UniProtKB - Q20924 (SUN1_CAEEL)
Protein
Sun domain-containing protein 1
Gene
sun-1
Organism
Caenorhabditis elegans
Status
Functioni
Involved in centrosome attachment to the nucleus. Required for zyg-12 localization to the nuclear envelope. Together with pot-1, it is required to anchor telomeres to the nuclear envelope in embryos (PubMed:24297748).2 Publications
GO - Molecular functioni
- protein-membrane adaptor activity Source: GO_Central
GO - Biological processi
- centrosome localization Source: WormBase
- embryo development ending in birth or egg hatching Source: WormBase
- nuclear envelope organization Source: GO_Central
- protein localization Source: WormBase
- regulation of centrosome duplication Source: WormBase
Names & Taxonomyi
Protein namesi | Recommended name: Sun domain-containing protein 1 |
Gene namesi | ORF Names:F57B1.2Imported |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | F57B1.2 ; CE11288 ; WBGene00006311 ; sun-1 |
Subcellular locationi
Nucleus
- Nucleus membrane 1 Publication; Single-pass membrane protein 1 Publication
- Nucleus envelope 1 Publication
Nucleus
- meiotic nuclear membrane microtubule tethering complex Source: GO_Central
- nuclear envelope Source: WormBase
- nuclear membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 262 – 282 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, NucleusPathology & Biotechi
Disruption phenotypei
RNAi-mediated knockdown disrupts both the localization of pot-1 and the anchoring of telomeres to the nuclear envelope in early embryos.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000218921 | 1 – 473 | Sun domain-containing protein 1Add BLAST | 473 |
Proteomic databases
EPDi | Q20924 |
PaxDbi | Q20924 |
PeptideAtlasi | Q20924 |
PTM databases
iPTMneti | Q20924 |
Expressioni
Gene expression databases
Bgeei | WBGene00006311, Expressed in germ line (C elegans) and 4 other tissues |
Interactioni
Binary interactionsi
Q20924
With | #Exp. | IntAct |
---|---|---|
ced-4 [P30429] | 3 | EBI-15599048,EBI-494118 |
Protein-protein interaction databases
BioGRIDi | 44820, 10 interactors |
DIPi | DIP-52612N |
IntActi | Q20924, 2 interactors |
STRINGi | 6239.F57B1.2 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 279 – 443 | SUNPROSITE-ProRule annotationAdd BLAST | 165 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 163 – 191 | Sequence analysisAdd BLAST | 29 | |
Coiled coili | 204 – 235 | Sequence analysisAdd BLAST | 32 |
Domaini
The SUN domain may play a role in the nuclear anchoring.By similarity
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2687, Eukaryota |
HOGENOMi | CLU_029733_1_0_1 |
InParanoidi | Q20924 |
OMAi | VPNHAPK |
OrthoDBi | 1090088at2759 |
Family and domain databases
Gene3Di | 2.60.120.260, 1 hit |
InterProi | View protein in InterPro IPR008979, Galactose-bd-like_sf IPR012919, SUN_dom |
Pfami | View protein in Pfam PF07738, Sad1_UNC, 1 hit |
PROSITEi | View protein in PROSITE PS51469, SUN, 1 hit |
i Sequence
Sequence statusi: Complete.
Q20924-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALRHTISPQ FSNRHSPPVT RSVSRTGVHQ PLDTSTPVTR RDSQPGTITG
60 70 80 90 100
TIQRFHESAD DSEIDLNSSK FIYKEHFSYK EITSMKKEMW YDWLEYRIRM
110 120 130 140 150
VRRRFVPTWA QFKRTLMAVV LFAMLYKYAR DCLFDGTHHN SEGSYADKDA
160 170 180 190 200
NWASEKQKFH QTISNLRAEF SAHDKQLDFK TDHLEKLLEN VLEHSKGWKE
210 220 230 240 250
SAIEELKQIK LWQAEISDAL QQMKKEIDDA KSTKIIHSTP EKAPETAPTA
260 270 280 290 300
SLPPSSQLQP MHITRRALLG VNVANSLIGA SIDHSCSSRP VSAKDGFFYD
310 320 330 340 350
FMSYFGTFQE GYALLDRDVL SPGEAWCTYD KRATLTVKLA RFVIPKSVSY
360 370 380 390 400
QHVRWSGIVP NHAPKLYDVV ACTDSCCTKW QPLVANCEYK ERDGSYDEQE
410 420 430 440 450
QFCSVPTIQN HSPINHVQFR FRENHGDMPK TCAYLIRVYG EPVDPPKETQ
460 470
PMTDNGTESK LESAIVNSVS ETA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX284605 Genomic DNA Translation: CAB01511.1 |
PIRi | T22830 |
RefSeqi | NP_506281.1, NM_073880.4 |
Genome annotation databases
EnsemblMetazoai | F57B1.2.1; F57B1.2.1; WBGene00006311 |
GeneIDi | 179802 |
KEGGi | cel:CELE_F57B1.2 |
UCSCi | F57B1.2, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX284605 Genomic DNA Translation: CAB01511.1 |
PIRi | T22830 |
RefSeqi | NP_506281.1, NM_073880.4 |
3D structure databases
SMRi | Q20924 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 44820, 10 interactors |
DIPi | DIP-52612N |
IntActi | Q20924, 2 interactors |
STRINGi | 6239.F57B1.2 |
PTM databases
iPTMneti | Q20924 |
Proteomic databases
EPDi | Q20924 |
PaxDbi | Q20924 |
PeptideAtlasi | Q20924 |
Genome annotation databases
EnsemblMetazoai | F57B1.2.1; F57B1.2.1; WBGene00006311 |
GeneIDi | 179802 |
KEGGi | cel:CELE_F57B1.2 |
UCSCi | F57B1.2, c. elegans |
Organism-specific databases
CTDi | 179802 |
WormBasei | F57B1.2 ; CE11288 ; WBGene00006311 ; sun-1 |
Phylogenomic databases
eggNOGi | KOG2687, Eukaryota |
HOGENOMi | CLU_029733_1_0_1 |
InParanoidi | Q20924 |
OMAi | VPNHAPK |
OrthoDBi | 1090088at2759 |
Miscellaneous databases
PROi | PR:Q20924 |
Gene expression databases
Bgeei | WBGene00006311, Expressed in germ line (C elegans) and 4 other tissues |
Family and domain databases
Gene3Di | 2.60.120.260, 1 hit |
InterProi | View protein in InterPro IPR008979, Galactose-bd-like_sf IPR012919, SUN_dom |
Pfami | View protein in Pfam PF07738, Sad1_UNC, 1 hit |
PROSITEi | View protein in PROSITE PS51469, SUN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SUN1_CAEEL | |
Accessioni | Q20924Primary (citable) accession number: Q20924 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 2, 2004 |
Last sequence update: | November 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase