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Entry version 151 (07 Oct 2020)
Sequence version 4 (16 Dec 2008)
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Protein

Cubilin homolog

Gene

cubn-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid metabolism, Protein transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cubilin homologImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cubn-1Imported
ORF Names:ZC116.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
ZC116.3 ; CE42882 ; WBGene00013855 ; cubn-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000024851623 – 4047Cubilin homologAdd BLAST4025

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi172 ↔ 183By similarity
Disulfide bondi177 ↔ 193By similarity
Disulfide bondi195 ↔ 204By similarity
Disulfide bondi211 ↔ 227By similarity
Glycosylationi215N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi221 ↔ 236By similarity
Glycosylationi224N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi238 ↔ 247By similarity
Disulfide bondi310 ↔ 321By similarity
Disulfide bondi315 ↔ 330By similarity
Disulfide bondi333 ↔ 344By similarity
Disulfide bondi350 ↔ 363By similarity
Disulfide bondi357 ↔ 372By similarity
Disulfide bondi375 ↔ 386By similarity
Disulfide bondi392 ↔ 403By similarity
Disulfide bondi397 ↔ 418By similarity
Disulfide bondi420 ↔ 434By similarity
Disulfide bondi442 ↔ 453By similarity
Disulfide bondi447 ↔ 463By similarity
Disulfide bondi465 ↔ 474By similarity
Disulfide bondi480 ↔ 491By similarity
Disulfide bondi485 ↔ 500By similarity
Disulfide bondi502 ↔ 511By similarity
Disulfide bondi518 ↔ 544By similarity
Glycosylationi528N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi537N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi577 ↔ 601By similarity
Glycosylationi583N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi645 ↔ 667By similarity
Disulfide bondi696 ↔ 719By similarity
Disulfide bondi769 ↔ 801By similarity
Glycosylationi775N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi806N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi811N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi877 ↔ 896By similarity
Glycosylationi942N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1065 ↔ 1091By similarity
Disulfide bondi1120 ↔ 1145By similarity
Glycosylationi1133N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1188 ↔ 1211By similarity
Glycosylationi1229N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1234 ↔ 1262By similarity
Glycosylationi1294N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1304 ↔ 1330By similarity
Glycosylationi1353N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1428 ↔ 1455By similarity
Disulfide bondi1488 ↔ 1522By similarity
Glycosylationi1513N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1560 ↔ 1586By similarity
Glycosylationi1613N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1614 ↔ 1641By similarity
Glycosylationi1631N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1648N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1674N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1691 ↔ 1720By similarity
Glycosylationi1762N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1782N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1866N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1890N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1955 ↔ 1979By similarity
Glycosylationi2005N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi2006 ↔ 2027By similarity
Glycosylationi2016N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2017N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2193N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2207 ↔ 2238By similarity
Disulfide bondi2265 ↔ 2295By similarity
Glycosylationi2301N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2305N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2335 ↔ 2368By similarity
Disulfide bondi2395 ↔ 2424By similarity
Glycosylationi2434N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2467 ↔ 2498By similarity
Disulfide bondi2590 ↔ 2619By similarity
Glycosylationi2599N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2645N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi2646 ↔ 2668By similarity
Glycosylationi2657N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2692N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2721 ↔ 2747By similarity
Disulfide bondi2786 ↔ 2809By similarity
Glycosylationi2811N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2845N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2875N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2988N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2996 ↔ 3025By similarity
Disulfide bondi3052 ↔ 3074By similarity
Disulfide bondi3127 ↔ 3154By similarity
Disulfide bondi3181 ↔ 3217By similarity
Glycosylationi3235N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3255 ↔ 3281By similarity
Disulfide bondi3315 ↔ 3335By similarity
Disulfide bondi3387 ↔ 3418By similarity
Glycosylationi3421N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi3445 ↔ 3468By similarity
Glycosylationi3461N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3515 ↔ 3544By similarity
Glycosylationi3635N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3645 ↔ 3680By similarity
Disulfide bondi3708 ↔ 3742By similarity
Glycosylationi3770N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3786 ↔ 3815By similarity
Glycosylationi3787N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi3812N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3845 ↔ 3863By similarity
Glycosylationi3858N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi3930N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q20911

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q20911

PeptideAtlas

More...
PeptideAtlasi
Q20911

PRoteomics IDEntifications database

More...
PRIDEi
Q20911

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q20911

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00013855, Expressed in multi-cellular organism and 3 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
44749, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.ZC116.3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q20911

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini168 – 205EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini207 – 248EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini306 – 345EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini346 – 387EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini388 – 435EGF-like 5PROSITE-ProRule annotationAdd BLAST48
Domaini438 – 475EGF-like 6PROSITE-ProRule annotationAdd BLAST38
Domaini476 – 512EGF-like 7PROSITE-ProRule annotationAdd BLAST37
Domaini518 – 641CUB 1PROSITE-ProRule annotationAdd BLAST124
Domaini645 – 763CUB 2PROSITE-ProRule annotationAdd BLAST119
Domaini769 – 934CUB 3PROSITE-ProRule annotationAdd BLAST166
Domaini934 – 1061CUB 4PROSITE-ProRule annotationAdd BLAST128
Domaini1065 – 1182CUB 5PROSITE-ProRule annotationAdd BLAST118
Domaini1188 – 1300CUB 6PROSITE-ProRule annotationAdd BLAST113
Domaini1304 – 1427CUB 7PROSITE-ProRule annotationAdd BLAST124
Domaini1428 – 1558CUB 8PROSITE-ProRule annotationAdd BLAST131
Domaini1560 – 1680CUB 9PROSITE-ProRule annotationAdd BLAST121
Domaini1691 – 1841CUB 10PROSITE-ProRule annotationAdd BLAST151
Domaini1955 – 2083CUB 11PROSITE-ProRule annotationAdd BLAST129
Domaini2207 – 2334CUB 12PROSITE-ProRule annotationAdd BLAST128
Domaini2335 – 2463CUB 13PROSITE-ProRule annotationAdd BLAST129
Domaini2467 – 2588CUB 14PROSITE-ProRule annotationAdd BLAST122
Domaini2590 – 2717CUB 15PROSITE-ProRule annotationAdd BLAST128
Domaini2721 – 2859CUB 16PROSITE-ProRule annotationAdd BLAST139
Domaini2996 – 3121CUB 17PROSITE-ProRule annotationAdd BLAST126
Domaini3127 – 3254CUB 18PROSITE-ProRule annotationAdd BLAST128
Domaini3255 – 3385CUB 19PROSITE-ProRule annotationAdd BLAST131
Domaini3387 – 3508CUB 20PROSITE-ProRule annotationAdd BLAST122
Domaini3515 – 3641CUB 21PROSITE-ProRule annotationAdd BLAST127
Domaini3645 – 3783CUB 22PROSITE-ProRule annotationAdd BLAST139
Domaini3786 – 3900CUB 23PROSITE-ProRule annotationAdd BLAST115

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4292, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000172_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q20911

KEGG Orthology (KO)

More...
KOi
K14616

Identification of Orthologs from Complete Genome Data

More...
OMAi
EWDIRAG

Database of Orthologous Groups

More...
OrthoDBi
4105at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q20911

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00041, CUB, 17 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.290, 23 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000859, CUB_dom
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR035914, Sperma_CUB_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431, CUB, 15 hits
PF00008, EGF, 2 hits
PF07645, EGF_CA, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00042, CUB, 23 hits
SM00181, EGF, 8 hits
SM00179, EGF_CA, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854, SSF49854, 23 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS01180, CUB, 20 hits
PS00022, EGF_1, 4 hits
PS01186, EGF_2, 2 hits
PS50026, EGF_3, 7 hits
PS01187, EGF_CA, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q20911-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIPNLQLFLS LILFGLLNHV SSIDYEEIHI EDSYETRSRI LMVDGNVWLH
60 70 80 90 100
AGKDKNITFK TTGNGRIYVD ETDVSKLPDI ASFKQLVGRI ENTSQMFTTL
110 120 130 140 150
KSRQDTQTSA MRVVLNSAKH YLVALRNMTL EVNILKKWKT DKMARDMRRR
160 170 180 190 200
GLLVKMTRQI IGINKLIAIN ACDPNKCSNG GTCIPSFGAK FTCLCPPHFT
210 220 230 240 250
GTTCEADIDE CSVYNGTTAG CQNNGTCINN RGGFECQCQS GYHGSLCQYH
260 270 280 290 300
MSACSKTFEL CGPHGHCIES IVDPTGQSSS DTTTYKCICD WGFKVSSDKN
310 320 330 340 350
NPTCVDVNEC ESNPCHPGVD CINLPGSFVC SGCPKGYKTD GNVCIDVNEC
360 370 380 390 400
EGEIRVCSPL SKCHNTLGSY YCDSCPTGYS GDGGNCVKDD SCVKNKCHKL
410 420 430 440 450
ATCKVTDDGY SAVGDYTCYC PDGYVGDGIG EEGCVKSASN VCQNHNCVNA
460 470 480 490 500
GKCKPTSDTE YKCECEAGFL GKFCEKTSPC QTNPCKNGGT CIAVENSAYC
510 520 530 540 550
DCPEHFFGRA CEEEEEHCGS HFTHSSGNYT FDLQRSNKTE LSICDFVFNI
560 570 580 590 600
PAANSAVVMT FTEFDKFTQE GSGPTDCAKT DANLTLYDGP EDSSSEFATF
610 620 630 640 650
CGDSHSVHAP LSDTPITMTS TGAMLRFRGT QGSFTIKWET VERKCGYRSS
660 670 680 690 700
KPEGIISVPQ NHQDIVCEWF ISAPGGKIIE VTIPPVSMHS KDIEKCDQNS
710 720 730 740 750
LEIYDGYATY DKHRILETCS STLESQVVRT TGPFLTVAFI SNMLQSDAGL
760 770 780 790 800
ETIRGFVLKY KFTTPDRECG AEIDNDSNDF SFSGVIESPN YGSLYPPNMD
810 820 830 840 850
CTWKINGTLS NGSYSGDMVL KLTFDEYDVK SGFSANGPGM HYRSFRRLLP
860 870 880 890 900
RNEVEYGIAP GFSRVFAYRN LFDMGTCTND FLKIHDGDGT LVQETCNPRR
910 920 930 940 950
PPNVLTVNNP AAVLTFHSDS AEQGKGFRIQ YEMLCEKRVN GNGTIQTWNF
960 970 980 990 1000
PNGGAAGTCT YIIEAPKTHV ISVRFLTIGL RVLPMSECFY TPNAVETYEN
1010 1020 1030 1040 1050
YVEFSGGRTD NALFNRRYVC ARYPFVEGAW MSVSAARRLQ IKVGSDGNPM
1060 1070 1080 1090 1100
FKGLSLEYKT SDVGCGGVFS SMTGTISSPN YPEKYQPHMH CVYNLYVSWS
1110 1120 1130 1140 1150
KTVKLTFDVF DLEVTPAKSC EYDRVEIYTS YHNETVHGEL LGKFCGAMIP
1160 1170 1180 1190 1200
PSIYSTTNTM AVVFVSDRSV AGPGWNAKFE AVSRKTTCDF TLTAPSNNLI
1210 1220 1230 1240 1250
FDPQQLKFDK CTYHIAVHEN QRILIKMNNM SLPCDKSSLM FRNGPSETSP
1260 1270 1280 1290 1300
PFSSLPPESE ICTPKVNYMP VIRSFSNRVT IVYKSINSEG SFFNLTYETI
1310 1320 1330 1340 1350
TSGCGGRVDG LTGIVSAPQY PLGDKKNLKC DWTVAVALGN KVRFALTALD
1360 1370 1380 1390 1400
DLNSSDSGGF CPLFAANRID FFDSALQGNQ HLKRYCAKEM ASEPITSDDN
1410 1420 1430 1440 1450
ELIIKYVQSG GFQSKKIFGF SGHFTTLCNG IVHEAISGSI QSPGYPYKVY
1460 1470 1480 1490 1500
SNQFCTWTIK VPKGNRIVAT VHHFSISQKS YFEGGINCIT DMLKVDDTDL
1510 1520 1530 1540 1550
AEAEVTFKKT DYNITNSVNK YCDKAIPRVI RSRHNSMKLT YSSQGDPTNQ
1560 1570 1580 1590 1600
FWLSWNTLGC SRDITAPQQL IITKENIDPE VDEFECQYKI QAPIGKQINL
1610 1620 1630 1640 1650
KIDKMDILPI GTNCTYTKDF SGFAIFMSDS NKSGTPFQTY CSSINQQNIS
1660 1670 1680 1690 1700
SHTNELFLFL SMKKDKLKTN VFFNATVEFV DVPQSSQSDI CGQVINLERG
1710 1720 1730 1740 1750
KKNYITSPGY PSAYLPGIKC NFLINAPPGY HIEYALEKYY SPYYHDDRKT
1760 1770 1780 1790 1800
DKPRFMSPYT ANYTCKWYLA YNVGMLSFYE GNSSSSSPVE RLCDESDTVQ
1810 1820 1830 1840 1850
TFELYASQSL VIFEGASNYM SQKSGEGVRD QIGFVLSMIP KCGGVVYAES
1860 1870 1880 1890 1900
KPQTISLYHE GEGICNVTIK KKDPQDSEIN IRLEEYTKLN SSSTHTIDDR
1910 1920 1930 1940 1950
IDIYVGGVLK YTEMLKATDN TMQEYASDEE MMISVQNANA PHSAIIVVST
1960 1970 1980 1990 2000
DDKSCGGEVR HSQGTIYAPT RRLDKPFDCG WAISNSNGNT VTLSILDHNL
2010 2020 2030 2040 2050
KSTPNCTDSY IEIRANNSSG KLIKRQCDIS SIDSTEYESQ SLYVFLRYRP
2060 2070 2080 2090 2100
SASDGNDDDD DTPDIDQQDS NKRPLFKARY EKVSGGRPKS RYVSSPMIDN
2110 2120 2130 2140 2150
TEMMVWTLDI VDEKAGILVK FIDLYLPSPT SYLRFTESGE NDDVASSDYE
2160 2170 2180 2190 2200
EVTGVMAPAE KFFETNLIRV YGKLEKSDKF SFTWDPVPLN YRNLTLAKDK
2210 2220 2230 2240 2250
PAKVYDCGGD LTPTYEWDYF TNPLPAGQSF GYEENLHCRW IIRRPMFTGI
2260 2270 2280 2290 2300
ELKFDYLELE DVQNCAFDFV SFRLQFDDQP EENDDVDLSS VSKHCALVRS
2310 2320 2330 2340 2350
NNTFNFSVNR ALHIHFVTDR SRHGIGFKLK YRLTCNSFEH IRPGIFFEHT
2360 2370 2380 2390 2400
LTSPNYDGNF HTPSVWKCQY SLIIESNRKV SVEIVDLDIQ ENSPCSYNNA
2410 2420 2430 2440 2450
LILGNRFSEL VETHSQYSKS SKYCGKLEQG ERLNFTSARG RLFIKYNSGP
2460 2470 2480 2490 2500
NSRKGFKMII KEQLTECPSG VLHVDDNSPS RVLNSPEFPQ RIPNSVECEY
2510 2520 2530 2540 2550
VMAAPNGHRL MLTFDSENFD IDGNQKNCDL LDYIEIRDGP TVHSEVIGIY
2560 2570 2580 2590 2600
CGNQAPSTIF STTNFLYMKL HTSEYGKSRR FVATYGIATC GGTVMVRENV
2610 2620 2630 2640 2650
TTHITSPSFP YPFATPVQCQ WNVKSPNTHM IEAKVDHVWL FYNPNCTMEQ
2660 2670 2680 2690 2700
LMIRDGNSTA NPLIGPVCVP RHAPDVFTRS ASNQITVQFT SNSTTTRGGR
2710 2720 2730 2740 2750
QYCSNKKCGF DVAVTMSGEK CGGRITNLIG TLTPPGYPGK LLSHVKCIWD
2760 2770 2780 2790 2800
FKMKPGFIYR FKITFPGANA YHKFDNQVFR IAKQHCFPDV AVVEGFPPYD
2810 2820 2830 2840 2850
GAQYSTYFCK NETQITSITD TIRIVYDDSH TREMISAIGN DQPLNSTFYA
2860 2870 2880 2890 2900
PFTIDYMAIP ANSENQGCTL QINKNLTTEF HLRNKVNGKG VGLDSFCHVS
2910 2920 2930 2940 2950
IEKPANFESV HIEISDYKAD SELQPAGAKC FSWGAHLKIK SDEPVPIETT
2960 2970 2980 2990 3000
VCDGKSMKNK QSEMIYVNPQ IDLFISQLFR DQEGQQFNLT IEFQKCGGVI
3010 3020 3030 3040 3050
SSPNTGDITS PNFGSGLKYL PGSKCRWVLE APEGQIVKVK IVEMQIAYDH
3060 3070 3080 3090 3100
ECENDHLIIG EGRQADVNTI HKYCHKMDGE QEQKLEDRFK IIKSHGRYLT
3110 3120 3130 3140 3150
LIWVTNMKYE EAGWKIQYEF LNENEECGYH TSGMSGTIYT PMFGDKDYEN
3160 3170 3180 3190 3200
DLECVWDIQV PLGYHINLKF KDFDVETAEN CAKDQLLISQ EHSTRANSPN
3210 3220 3230 3240 3250
GDYYFLFQDE EKETPLCGIE HPKDFESESN RVRLNFTTDS QTTARGFRVN
3260 3270 3280 3290 3300
WEAECGAIYR LNHGVITSPY YPNGYPNDIT CTYLIAPPDQ NSVIAIKFAD
3310 3320 3330 3340 3350
FDLATMRTSF GRAPCEDDYL QIIDTGTDRV LHTFCASEPM PKDALVFKGA
3360 3370 3380 3390 3400
IGLKFVSDKS YYWMEEDNKY GRKGSKGFQL AYSINKCGDN IELREGTGFI
3410 3420 3430 3440 3450
TTVTSPAFPL PYTKDLDCVW NITTDPNRQL NIRFEEMKLE AFHDCSADYI
3460 3470 3480 3490 3500
EFFDSSDIMA NKTLGKFCGT MDKIPQYRIV TSGPNLLIHM RTDFNVNSGG
3510 3520 3530 3540 3550
FKLAVISSLG QKEGCGGKLT ATTSWQTLTS PKDEDGNYPP ALLCGWTISG
3560 3570 3580 3590 3600
PVDSQLQIRI DGVDTEQLEY PPGDRPSPEC IDALAIYDGQ EFFSPLLAGD
3610 3620 3630 3640 3650
ICTSGTPLPK ILYTSHRHAF ITFETDRDGT GRGFNISYSI VDSDCGGWLK
3660 3670 3680 3690 3700
ATNEIKTLVY KGITSDDNKE MNKERSHQRC RFMIQGPKTE PVIVNFQQFN
3710 3720 3730 3740 3750
IPSKAGDCSD SFVEIRDVGS LQECKHPACA REPNQRKITK LCGTHVPTSH
3760 3770 3780 3790 3800
VSNTNTIQII VSADIMPNKN QSRPSLKFEY NILDSCNRTI DTNTIKSGRL
3810 3820 3830 3840 3850
TSPNYPQVYS ENSTCVTNLQ SSNQKMLLVF NDFTLEEPNN VNKNCDYDYL
3860 3870 3880 3890 3900
MLKEGDSNGT YYCGSTLPKA LMTSGKDLTA LLKSDHSLNH AGYDASYYTV
3910 3920 3930 3940 3950
VSERDDQIQF ADSYELEGVI SSIGYPNGYN KSYTQIFTLR PPNSHDCSII
3960 3970 3980 3990 4000
FTDVSISMTQ LPEECFQPTE EYLEIEVKFK TQVKKARIRS CTFALKKARE
4010 4020 4030 4040
LILEADNNDR YIKFAFKSDA KSENDGRGFK IRWKCHSIGK TQAVLPS
Length:4,047
Mass (Da):453,276
Last modified:December 16, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF8A620A00A68F649
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX284605, Z74473 Genomic DNA Translation: CAA98557.3

Protein sequence database of the Protein Information Resource

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PIRi
T22812

NCBI Reference Sequences

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RefSeqi
NP_506157.3, NM_073756.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
ZC116.3.1; ZC116.3.1; WBGene00013855

Database of genes from NCBI RefSeq genomes

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GeneIDi
179729

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_ZC116.3

UCSC genome browser

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UCSCi
ZC116.3, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605, Z74473 Genomic DNA Translation: CAA98557.3
PIRiT22812
RefSeqiNP_506157.3, NM_073756.5

3D structure databases

SMRiQ20911
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi44749, 1 interactor
STRINGi6239.ZC116.3

PTM databases

iPTMnetiQ20911

Proteomic databases

EPDiQ20911
PaxDbiQ20911
PeptideAtlasiQ20911
PRIDEiQ20911

Genome annotation databases

EnsemblMetazoaiZC116.3.1; ZC116.3.1; WBGene00013855
GeneIDi179729
KEGGicel:CELE_ZC116.3
UCSCiZC116.3, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
179729
WormBaseiZC116.3 ; CE42882 ; WBGene00013855 ; cubn-1

Phylogenomic databases

eggNOGiKOG4292, Eukaryota
HOGENOMiCLU_000172_1_0_1
InParanoidiQ20911
KOiK14616
OMAiEWDIRAG
OrthoDBi4105at2759
PhylomeDBiQ20911

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q20911

Gene expression databases

BgeeiWBGene00013855, Expressed in multi-cellular organism and 3 other tissues

Family and domain databases

CDDicd00041, CUB, 17 hits
Gene3Di2.60.120.290, 23 hits
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR035914, Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431, CUB, 15 hits
PF00008, EGF, 2 hits
PF07645, EGF_CA, 3 hits
SMARTiView protein in SMART
SM00042, CUB, 23 hits
SM00181, EGF, 8 hits
SM00179, EGF_CA, 6 hits
SUPFAMiSSF49854, SSF49854, 23 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS01180, CUB, 20 hits
PS00022, EGF_1, 4 hits
PS01186, EGF_2, 2 hits
PS50026, EGF_3, 7 hits
PS01187, EGF_CA, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCUBN_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q20911
Secondary accession number(s): Q23242
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: December 16, 2008
Last modified: October 7, 2020
This is version 151 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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