UniProtKB - Q20799 (CMC2_CAEEL)
Protein
Putative calcium-binding mitochondrial carrier F55A11.4
Gene
F55A11.4
Organism
Caenorhabditis elegans
Status
Functioni
Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane.By similarity
Caution
Could be the product of a pseudogene.Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 86 – 97 | 1PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 153 – 164 | 2PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- ATP transmembrane transporter activity Source: GO_Central
- calcium ion binding Source: InterPro
Keywordsi
Biological process | Transport |
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Putative calcium-binding mitochondrial carrier F55A11.4 |
Gene namesi | ORF Names:F55A11.4 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 252 – 269 | Helical; Name=1By similarityAdd BLAST | 18 | |
Transmembranei | 307 – 326 | Helical; Name=2By similarityAdd BLAST | 20 | |
Transmembranei | 352 – 365 | Helical; Name=3By similarityAdd BLAST | 14 | |
Transmembranei | 403 – 422 | Helical; Name=4By similarityAdd BLAST | 20 | |
Transmembranei | 446 – 463 | Helical; Name=5By similarityAdd BLAST | 18 | |
Transmembranei | 504 – 523 | Helical; Name=6By similarityAdd BLAST | 20 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090604 | 1 – 588 | Putative calcium-binding mitochondrial carrier F55A11.4Add BLAST | 588 |
Proteomic databases
EPDi | Q20799 |
PaxDbi | Q20799 |
Expressioni
Gene expression databases
Bgeei | WBGene00010077, Expressed in material anatomical entity and 5 other tissues |
Interactioni
Subunit structurei
Homodimer (via N-terminus).
By similarityProtein-protein interaction databases
STRINGi | 6239.F55A11.4a |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 73 – 108 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 109 – 139 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 31 | |
Domaini | 140 – 175 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 176 – 211 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 36 | |
Repeati | 246 – 332 | Solcar 1PROSITE-ProRule annotationAdd BLAST | 87 | |
Repeati | 342 – 428 | Solcar 2PROSITE-ProRule annotationAdd BLAST | 87 | |
Repeati | 440 – 529 | Solcar 3PROSITE-ProRule annotationAdd BLAST | 90 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0036, Eukaryota |
HOGENOMi | CLU_015166_2_0_1 |
InParanoidi | Q20799 |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR002167, Graves_DC IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit PF00153, Mito_carr, 3 hits |
PRINTSi | PR00928, GRAVESDC PR00926, MITOCARRIER |
SMARTi | View protein in SMART SM00054, EFh, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 3 hits PS50920, SOLCAR, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q20799-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MINKNEQTES TSGAAEQKED DEEQYVQLSS LGEYKDEVTP LLSPKHVPLV
60 70 80 90 100
LGKVTKEAAI ATHSALHGGM SEEKERQIRD IYDRLDIDND GTIDIRDLTL
110 120 130 140 150
ALKHETPHIP ANLAPVIMSK MSPDDEGRVD FYSFSSYVLE NEQKLAEMFA
160 170 180 190 200
DMDRNHDGLV DVVEMKNYCK DIGVPLDDHK AQHIVNKMDQ TGSASVDLKE
210 220 230 240 250
FQEFMMLYPS SDLKDIVDFW RHNLIIDIGE DSQIPEDFSQ QEMQEGIWWR
260 270 280 290 300
HLVAGGAAGA VSRTCTAPFD RIKVYLQVNS SKTNRLGVMS CLKLLHAEGG
310 320 330 340 350
IKSFWRGNGI NVIKIAPESA IKFMCYDQLK RLIQKKKGNE EISTFERLCA
360 370 380 390 400
GSAAGAISQS TIYPMEVMKT RLALRKTGQL DRGIIHFAHK MYTKEGIRCF
410 420 430 440 450
YKGYLPNLIG IIPYAGIDLA IYETLKRTYV RYYETNSSEP GVLALLACGT
460 470 480 490 500
CSSTCGQLSS YPFALVRTRL QALSITRYSP QPDTMFGQFK YILQNEGVTG
510 520 530 540 550
FYRGITPNFL KVIPAVSISY VVYEKVRTGL GVPVCSRGGL EDIHQFLPCS
560 570 580
IHSIIQFFFF PRTFLLTISG RSLRVKPVWR SHFSKFNK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC8JQR9 | C8JQR9_CAEEL | Uncharacterized protein | CELE_F55A11.4, F55A11.4 | 535 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z72511 Genomic DNA No translation available. |
PIRi | T22688 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z72511 Genomic DNA No translation available. |
PIRi | T22688 |
3D structure databases
SMRi | Q20799 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 6239.F55A11.4a |
Proteomic databases
EPDi | Q20799 |
PaxDbi | Q20799 |
Phylogenomic databases
eggNOGi | KOG0036, Eukaryota |
HOGENOMi | CLU_015166_2_0_1 |
InParanoidi | Q20799 |
Gene expression databases
Bgeei | WBGene00010077, Expressed in material anatomical entity and 5 other tissues |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR002167, Graves_DC IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit PF00153, Mito_carr, 3 hits |
PRINTSi | PR00928, GRAVESDC PR00926, MITOCARRIER |
SMARTi | View protein in SMART SM00054, EFh, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 3 hits PS50920, SOLCAR, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CMC2_CAEEL | |
Accessioni | Q20799Primary (citable) accession number: Q20799 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | November 1, 1996 | |
Last modified: | August 12, 2020 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families