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Protein

Probable glutaryl-CoA dehydrogenase, mitochondrial

Gene

F54D5.7

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Glutaryl-CoA + electron-transfer flavoprotein = crotonyl-CoA + CO2 + reduced electron-transfer flavoprotein.

Cofactori

FADBy similarity

Pathwayi: lysine degradation

This protein is involved in the pathway lysine degradation, which is part of Amino-acid metabolism.
View all proteins of this organism that are known to be involved in the pathway lysine degradation and in Amino-acid metabolism.

Pathwayi: tryptophan metabolism

This protein is involved in the pathway tryptophan metabolism, which is part of Amino-acid metabolism.
View all proteins of this organism that are known to be involved in the pathway tryptophan metabolism and in Amino-acid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei158FADBy similarity1
Binding sitei158Substrate; via carbonyl oxygenBy similarity1
Binding sitei268SubstrateBy similarity1
Active sitei388Proton acceptorBy similarity1
Binding sitei390FADBy similarity1
Binding sitei408FAD; via carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi149 – 152FADBy similarity4
Nucleotide bindingi184 – 186FADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-CEL-71064 Lysine catabolism
UniPathwayiUPA00224
UPA00225

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutaryl-CoA dehydrogenase, mitochondrial (EC:1.3.8.6)
Short name:
GCD
Gene namesi
ORF Names:F54D5.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF54D5.7 ; CE03411 ; WBGene00010052

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000000530? – 409Probable glutaryl-CoA dehydrogenase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ20772
PaxDbiQ20772
PeptideAtlasiQ20772
PRIDEiQ20772

Expressioni

Gene expression databases

BgeeiWBGene00010052

Interactioni

Protein-protein interaction databases

BioGridi40074, 5 interactors
DIPiDIP-25054N
IntActiQ20772, 6 interactors
STRINGi6239.F54D5.7.2

Structurei

3D structure databases

ProteinModelPortaliQ20772
SMRiQ20772
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 111Substrate bindingBy similarity2
Regioni261 – 265Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0138 Eukaryota
COG1960 LUCA
GeneTreeiENSGT00760000119007
HOGENOMiHOG000131662
InParanoidiQ20772
KOiK00252
OMAiTQTYEGQ
OrthoDBiEOG091G07GZ
PhylomeDBiQ20772

Family and domain databases

Gene3Di1.10.540.10, 1 hit
InterProiView protein in InterPro
IPR006089 Acyl-CoA_DH_CS
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR036250 AcylCo_DH-like_C
IPR009075 AcylCo_DH/oxidase_C
IPR013786 AcylCoA_DH/ox_N
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF00441 Acyl-CoA_dh_1, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF02771 Acyl-CoA_dh_N, 1 hit
SUPFAMiSSF47203 SSF47203, 1 hit
SSF56645 SSF56645, 1 hit
PROSITEiView protein in PROSITE
PS00073 ACYL_COA_DH_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q20772-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTRGFTSIG KIASRGLSST FYQDAFQLSD QLTEDERSLM LSAREYCQER
60 70 80 90 100
LLPRVTEAYR TEKFDPSLIP EMGSMGLLGA PYQGYGCAGT STVGYGLIAR
110 120 130 140 150
EVERVDSGYR STMSVQTSLV IGPIYNYGSE DQKQKYIPDL ASGKKIGCFG
160 170 180 190 200
LTEPNHGSNP GGMETKATWD ETTKTYKLNG SKTWISNSPV SDVMVVWARS
210 220 230 240 250
ARHNNKIKGF ILERGMKGLT TPKIEGKLSL RASITGQIAM DDVPVPEENL
260 270 280 290 300
LPNAEGLQGP FGCLNNARLG IAWGALGAAE ECFHLARQYT LDRQQFGRPL
310 320 330 340 350
AQNQLMQLKM ADMLTEISLG LQGCLRVSRL KDEGKVQSEQ ISIIKRNSCG
360 370 380 390 400
KALEVARKAR DMLGGNGIVD EYHIMRHMVN LETVNTYEGT HDVHALILGR

AITGLNGFC
Length:409
Mass (Da):44,964
Last modified:November 1, 1996 - v1
Checksum:i4D06241FB6768069
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z66513 Genomic DNA Translation: CAA91333.1
PIRiT22647
RefSeqiNP_496469.1, NM_064068.5
UniGeneiCel.30446

Genome annotation databases

EnsemblMetazoaiF54D5.7.1; F54D5.7.1; WBGene00010052
F54D5.7.2; F54D5.7.2; WBGene00010052
GeneIDi174768
KEGGicel:CELE_F54D5.7
UCSCiF54D5.7.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiGCDH_CAEEL
AccessioniPrimary (citable) accession number: Q20772
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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