneous databases

PROiPR:Q20970

Gene expression databases

BgeeiWBGene00003415 Expressed in 5 organ(s), highest expression level in adult organism

Family and domain databases

CDDicd00814 MetRS_core, 1 hit
Gene3Di2.20.28.20, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00098 Met_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR023458 Met-tRNA_ligase_1
IPR014758 Met-tRNA_synth
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR033911 MetRS_core
IPR029038 MetRS_Zn
IPR012340 NA-bd_OB-fold
IPR014729 Rossmann-like_a/b/a_fold
IPR002547 tRNA-bd_dom
IPR009080 tRNAsynth_Ia_anticodon-bd
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PF01588 tRNA_bind, 1 hit
PRINTSiPR01041 TRNASYNTHMET
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50249 SSF50249, 1 hit
SSF57770 SSF57770, 1 hit
TIGRFAMsiTIGR00398 metG, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit
PS50886 TRBD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYMC_CAEEL
AccessioniPrimary (citable) accession number: Q20970
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  3. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
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