UniProtKB - Q20958 (NAS29_CAEEL)
Protein
Zinc metalloproteinase nas-29
Gene
nas-29
Organism
Caenorhabditis elegans
Status
Functioni
Metalloprotease.By similarity
Cofactori
Zn2+PROSITE-ProRule annotationNote: Binds 1 zinc ion per subunit.PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 230 | Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation | 1 | |
Active sitei | 231 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 234 | Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 240 | Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- metalloendopeptidase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- molting cycle, collagen and cuticulin-based cuticle Source: InterPro
Keywordsi
Molecular function | Hydrolase, Metalloprotease, Protease |
Ligand | Metal-binding, Zinc |
Protein family/group databases
MEROPSi | M12.A29 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc metalloproteinase nas-29 (EC:3.4.24.-By similarity)Alternative name(s): Nematode astacin 29 |
Gene namesi | Name:nas-29 ORF Names:F58A6.4 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | F58A6.4 ; CE42691 ; WBGene00003547 ; nas-29 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
PropeptideiPRO_0000442676 | 23 – 134 | By similarityAdd BLAST | 112 | |
ChainiPRO_0000028933 | 135 – 532 | Zinc metalloproteinase nas-29Add BLAST | 398 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 27 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 70 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 106 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 179 ↔ 334 | PROSITE-ProRule annotation | ||
Disulfide bondi | 201 ↔ 222 | PROSITE-ProRule annotation | ||
Disulfide bondi | 338 ↔ 358 | PROSITE-ProRule annotation | ||
Disulfide bondi | 360 ↔ 369 | PROSITE-ProRule annotation | ||
Disulfide bondi | 380 ↔ 408 | PROSITE-ProRule annotation | ||
Disulfide bondi | 435 ↔ 456 | PROSITE-ProRule annotation | ||
Glycosylationi | 503 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, ZymogenProteomic databases
PaxDbi | Q20958 |
Expressioni
Gene expression databases
Bgeei | WBGene00003547, Expressed in multi-cellular organism and 3 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 135 – 335 | Peptidase M12APROSITE-ProRule annotationAdd BLAST | 201 | |
Domaini | 330 – 370 | EGF-likeAdd BLAST | 41 | |
Domaini | 380 – 494 | CUBPROSITE-ProRule annotationAdd BLAST | 115 |
Keywords - Domaini
EGF-like domain, SignalPhylogenomic databases
eggNOGi | KOG3714, Eukaryota |
GeneTreei | ENSGT00940000169152 |
HOGENOMi | CLU_017286_1_5_1 |
InParanoidi | Q20958 |
OMAi | NYPATIW |
OrthoDBi | 681837at2759 |
PhylomeDBi | Q20958 |
Family and domain databases
CDDi | cd00041, CUB, 1 hit cd04280, ZnMc_astacin_like, 1 hit |
Gene3Di | 2.60.120.290, 1 hit |
InterProi | View protein in InterPro IPR034035, Astacin-like_dom IPR000859, CUB_dom IPR000742, EGF-like_dom IPR017050, Metallopeptidase_nem IPR001506, Peptidase_M12A IPR006026, Peptidase_Metallo IPR035914, Sperma_CUB_dom_sf |
Pfami | View protein in Pfam PF01400, Astacin, 1 hit PF00431, CUB, 1 hit |
PIRSFi | PIRSF036365, Astacin_nematoda, 1 hit |
PRINTSi | PR00480, ASTACIN |
SMARTi | View protein in SMART SM00042, CUB, 1 hit SM00235, ZnMc, 1 hit |
SUPFAMi | SSF49854, SSF49854, 1 hit |
PROSITEi | View protein in PROSITE PS51864, ASTACIN, 1 hit PS01180, CUB, 1 hit PS00022, EGF_1, 1 hit PS01186, EGF_2, 1 hit PS00142, ZINC_PROTEASE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q20958-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MISKNTSFCG FLILVLATCM SAQFVSNESI KLHDILKPSA THRLFDTLQY
60 70 80 90 100
SVEEQYSDSH LSFDVSTIYN YSEKPISIGK LNKKYRDILF EGDMAISYKQ
110 120 130 140 150
LSMIVNGSTE YRKAIKSRRR GNKINGESTD RTKRQAYLDN NYPATIWKNG
160 170 180 190 200
VAFMFHESLT PIAKTAILKA VHFWYRETCI EFHPRTFQKE YLLFIGNDDG
210 220 230 240 250
CWSTVGRDAS QGKQVVSIGN GCEHFGVTSH ELAHALGIFH EQSRFDRDES
260 270 280 290 300
VVFNPRVVER DLLFNFAKIS PRQMSTYGLP YDIGSVMHYT PTEFSNIPSI
310 320 330 340 350
PTLAAIDTNL QQTMGQLEGP SFVDVHIMNQ HYQCQEKCPT QAPCQNGGFT
360 370 380 390 400
NSRNCKVCKC PTGFGGAYCQ LIASSFSPFC GGYLNAEETT RRFDITIRQS
410 420 430 440 450
TTTRSKTCVY HIKAPEGKRI IIDILKIDSK CIEGCWQDGL ELKMKKDFRP
460 470 480 490 500
VGYRFCCPES SRRKVISEGN MVPFMVFSKE HDFSVSFEYS FVSTSAGFDD
510 520 530
EKNDSDVIVD NLDGVFVSDT SLLQRIGFRR QL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FO080690 Genomic DNA Translation: CCD65842.1 AJ561218 mRNA Translation: CAD99218.1 |
PIRi | T16493 |
RefSeqi | NP_494953.3, NM_062552.4 |
Genome annotation databases
EnsemblMetazoai | F58A6.4.1; F58A6.4.1; WBGene00003547 |
GeneIDi | 186488 |
KEGGi | cel:CELE_F58A6.4 |
UCSCi | F58A6.4, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FO080690 Genomic DNA Translation: CCD65842.1 AJ561218 mRNA Translation: CAD99218.1 |
PIRi | T16493 |
RefSeqi | NP_494953.3, NM_062552.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
MEROPSi | M12.A29 |
Proteomic databases
PaxDbi | Q20958 |
Genome annotation databases
EnsemblMetazoai | F58A6.4.1; F58A6.4.1; WBGene00003547 |
GeneIDi | 186488 |
KEGGi | cel:CELE_F58A6.4 |
UCSCi | F58A6.4, c. elegans |
Organism-specific databases
CTDi | 186488 |
WormBasei | F58A6.4 ; CE42691 ; WBGene00003547 ; nas-29 |
Phylogenomic databases
eggNOGi | KOG3714, Eukaryota |
GeneTreei | ENSGT00940000169152 |
HOGENOMi | CLU_017286_1_5_1 |
InParanoidi | Q20958 |
OMAi | NYPATIW |
OrthoDBi | 681837at2759 |
PhylomeDBi | Q20958 |
Miscellaneous databases
PROi | PR:Q20958 |
Gene expression databases
Bgeei | WBGene00003547, Expressed in multi-cellular organism and 3 other tissues |
Family and domain databases
CDDi | cd00041, CUB, 1 hit cd04280, ZnMc_astacin_like, 1 hit |
Gene3Di | 2.60.120.290, 1 hit |
InterProi | View protein in InterPro IPR034035, Astacin-like_dom IPR000859, CUB_dom IPR000742, EGF-like_dom IPR017050, Metallopeptidase_nem IPR001506, Peptidase_M12A IPR006026, Peptidase_Metallo IPR035914, Sperma_CUB_dom_sf |
Pfami | View protein in Pfam PF01400, Astacin, 1 hit PF00431, CUB, 1 hit |
PIRSFi | PIRSF036365, Astacin_nematoda, 1 hit |
PRINTSi | PR00480, ASTACIN |
SMARTi | View protein in SMART SM00042, CUB, 1 hit SM00235, ZnMc, 1 hit |
SUPFAMi | SSF49854, SSF49854, 1 hit |
PROSITEi | View protein in PROSITE PS51864, ASTACIN, 1 hit PS01180, CUB, 1 hit PS00022, EGF_1, 1 hit PS01186, EGF_2, 1 hit PS00142, ZINC_PROTEASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NAS29_CAEEL | |
Accessioni | Q20958Primary (citable) accession number: Q20958 Secondary accession number(s): Q7Z0M3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 4, 2005 |
Last sequence update: | December 16, 2008 | |
Last modified: | April 7, 2021 | |
This is version 134 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase