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Protein

Elongation of very long chain fatty acids protein

Gene

elo-7

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotation
Biological processFatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-CEL-2046105 Linoleic acid (LA) metabolism
R-CEL-2046106 alpha-linolenic acid (ALA) metabolism
R-CEL-75876 Synthesis of very long-chain fatty acyl-CoAs

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation of very long chain fatty acids proteinUniRule annotation (EC:2.3.1.199UniRule annotation)
Alternative name(s):
Very-long-chain 3-oxoacyl-CoA synthaseUniRule annotation
Gene namesi
Name:elo-7Imported
ORF Names:CELE_F56H11.3Imported, F56H11.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF56H11.3 ; CE35559 ; WBGene00001245 ; elo-7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei66 – 83HelicalUniRule annotationAdd BLAST18
Transmembranei104 – 122HelicalUniRule annotationAdd BLAST19
Transmembranei147 – 168HelicalUniRule annotationAdd BLAST22
Transmembranei175 – 193HelicalUniRule annotationAdd BLAST19
Transmembranei199 – 218HelicalUniRule annotationAdd BLAST20
Transmembranei230 – 256HelicalUniRule annotationAdd BLAST27
Transmembranei268 – 289HelicalUniRule annotationAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ20904

Expressioni

Gene expression databases

BgeeiWBGene00001245 Expressed in 3 organ(s), highest expression level in multi-cellular organism

Interactioni

Protein-protein interaction databases

STRINGi6239.F56H11.3a

Structurei

3D structure databases

ProteinModelPortaliQ20904
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ELO family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG3071 Eukaryota
ENOG410XRWT LUCA
GeneTreeiENSGT00760000119122
HOGENOMiHOG000038943
InParanoidiQ20904
OMAiLFVHAFM
OrthoDBiEOG091G0EKU
PhylomeDBiQ20904

Family and domain databases

InterProiView protein in InterPro
IPR030457 ELO_CS
IPR002076 ELO_fam
PANTHERiPTHR11157 PTHR11157, 1 hit
PfamiView protein in Pfam
PF01151 ELO, 1 hit
PROSITEiView protein in PROSITE
PS01188 ELO, 1 hit

Sequencei

Sequence statusi: Complete.

Q20904-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYLNYFATEI FHRSAVCETE ACRSSKIMIA DVFKWKFDAN ELWSLLTNQD
60 70 80 90 100
EVFPHIRARR FIQEHFGLFV QMAIAYVILV FSIKRFMRDR EPFQLTTALR
110 120 130 140 150
LWNFFLSVFS IYGSWTMFPF MVQQIRLYGL YGCGCEALSN LPSQAEYWLF
160 170 180 190 200
LTILSKAVEF VDTFFLVLRK KPLIFLHWYH HMATFVFFCS NYPTPSSQSR
210 220 230 240 250
VGVIVNLFVH AFMYPYYFTR SMNIKVPAKI SMAVTVLQLT QFMCFIYGCT
260 270 280 290 300
LMYYSLATNQ YTCDTPMFVL HSTFALSSSY FVLFANFFHK AYLQRGGKRE

HPNQTKKIN
Length:309
Mass (Da):36,521
Last modified:July 5, 2004 - v3
Checksum:iA32262B9A769DDA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAA92960.2
PIRiT22791
RefSeqiNP_001255397.1, NM_001268468.1
UniGeneiCel.12814

Genome annotation databases

EnsemblMetazoaiF56H11.3; F56H11.3; WBGene00001245
GeneIDi186426
KEGGicel:CELE_F56H11.3
UCSCiF56H11.3 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAA92960.2
PIRiT22791
RefSeqiNP_001255397.1, NM_001268468.1
UniGeneiCel.12814

3D structure databases

ProteinModelPortaliQ20904
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F56H11.3a

Proteomic databases

PaxDbiQ20904

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF56H11.3; F56H11.3; WBGene00001245
GeneIDi186426
KEGGicel:CELE_F56H11.3
UCSCiF56H11.3 c. elegans

Organism-specific databases

CTDi186426
WormBaseiF56H11.3 ; CE35559 ; WBGene00001245 ; elo-7

Phylogenomic databases

eggNOGiKOG3071 Eukaryota
ENOG410XRWT LUCA
GeneTreeiENSGT00760000119122
HOGENOMiHOG000038943
InParanoidiQ20904
OMAiLFVHAFM
OrthoDBiEOG091G0EKU
PhylomeDBiQ20904

Enzyme and pathway databases

ReactomeiR-CEL-2046105 Linoleic acid (LA) metabolism
R-CEL-2046106 alpha-linolenic acid (ALA) metabolism
R-CEL-75876 Synthesis of very long-chain fatty acyl-CoAs

Gene expression databases

BgeeiWBGene00001245 Expressed in 3 organ(s), highest expression level in multi-cellular organism

Family and domain databases

InterProiView protein in InterPro
IPR030457 ELO_CS
IPR002076 ELO_fam
PANTHERiPTHR11157 PTHR11157, 1 hit
PfamiView protein in Pfam
PF01151 ELO, 1 hit
PROSITEiView protein in PROSITE
PS01188 ELO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ20904_CAEEL
AccessioniPrimary (citable) accession number: Q20904
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 110 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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