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UniProtKB - Q20797 (STX5_CAEEL)
Protein
Putative syntaxin-5
Gene
syx-5
Organism
Caenorhabditis elegans
Status
Functioni
Potentially involved in docking of synaptic vesicles at presynaptic active zones.
By similarityGO - Molecular functioni
- SNAP receptor activity Source: GO_Central
- SNARE binding Source: GO_Central
GO - Biological processi
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: GO_Central
- intracellular protein transport Source: GO_Central
- synaptic vesicle docking Source: UniProtKB
- vesicle docking Source: GO_Central
- vesicle fusion Source: GO_Central
Keywordsi
Biological process | Neurotransmitter transport, Transport |
Enzyme and pathway databases
Reactomei | R-CEL-204005, COPII-mediated vesicle transport R-CEL-5694530, Cargo concentration in the ER R-CEL-6807878, COPI-mediated anterograde transport R-CEL-6811438, Intra-Golgi traffic R-CEL-9013106, RHOC GTPase cycle R-CEL-9609523, Insertion of tail-anchored proteins into the endoplasmic reticulum membrane |
Names & Taxonomyi
Protein namesi | Recommended name: Putative syntaxin-5 |
Gene namesi | Name:syx-5 Synonyms:syn-3 ORF Names:F55A11.2 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | F55A11.2 ; CE05944 ; WBGene00006373 ; syx-5 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type IV membrane protein Curated
Golgi apparatus
- Golgi membrane Source: GO_Central
Other locations
- endomembrane system Source: GO_Central
- integral component of membrane Source: GO_Central
- presynapse Source: GOC
- SNARE complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 391 | CytoplasmicSequence analysisAdd BLAST | 391 | |
Transmembranei | 392 – 412 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 413 | ExtracellularSequence analysis | 1 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000210241 | 1 – 413 | Putative syntaxin-5Add BLAST | 413 |
Proteomic databases
EPDi | Q20797 |
PaxDbi | Q20797 |
PeptideAtlasi | Q20797 |
PRIDEi | Q20797 |
PTM databases
iPTMneti | Q20797 |
Expressioni
Gene expression databases
Bgeei | WBGene00006373, Expressed in adult organism and 5 other tissues |
Interactioni
GO - Molecular functioni
- SNARE binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 44636, 5 interactors |
IntActi | Q20797, 4 interactors |
STRINGi | 6239.F55A11.2 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 321 – 383 | t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST | 63 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 257 – 290 | DisorderedSequence analysisAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 270 – 290 | Polar residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the syntaxin family.Curated
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0812, Eukaryota |
GeneTreei | ENSGT01000000214440 |
HOGENOMi | CLU_044998_1_1_1 |
InParanoidi | Q20797 |
OMAi | NEFRACV |
OrthoDBi | 1297427at2759 |
PhylomeDBi | Q20797 |
Family and domain databases
InterProi | View protein in InterPro IPR010989, SNARE IPR045242, Syntaxin IPR021538, Syntaxin-5_N IPR006012, Syntaxin/epimorphin_CS IPR000727, T_SNARE_dom |
PANTHERi | PTHR19957, PTHR19957, 1 hit |
Pfami | View protein in Pfam PF05739, SNARE, 1 hit PF11416, Syntaxin-5_N, 1 hit |
SMARTi | View protein in SMART SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q20797-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDFHNIRSR RRIPEASSYS TVDFDYDPDQ KNHTSAVAPT SFAYSSLTTV
60 70 80 90 100
FNASASQLWN SAQEALVSSY DTAEGTESID ADRSKVVETL ESLSIFGNPL
110 120 130 140 150
DHIIITMPSR DRTSEFRATA KSYEMKAAAN GIRPQPKHEM LSESVQFNQL
160 170 180 190 200
AKRIGKELSQ TCAKMEKLAE YAKKKSCYEE RSQIDHLSSI VKSDITGLNK
210 220 230 240 250
QIGQLQEFSK RRAGNMKNQN SGHIQLVVVG LQSKLANVGK DYQSVLEIST
260 270 280 290 300
ETMKAEKNRR DKFSSGAAVP MGLPSSSSGA NVRSKLLQDD EQHGSSSIAL
310 320 330 340 350
DMGALSNMQS QQTMQQRDSS LEYAQARSNT MATIEGSISE LGQIFSQLAS
360 370 380 390 400
LVSEQGEMIT RIDSNVEDTA LNIDMAHSEL VRYLQNISKN RWLMIQVFGV
410
LMVFFVVFVL FLT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z72511 Genomic DNA Translation: CAA96656.1 |
PIRi | T22686 |
RefSeqi | NP_505968.1, NM_073567.6 |
Genome annotation databases
EnsemblMetazoai | F55A11.2.1; F55A11.2.1; WBGene00006373 |
GeneIDi | 179611 |
KEGGi | cel:CELE_F55A11.2 |
UCSCi | F55A11.2, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z72511 Genomic DNA Translation: CAA96656.1 |
PIRi | T22686 |
RefSeqi | NP_505968.1, NM_073567.6 |
3D structure databases
SMRi | Q20797 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 44636, 5 interactors |
IntActi | Q20797, 4 interactors |
STRINGi | 6239.F55A11.2 |
PTM databases
iPTMneti | Q20797 |
Proteomic databases
EPDi | Q20797 |
PaxDbi | Q20797 |
PeptideAtlasi | Q20797 |
PRIDEi | Q20797 |
Genome annotation databases
EnsemblMetazoai | F55A11.2.1; F55A11.2.1; WBGene00006373 |
GeneIDi | 179611 |
KEGGi | cel:CELE_F55A11.2 |
UCSCi | F55A11.2, c. elegans |
Organism-specific databases
CTDi | 179611 |
WormBasei | F55A11.2 ; CE05944 ; WBGene00006373 ; syx-5 |
Phylogenomic databases
eggNOGi | KOG0812, Eukaryota |
GeneTreei | ENSGT01000000214440 |
HOGENOMi | CLU_044998_1_1_1 |
InParanoidi | Q20797 |
OMAi | NEFRACV |
OrthoDBi | 1297427at2759 |
PhylomeDBi | Q20797 |
Enzyme and pathway databases
Reactomei | R-CEL-204005, COPII-mediated vesicle transport R-CEL-5694530, Cargo concentration in the ER R-CEL-6807878, COPI-mediated anterograde transport R-CEL-6811438, Intra-Golgi traffic R-CEL-9013106, RHOC GTPase cycle R-CEL-9609523, Insertion of tail-anchored proteins into the endoplasmic reticulum membrane |
Miscellaneous databases
PROi | PR:Q20797 |
Gene expression databases
Bgeei | WBGene00006373, Expressed in adult organism and 5 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR010989, SNARE IPR045242, Syntaxin IPR021538, Syntaxin-5_N IPR006012, Syntaxin/epimorphin_CS IPR000727, T_SNARE_dom |
PANTHERi | PTHR19957, PTHR19957, 1 hit |
Pfami | View protein in Pfam PF05739, SNARE, 1 hit PF11416, Syntaxin-5_N, 1 hit |
SMARTi | View protein in SMART SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | STX5_CAEEL | |
Accessioni | Q20797Primary (citable) accession number: Q20797 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families