F55A11.4

Functionⁱ

Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane.By similarity

Caution

Could be the product of a pseudogene.Curated

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Calcium bindingⁱ	86 – 97	1PROSITE-ProRule annotationAdd BLAST		12
Calcium bindingⁱ	153 – 164	2PROSITE-ProRule annotationAdd BLAST		12

GO - Molecular functionⁱ

ADP transmembrane transporter activity Source: GO_Central
ATP transmembrane transporter activity Source: GO_Central
calcium ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mitochondrial transport Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport
Ligand	Calcium, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Putative calcium-binding mitochondrial carrier F55A11.4
Gene namesⁱ	ORF Names:F55A11.4
Organismⁱ	Caenorhabditis elegans
Taxonomic identifierⁱ	6239 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis
Proteomesⁱ	UP000001940 Componentⁱ: Chromosome V

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	252 – 269	Helical; Name=1By similarityAdd BLAST	18
Transmembraneⁱ	307 – 326	Helical; Name=2By similarityAdd BLAST	20
Transmembraneⁱ	352 – 365	Helical; Name=3By similarityAdd BLAST	14
Transmembraneⁱ	403 – 422	Helical; Name=4By similarityAdd BLAST	20
Transmembraneⁱ	446 – 463	Helical; Name=5By similarityAdd BLAST	18
Transmembraneⁱ	504 – 523	Helical; Name=6By similarityAdd BLAST	20

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000090604	1 – 588	Putative calcium-binding mitochondrial carrier F55A11.4Add BLAST		588

Proteomic databases

EPDⁱ	Q20799
PaxDbⁱ	Q20799

Expressionⁱ

Gene expression databases

Bgeeⁱ	WBGene00010077 Expressed in 5 organ(s), highest expression level in material anatomical entity

Bgeeⁱ

WBGene00010077 Expressed in 5 organ(s), highest expression level in material anatomical entity

Interactionⁱ

Subunit structureⁱ

Homodimer (via N-terminus).By similarity

Protein-protein interaction databases

STRINGⁱ	6239.F55A11.4a

STRINGⁱ

6239.F55A11.4a

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q20799
SMRⁱ	Q20799
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	73 – 108	EF-hand 1PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	109 – 139	EF-hand 2PROSITE-ProRule annotationAdd BLAST	31
Domainⁱ	140 – 175	EF-hand 3PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	176 – 211	EF-hand 4PROSITE-ProRule annotationAdd BLAST	36
Repeatⁱ	246 – 332	Solcar 1PROSITE-ProRule annotationAdd BLAST	87
Repeatⁱ	342 – 428	Solcar 2PROSITE-ProRule annotationAdd BLAST	87
Repeatⁱ	440 – 529	Solcar 3PROSITE-ProRule annotationAdd BLAST	90

Sequence similaritiesⁱ

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0036 Eukaryota ENOG410XQ4P LUCA
HOGENOMⁱ	HOG000165728
InParanoidⁱ	Q20799

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00051 EFh, 1 hit
Gene3Dⁱ	1.50.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR002167 Graves_DC IPR002067 Mit_carrier IPR018108 Mitochondrial_sb/sol_carrier IPR023395 Mt_carrier_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13499 EF-hand_7, 1 hit PF00153 Mito_carr, 3 hits
PRINTSⁱ	PR00928 GRAVESDC PR00926 MITOCARRIER
SMARTⁱ	View protein in SMART SM00054 EFh, 3 hits
SUPFAMⁱ	SSF103506 SSF103506, 1 hit SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 2 hits PS50222 EF_HAND_2, 3 hits PS50920 SOLCAR, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q20799-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MINKNEQTES TSGAAEQKED DEEQYVQLSS LGEYKDEVTP LLSPKHVPLV 
        60         70         80         90        100
LGKVTKEAAI ATHSALHGGM SEEKERQIRD IYDRLDIDND GTIDIRDLTL 
       110        120        130        140        150
ALKHETPHIP ANLAPVIMSK MSPDDEGRVD FYSFSSYVLE NEQKLAEMFA 
       160        170        180        190        200
DMDRNHDGLV DVVEMKNYCK DIGVPLDDHK AQHIVNKMDQ TGSASVDLKE 
       210        220        230        240        250
FQEFMMLYPS SDLKDIVDFW RHNLIIDIGE DSQIPEDFSQ QEMQEGIWWR 
       260        270        280        290        300
HLVAGGAAGA VSRTCTAPFD RIKVYLQVNS SKTNRLGVMS CLKLLHAEGG 
       310        320        330        340        350
IKSFWRGNGI NVIKIAPESA IKFMCYDQLK RLIQKKKGNE EISTFERLCA 
       360        370        380        390        400
GSAAGAISQS TIYPMEVMKT RLALRKTGQL DRGIIHFAHK MYTKEGIRCF 
       410        420        430        440        450
YKGYLPNLIG IIPYAGIDLA IYETLKRTYV RYYETNSSEP GVLALLACGT 
       460        470        480        490        500
CSSTCGQLSS YPFALVRTRL QALSITRYSP QPDTMFGQFK YILQNEGVTG 
       510        520        530        540        550
FYRGITPNFL KVIPAVSISY VVYEKVRTGL GVPVCSRGGL EDIHQFLPCS 
       560        570        580 
IHSIIQFFFF PRTFLLTISG RSLRVKPVWR SHFSKFNK

Length:588

Mass (Da):66,337

Last modified:November 1, 1996 - v1

Checksum:ⁱ68DDF60923D8697D

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	C8JQR9	C8JQR9_CAEEL		Uncharacterized protein Uncharacterized protein	CELE_F55A11.4, F55A11.4	535	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z72511 Genomic DNA No translation available.
PIRⁱ	T22688

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q20799	Uncharacterized protein		CAEEL		535	UniRef90_Q20799

Protein	Similar proteins		Species	Score	Length	Source
Q20799	Probable calcium-binding mitochondrial carrier CBG00135		CAEBR		532	UniRef50_Q20799
Probable calcium-binding mitochondrial carrier F17E5.2		CAEEL		531
Uncharacterized protein		STRVS		538
Uncharacterized protein		STREA		538
Calcium-binding carrier		ASCSU		595
+34

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z72511 Genomic DNA No translation available.
PIRⁱ	T22688

3D structure databases

ProteinModelPortalⁱ	Q20799
SMRⁱ	Q20799
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	6239.F55A11.4a

STRINGⁱ

6239.F55A11.4a

Proteomic databases

EPDⁱ	Q20799
PaxDbⁱ	Q20799

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

eggNOGⁱ	KOG0036 Eukaryota ENOG410XQ4P LUCA
HOGENOMⁱ	HOG000165728
InParanoidⁱ	Q20799

Gene expression databases

Bgeeⁱ	WBGene00010077 Expressed in 5 organ(s), highest expression level in material anatomical entity

Bgeeⁱ

WBGene00010077 Expressed in 5 organ(s), highest expression level in material anatomical entity

Family and domain databases

CDDⁱ	cd00051 EFh, 1 hit
Gene3Dⁱ	1.50.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR002167 Graves_DC IPR002067 Mit_carrier IPR018108 Mitochondrial_sb/sol_carrier IPR023395 Mt_carrier_dom_sf
Pfamⁱ	View protein in Pfam PF13499 EF-hand_7, 1 hit PF00153 Mito_carr, 3 hits
PRINTSⁱ	PR00928 GRAVESDC PR00926 MITOCARRIER
SMARTⁱ	View protein in SMART SM00054 EFh, 3 hits
SUPFAMⁱ	SSF103506 SSF103506, 1 hit SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 2 hits PS50222 EF_HAND_2, 3 hits PS50920 SOLCAR, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CMC2_CAEEL
Accessionⁱ	Q20799Primary (citable) accession number: Q20799
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	November 1, 1996
	Last modified:	October 10, 2018
	This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Caenorhabditis annotation project

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q20799 (CMC2_CAEEL)

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Putative calcium-binding mitochondrial carrier F55A11.4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ