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Entry version 166 (16 Oct 2019)
Sequence version 2 (01 Oct 2001)
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Protein
Submitted name:

Uncharacterized protein

Gene

mrp-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi648 – 655ATPPROSITE-ProRule annotation8
Nucleotide bindingi1320 – 1327ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-382556 ABC-family proteins mediated transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mrp-2Imported
ORF Names:CELE_F57C12.4Imported, F57C12.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
F57C12.4 ; CE26370 ; WBGene00003408 ; mrp-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei42 – 60HelicalSequence analysisAdd BLAST19
Transmembranei72 – 95HelicalSequence analysisAdd BLAST24
Transmembranei107 – 129HelicalSequence analysisAdd BLAST23
Transmembranei141 – 164HelicalSequence analysisAdd BLAST24
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Transmembranei296 – 313HelicalSequence analysisAdd BLAST18
Transmembranei333 – 354HelicalSequence analysisAdd BLAST22
Transmembranei414 – 432HelicalSequence analysisAdd BLAST19
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Transmembranei515 – 543HelicalSequence analysisAdd BLAST29
Transmembranei555 – 577HelicalSequence analysisAdd BLAST23
Transmembranei1009 – 1035HelicalSequence analysisAdd BLAST27
Transmembranei1087 – 1104HelicalSequence analysisAdd BLAST18
Transmembranei1110 – 1127HelicalSequence analysisAdd BLAST18
Transmembranei1192 – 1214HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q20943

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q20943

PeptideAtlas

More...
PeptideAtlasi
Q20943

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003408 Expressed in 4 organ(s), highest expression level in material anatomical entity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.F57C12.4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q20943

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini299 – 582ABC transmembrane type-1InterPro annotationAdd BLAST284
Domaini614 – 839ABC transporterInterPro annotationAdd BLAST226
Domaini968 – 1251ABC transmembrane type-1InterPro annotationAdd BLAST284
Domaini1288 – 1520ABC transporterInterPro annotationAdd BLAST233

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q20943

KEGG Orthology (KO)

More...
KOi
K05665

Identification of Orthologs from Complete Genome Data

More...
OMAi
PWIMNAS

Database of Orthologous Groups

More...
OrthoDBi
138195at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q20943

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00957 MRP_assoc_pro, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q20943-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFPLVRELVC GDKTELLEPG WKNRSSIPHV TKCGQHTDFS TIPTLFLVVF
60 70 80 90 100
SFIVIYQLLH TRTAQLRCFS PISFRIILGC LLVVDLIATV IYDLYLYVSQ
110 120 130 140 150
SPNFEVVHFY GDLVQFGGIC LALILTVACK NKGIITSGVI TLYWLLVVVC
160 170 180 190 200
GIPEFRFYLS GFIYNEYALE GIRATLYIIA FTFSALELFL CCFADVPSDM
210 220 230 240 250
YKSESSCPEY TASFINRLTF QWFTGLAYLG NKKSLENEDL WDLNEIDKAE
260 270 280 290 300
NLIPSFMQNL KPRIDEYHQN IKKDPSAALP KNHPSFVIPI FKTYKYTLLA
310 320 330 340 350
GFFYKLCFDM LQFLAPQLLK QLIGFIEDKN QPVWIGCSIV GIMFFSSFLQ
360 370 380 390 400
SMFLHQYYHS MFRLGMHVRS VLTSAVYSKA LNLSNEARKG KTIGAIVNLM
410 420 430 440 450
SVDIQKIQDM APTIMLFWSA PLQIFLSIYF LWKFLGVAAL AGLVVLILAL
460 470 480 490 500
PVNGLIAIQM RKCQTEQMKL KDERIKMMSE ILNGMKVLKL YSWERSMENM
510 520 530 540 550
VLKIRERELH ILKKLSYFMA AIVFSWICAP FLASVISFVV YVYLDPENNV
560 570 580 590 600
LTPEITFVAL SLFDILRMPL AMVAMVYGEA VQCSVSNTRL KEFFAAEEMS
610 620 630 640 650
PQTSISHGET DSAIEVENGL FSWSSDEDPT LREISFKIQK GQLVAIVGKV
660 670 680 690 700
GSGKSSLLHA LLGEMNKLSG SVQINGNIAY VPQQAWIQNM SLRNNILFNK
710 720 730 740 750
PYDLENYEDV VKNCALKEDL ANLPAGDRTE IGEKGINLSG GQKQRVSLAR
760 770 780 790 800
AVYQNPDIIL LDDPLSAVDS HVGKHIFENV ISSSTGCLAS KTRVLVTHGL
810 820 830 840 850
TYLKHCDQLI VLKEGTISEL GTYQELLNNS GAFAEFLEEF LIEESKTRGR
860 870 880 890 900
VASIGDGSGE VDEILRDLGQ VKPGILKRLE SHLSQESDKE DTSARAIEYS
910 920 930 940 950
RDSSRRSVLL HSPRSQHEEN EALLGAISED VPAQENTQLI EKETVETGKV
960 970 980 990 1000
KFEVYIAYFQ AISIPITLLF FFLYVGSSGL GILSNFYLAK LSDHAKSGNR
1010 1020 1030 1040 1050
TSSDAKMELG IYAVLGMGQS FVVLIASIIL TIGVLRASRI LHAGLLGNIM
1060 1070 1080 1090 1100
RSPMAFFDVT PIGRILNRIG KDIEAIDRTL PDVIRHMSMT IFNVVATLVV
1110 1120 1130 1140 1150
IMWATPWAGI AFAILSVIYF IVLRFYISTS RQLKRLESAS RSPIYSHFQE
1160 1170 1180 1190 1200
SIQGASSIRA FGVVDNFIKQ SQQRVDDHLI AYYPSIVANR WLAVRLEMVG
1210 1220 1230 1240 1250
NLIVLSAAGA AVYFRDSPGL SAGLVGLSVS YALNITQTLN WAVRMTSELE
1260 1270 1280 1290 1300
TNIVSVERIK EYTVTPTEGN NSRRLAAKSW PEKGEISIKN FSVRYRPGLD
1310 1320 1330 1340 1350
LVLHGISAHI APSEKVGIVG RTGAGKSSLT LALFRIIEAD GGSIEIDGIN
1360 1370 1380 1390 1400
IANLQLEQLR SCLTIVPQDP VLFSGTMKMN LDPFSAYSDS QVWEALENAH
1410 1420 1430 1440 1450
LKPFVKSLQD GLEHKISEGG ENLSVGQRQL ICLARALLRK TKVLVLDEAA
1460 1470 1480 1490 1500
AAVDVETDSL IQKTIREQFK ECTVLTIAHR LNTVMDSDRL LVLDKGRVAE
1510 1520
FDSPKNLLAN PDGIFYSMAK DANVV
Length:1,525
Mass (Da):170,177
Last modified:October 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA4D4E6466086F3F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CCD69448.1

Protein sequence database of the Protein Information Resource

More...
PIRi
E89447

NCBI Reference Sequences

More...
RefSeqi
NP_508121.1, NM_075720.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F57C12.4.1; F57C12.4.1; WBGene00003408

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
180408

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F57C12.4

UCSC genome browser

More...
UCSCi
F57C12.4 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CCD69448.1
PIRiE89447
RefSeqiNP_508121.1, NM_075720.5

3D structure databases

SMRiQ20943
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.F57C12.4

Proteomic databases

EPDiQ20943
PaxDbiQ20943
PeptideAtlasiQ20943

Genome annotation databases

EnsemblMetazoaiF57C12.4.1; F57C12.4.1; WBGene00003408
GeneIDi180408
KEGGicel:CELE_F57C12.4
UCSCiF57C12.4 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
180408
WormBaseiF57C12.4 ; CE26370 ; WBGene00003408 ; mrp-2

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
InParanoidiQ20943
KOiK05665
OMAiPWIMNAS
OrthoDBi138195at2759
PhylomeDBiQ20943

Enzyme and pathway databases

ReactomeiR-CEL-382556 ABC-family proteins mediated transport

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q20943

Gene expression databases

BgeeiWBGene00003408 Expressed in 4 organ(s), highest expression level in material anatomical entity

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
TIGRFAMsiTIGR00957 MRP_assoc_pro, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ20943_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q20943
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: October 1, 2001
Last modified: October 16, 2019
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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