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Entry version 158 (16 Oct 2019)
Sequence version 3 (01 Mar 2003)
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Protein
Submitted name:

PX domain-containing protein

Gene

rskd-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q20821

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
PX domain-containing proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rskd-1Imported
ORF Names:CELE_F55C5.7Imported, F55C5.7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
F55C5.7a ; CE31961 ; WBGene00010096 ; rskd-1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q20821

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q20821

PeptideAtlas

More...
PeptideAtlasi
Q20821

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00010096 Expressed in 5 organ(s), highest expression level in multi-cellular organism

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q20821 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q20821, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.F55C5.7a

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 153PXInterPro annotationAdd BLAST128
Domaini513 – 783Protein kinaseInterPro annotationAdd BLAST271

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni171 – 191DisorderedSequence analysisAdd BLAST21
Regioni502 – 536DisorderedSequence analysisAdd BLAST35
Regioni560 – 593DisorderedSequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi171 – 189PolarSequence analysisAdd BLAST19
Compositional biasi561 – 593PolarSequence analysisAdd BLAST33

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0603 Eukaryota
KOG2101 Eukaryota
ENOG410XNWQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168182

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000022450

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q20821

KEGG Orthology (KO)

More...
KOi
K20839

Identification of Orthologs from Complete Genome Data

More...
OMAi
NRYLNCN

Database of Orthologous Groups

More...
OrthoDBi
255297at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q20821

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR007330 MIT
IPR036181 MIT_dom_sf
IPR001683 Phox
IPR000719 Prot_kinase_dom
IPR036871 PX_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04212 MIT, 1 hit
PF00069 Pkinase, 1 hit
PF00787 PX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00745 MIT, 1 hit
SM00312 PX, 1 hit
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF116846 SSF116846, 1 hit
SSF56112 SSF56112, 2 hits
SSF64268 SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50195 PX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q20821-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSLYPDESY CTSDIGRILY QLKTDWSCSS TVTSISEEKH LTGSHTVYTV
60 70 80 90 100
EIECNPVASH LVANDVSRRT FVLSTRYKEM TKLHAAISKL HKQLYLRGTF
110 120 130 140 150
PVFPPGKLIG SSDPSVIQER RHAIEACLNF VFDSEVLRKS RLLHEFVEKA
160 170 180 190 200
KEKTYTAHEI TGNEVFYDNS SSILDQPNTN SSDSDSPNHA ALLEPTHEQT
210 220 230 240 250
GDDFQFPDVA IASETSNEEQ RTARKSSMKR LFPRLRGSTH HNIEIEETPA
260 270 280 290 300
DYLVTAGQLV ATAQRAEEEH AYELAFQCYK SAASSLIQGV HIESDMTKRN
310 320 330 340 350
AVRRKTAKYL VKAEKLYRTY LSLDGSVFNF EGLLTAAMQD PNILAFQCSN
360 370 380 390 400
KSMKNYRFIG VLPELDAERK VILVEETIGE SNKKYVMKLI EKGVPSSDCS
410 420 430 440 450
IFLPTNIPHM VQLVQFFETE THIILLLEFV EPGQLWSFLR RMFDEAESRH
460 470 480 490 500
VLWLAELKAD VRDGDTTSEV TVQITKNEGN YRGRRLLFTV GVDYERVVEM
510 520 530 540 550
RDESFSSEKP SDESLLCTVG EDPTGRSDAP TGDFTIAGNS REAAESHYFQ
560 570 580 590 600
VEEESPAAVK FDFSSSKSQS PRGNRISSEN QNHSPSSSKV VKLDSADSSN
610 620 630 640 650
SKEMFLKNLW KALQTVQKQL SLRRRVWNYL DLPESLIVHW SAQIVSFFFV
660 670 680 690 700
LHAEHHEFIG DFNADDILID SDGNLLMTYI GRWYETNRRK RLTDGYSAPE
710 720 730 740 750
SSQYGWEPTP ESDIWTLGAL LFEMLCGRSL ANAAPHGVLR NMELPIPEKV
760 770 780 790 800
VVSFVAKDLL NMLLVPTPAL RPSLDEIRAH PFFRHIDWLL YDNPTSPSTP
810 820 830 840
ATVTRIQSPP TPPSSIDIPE VSVDNVIISN LEEPSTSRVS PTSRRILF
Length:848
Mass (Da):95,813
Last modified:March 1, 2003 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iABC82CEB35530F7D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8WHT6A8WHT6_CAEEL
PX domain-containing protein
rskd-1 CELE_F55C5.7, F55C5.7
204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAB01572.2

Protein sequence database of the Protein Information Resource

More...
PIRi
T22717

NCBI Reference Sequences

More...
RefSeqi
NP_506082.2, NM_073681.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F55C5.7a.1; F55C5.7a.1; WBGene00010096

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
179685

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F55C5.7

UCSC genome browser

More...
UCSCi
F55C5.7a c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAB01572.2
PIRiT22717
RefSeqiNP_506082.2, NM_073681.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ20821, 1 interactor
STRINGi6239.F55C5.7a

Proteomic databases

EPDiQ20821
PaxDbiQ20821
PeptideAtlasiQ20821

Genome annotation databases

EnsemblMetazoaiF55C5.7a.1; F55C5.7a.1; WBGene00010096
GeneIDi179685
KEGGicel:CELE_F55C5.7
UCSCiF55C5.7a c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
179685
WormBaseiF55C5.7a ; CE31961 ; WBGene00010096 ; rskd-1

Phylogenomic databases

eggNOGiKOG0603 Eukaryota
KOG2101 Eukaryota
ENOG410XNWQ LUCA
GeneTreeiENSGT00940000168182
HOGENOMiHOG000022450
InParanoidiQ20821
KOiK20839
OMAiNRYLNCN
OrthoDBi255297at2759
PhylomeDBiQ20821

Enzyme and pathway databases

SignaLinkiQ20821

Gene expression databases

BgeeiWBGene00010096 Expressed in 5 organ(s), highest expression level in multi-cellular organism
ExpressionAtlasiQ20821 baseline and differential

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR007330 MIT
IPR036181 MIT_dom_sf
IPR001683 Phox
IPR000719 Prot_kinase_dom
IPR036871 PX_dom_sf
PfamiView protein in Pfam
PF04212 MIT, 1 hit
PF00069 Pkinase, 1 hit
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00745 MIT, 1 hit
SM00312 PX, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF116846 SSF116846, 1 hit
SSF56112 SSF56112, 2 hits
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50195 PX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ20821_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q20821
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: March 1, 2003
Last modified: October 16, 2019
This is version 158 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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