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Protein

Putative calcium-binding mitochondrial carrier F55A11.4

Gene

F55A11.4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane.By similarity

Caution

Could be the product of a pseudogene.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi86 – 971PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi153 – 1642PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative calcium-binding mitochondrial carrier F55A11.4
Gene namesi
ORF Names:F55A11.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei252 – 269Helical; Name=1By similarityAdd BLAST18
Transmembranei307 – 326Helical; Name=2By similarityAdd BLAST20
Transmembranei352 – 365Helical; Name=3By similarityAdd BLAST14
Transmembranei403 – 422Helical; Name=4By similarityAdd BLAST20
Transmembranei446 – 463Helical; Name=5By similarityAdd BLAST18
Transmembranei504 – 523Helical; Name=6By similarityAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906041 – 588Putative calcium-binding mitochondrial carrier F55A11.4Add BLAST588

Proteomic databases

EPDiQ20799
PaxDbiQ20799

Expressioni

Gene expression databases

BgeeiWBGene00010077 Expressed in 5 organ(s), highest expression level in material anatomical entity

Interactioni

Subunit structurei

Homodimer (via N-terminus).By similarity

Protein-protein interaction databases

STRINGi6239.F55A11.4a

Structurei

3D structure databases

ProteinModelPortaliQ20799
SMRiQ20799
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 108EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini109 – 139EF-hand 2PROSITE-ProRule annotationAdd BLAST31
Domaini140 – 175EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini176 – 211EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Repeati246 – 332Solcar 1PROSITE-ProRule annotationAdd BLAST87
Repeati342 – 428Solcar 2PROSITE-ProRule annotationAdd BLAST87
Repeati440 – 529Solcar 3PROSITE-ProRule annotationAdd BLAST90

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0036 Eukaryota
ENOG410XQ4P LUCA
HOGENOMiHOG000165728
InParanoidiQ20799

Family and domain databases

CDDicd00051 EFh, 1 hit
Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR002167 Graves_DC
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF00153 Mito_carr, 3 hits
PRINTSiPR00928 GRAVESDC
PR00926 MITOCARRIER
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
SSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits
PS50920 SOLCAR, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q20799-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MINKNEQTES TSGAAEQKED DEEQYVQLSS LGEYKDEVTP LLSPKHVPLV
60 70 80 90 100
LGKVTKEAAI ATHSALHGGM SEEKERQIRD IYDRLDIDND GTIDIRDLTL
110 120 130 140 150
ALKHETPHIP ANLAPVIMSK MSPDDEGRVD FYSFSSYVLE NEQKLAEMFA
160 170 180 190 200
DMDRNHDGLV DVVEMKNYCK DIGVPLDDHK AQHIVNKMDQ TGSASVDLKE
210 220 230 240 250
FQEFMMLYPS SDLKDIVDFW RHNLIIDIGE DSQIPEDFSQ QEMQEGIWWR
260 270 280 290 300
HLVAGGAAGA VSRTCTAPFD RIKVYLQVNS SKTNRLGVMS CLKLLHAEGG
310 320 330 340 350
IKSFWRGNGI NVIKIAPESA IKFMCYDQLK RLIQKKKGNE EISTFERLCA
360 370 380 390 400
GSAAGAISQS TIYPMEVMKT RLALRKTGQL DRGIIHFAHK MYTKEGIRCF
410 420 430 440 450
YKGYLPNLIG IIPYAGIDLA IYETLKRTYV RYYETNSSEP GVLALLACGT
460 470 480 490 500
CSSTCGQLSS YPFALVRTRL QALSITRYSP QPDTMFGQFK YILQNEGVTG
510 520 530 540 550
FYRGITPNFL KVIPAVSISY VVYEKVRTGL GVPVCSRGGL EDIHQFLPCS
560 570 580
IHSIIQFFFF PRTFLLTISG RSLRVKPVWR SHFSKFNK
Length:588
Mass (Da):66,337
Last modified:November 1, 1996 - v1
Checksum:i68DDF60923D8697D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C8JQR9C8JQR9_CAEEL
Uncharacterized protein
CELE_F55A11.4, F55A11.4
535Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72511 Genomic DNA No translation available.
PIRiT22688

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72511 Genomic DNA No translation available.
PIRiT22688

3D structure databases

ProteinModelPortaliQ20799
SMRiQ20799
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F55A11.4a

Proteomic databases

EPDiQ20799
PaxDbiQ20799

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0036 Eukaryota
ENOG410XQ4P LUCA
HOGENOMiHOG000165728
InParanoidiQ20799

Gene expression databases

BgeeiWBGene00010077 Expressed in 5 organ(s), highest expression level in material anatomical entity

Family and domain databases

CDDicd00051 EFh, 1 hit
Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR002167 Graves_DC
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF00153 Mito_carr, 3 hits
PRINTSiPR00928 GRAVESDC
PR00926 MITOCARRIER
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
SSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits
PS50920 SOLCAR, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCMC2_CAEEL
AccessioniPrimary (citable) accession number: Q20799
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1996
Last modified: October 10, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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Main funding by: National Institutes of Health

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