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Entry version 153 (07 Apr 2021)
Sequence version 2 (01 Oct 2001)
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Protein

Nuclear migration and anchoring protein unc-84

Gene

unc-84

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in nuclear migration and anchoring in hypodermal precursor cells (PubMed:10375507, PubMed:11748140, PubMed:12169658, PubMed:11907270, PubMed:16481402, PubMed:20921138, PubMed:21411627, PubMed:23150597, PubMed:25023515, PubMed:25057012). Most likely recruits anc-1 to the nuclear envelope where anc-1 functions to tether the nucleus to the actin cytoskeleton (PubMed:12169658). Component of the unc-83-unc-84 LINC (LInker of Nucleoskeleton and Cytoskeleton) complex where it recruits and interacts with unc-83 to form a bridge connecting the nuclear envelope to the cytoskeleton which allows for nuclear transport along microtubules (PubMed:11748140, PubMed:16481402). Its role in nuclear migration may be in association with lamin, lmn-1 (PubMed:25057012). Regulates nuclear migrations in one-cell embryos, controlling the posterior migration of the male pronucleus following fertilization (PubMed:21798253). Not required for centrosome attachment to the nucleus (PubMed:10375507, PubMed:11907270). Plays a role in the maintenance of the nuclear envelope architecture in body wall muscle cells (PubMed:25023515). May be involved in DNA damage repair through an association with zyg-12 (PubMed:27956467). Potentially has roles in homologous recombination, double strand break repair and meiotic recombination (PubMed:27956467). Specifically, may in part inhibit non-homologous end joining repair, most likely through recruiting fan-1 to the nucleoplasm, to facilitate the repair of DNA cross-links (PubMed:27956467).12 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei91May be involved in the interaction with lmn-11 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • lamin binding Source: WormBase
  • protein-membrane adaptor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear migration and anchoring protein unc-84
Alternative name(s):
Uncoordinated protein 84
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:unc-84Imported
ORF Names:F54B11.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
F54B11.3a ; CE28236 ; WBGene00006816 ; unc-84
F54B11.3b ; CE27761 ; WBGene00006816 ; unc-84

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 509Nuclear1 PublicationAdd BLAST509
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei510 – 530Helical1 PublicationAdd BLAST21
Topological domaini531 – 1111Perinuclear space1 PublicationAdd BLAST581

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1 – 208Missing in n322; defects in nuclear migration in hyp7 hypodermal precursor cells. No nuclear envelope localization defects in hyp7 precursor cells. Does not affect the localization of unc-83 to the nuclear membrane in embryos. 4 PublicationsAdd BLAST208
Mutagenesisi40 – 161Missing in e1174; defects in nuclear migration in distal tip cells and hyp7 hypodermal precursor cells. 2 PublicationsAdd BLAST122
Mutagenesisi91P → S in e1411; defective nuclear migration in hyp7 hypodermal precursor cells. Does not affect unc-83 localization to the nuclear membrane in embryos. May reduce interaction with lmn-1. Reduces number of viable progeny following incubation with the DNA cross-linking agent cisplatin. 1 Publication4 Publications1
Mutagenesisi118 – 244Missing : Abolishes localization to the nuclear envelope of hyp7 precursor cells. 1 PublicationAdd BLAST127
Mutagenesisi932D → N in n323; defective nuclear migration and anchoring in hyp7 hypodermal precursor cells. No defects in localization to the nuclear envelope, however unc-83 localization to the nuclear envelope is abolished. 3 Publications1
Mutagenesisi984R → K in n371; defects in nuclear migration and anchoring in hyp7 hypodermal precursor cells. No defects in localization to the nuclear envelope, however unc-83 localization to the nuclear envelope is abolished. 3 Publications1
Mutagenesisi988S → F in sa61; defects in nuclear migration and anchoring in hyp7 hypodermal precursor cells. No defects in localization to the nuclear envelope, however unc-83 localization to the nuclear envelope is abolished. 3 Publications1
Mutagenesisi994C → Y in e1410; defects in nuclear migration and anchoring in hyp7 hypodermal precursor cells. Defective male pronuclear migration in one-cell embryos following fertilization. Reduced number of viable progeny following incubation with the DNA cross-linking agent cisplatin. 3 Publications1
Mutagenesisi1002G → D in n321 and n399; defects in nuclear migration and anchoring in hyp7 hypodermal precursor cells. No defects in localization to the nuclear envelope, however unc-83 localization to the nuclear envelope is abolished. Reduced number of viable progeny following incubation with the DNA cross-linking agent cisplatin. 5 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002189101 – 1111Nuclear migration and anchoring protein unc-84Add BLAST1111

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q20745

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q20745

PeptideAtlas

More...
PeptideAtlasi
Q20745

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q20745

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all somatic cells (PubMed:11907270, PubMed:27956467). Not expressed in germ cells in the mitotic and transition zones of the gonad (PubMed:11907270). One study shows expression at the beginning of the late pachytene stage in the proximal gonad, but there is no expression in the male germline, suggesting expression is specific to oogenesis in hermaphrodites (PubMed:27956467).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in all cells of embryos from the 26-cell stage (PubMed:10375507, PubMed:11907270). Then, it is ubiquitously expressed throughout the development (PubMed:10375507, PubMed:11907270). Not expressed between fertilization and the 26-cell stage (PubMed:11907270).2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by DNA-damage.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006816, Expressed in multi-cellular organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the unc-83-unc-84 LINC complex which contains at least unc-83 and unc-84 (PubMed:11748140, PubMed:16481402). Within the unc-83-unc-84 LINC complex interacts (via C-terminus) with unc-83; the interaction is probably required to recruit unc-83 to the nuclear membrane (PubMed:11748140, PubMed:16481402). Most likely interacts with anc-1; the interaction is probably required to recruit anc-1 to the nuclear envelope (PubMed:12169658).

Interacts (via C-terminus) with zyg-12 (via C-terminus); the interaction is direct (PubMed:27956467). May interact with lmn-1; this interaction may be required to complete the connection between the nuclear lamina and the cytoskeleton (PubMed:25057012).

5 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
46381, 11 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1385, unc-83-unc-84 LINC complex

Protein interaction database and analysis system

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IntActi
Q20745, 5 interactors

STRING: functional protein association networks

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STRINGi
6239.F54B11.3a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q20745

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini945 – 1109SUNPROSITE-ProRule annotationAdd BLAST165

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni118 – 244Required for nuclear envelope localization1 PublicationAdd BLAST127
Regioni503 – 507Required for nuclear envelope localization1 Publication5
Regioni912 – 1111Interaction with zyg-121 PublicationAdd BLAST200

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SUN domain probably plays a role in the nuclear anchoring and/or migration. Required for the localization of unc-83 and anc-1 at the nuclear membrane.2 Publications

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2687, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000167324

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_009427_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q20745

Identification of Orthologs from Complete Genome Data

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OMAi
SPNIFAK

Database of Orthologous Groups

More...
OrthoDBi
266644at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.120.260, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR008979, Galactose-bd-like_sf
IPR012919, SUN_dom

Pfam protein domain database

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Pfami
View protein in Pfam
PF07738, Sad1_UNC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51469, SUN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform aImported (identifier: Q20745-1) [UniParc]FASTAAdd to basket
Also known as: L1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPATEADNN FDTHEWKSEF ASTRSGRNSP NIFAKVRRKL LLTPPVRNAR
60 70 80 90 100
SPRLTEEELD ALTGDLPYAT NYTYAYSKIY DPSLPDHWEV PNLGGTTSGS
110 120 130 140 150
LSEQEHWSAA SLSRQLLYIL RFPVYLVLHV ITYILEAFYH VIKITSFTIW
160 170 180 190 200
DYLLYLVKLA KTRYYAYQDH RRRTALIRNR QEPFSTKAAR SIRRFFEILV
210 220 230 240 250
YVVLTPYRML TRSNNGVEQY QYRSIKDQLE NERASRMTTR SQTLERSRKF
260 270 280 290 300
DGLSKSPARR AAPAFVKTST ITRITAKVFS SSPFGEGTSE NITPTVVTTR
310 320 330 340 350
TVKQRSVTPR FRQTRATREA ITRALDTPEL EIDTPLSTYG LRSRGLSHLN
360 370 380 390 400
TPEPTFDIGH AAATSTPLFP QETYNYQYEE ATGNKIKTAF TWLGYLILFP
410 420 430 440 450
FFAARHVWYT FYDYGKSAYM KLTNYQQAPM ETIHVRDINE PAPSSSDVHD
460 470 480 490 500
AVGVSWRIRI ADFLSSFVAT IVEAHQVVFA MFKGGIVETV SYFGGLFAGL
510 520 530 540 550
TDKKSSKFSW CQILGLLLAL LFAIFLLGFL TSDNTAIRVK EITKDKNASK
560 570 580 590 600
KSEGSLPAVP IWISAANHVK HYTWMVKEFV VDIAFDTYNY GKSTIGRLGT
610 620 630 640 650
TPRYAWDLIA SGCGAVGNGL KSVLSSSFRF IDFCAGKLFY YGSDGFLSAN
660 670 680 690 700
KSIGTFFNGC YETLYNGCTA IVGHTKSFIY NASNAVYNFF STIFAGLLNF
710 720 730 740 750
STSSQNSILS LLKSFGTGIT NIFYNFIYAP IAGVFNFAGD NYMYFFNEVA
760 770 780 790 800
AVFGKVYNSV VSVLKTVINW ILFLIAYPFS LCTRAWIRIS QYAPEDVVQV
810 820 830 840 850
IPIPQAITPT PDVERIVEEP LRKVTDVEDE ELVIIPAPAP KPIPVPAPTP
860 870 880 890 900
APVIIHQTNV VETVDKDAII KEVTEKLRAE LSAQFQQELS AKFEQNYNTI
910 920 930 940 950
IEQLKMENTN IQYDKNHLEA IIRQMIYEYD TDKTGKVDYA LESSGGAVVS
960 970 980 990 1000
TRCSETYKSY TRLEKFWDIP IYYFHYSPRV VIQRNSKSLF PGECWCFKES
1010 1020 1030 1040 1050
RGYIAVELSH FIDVSSISYE HIGSEVAPEG NRSSAPKGVL VWAYKQIDDL
1060 1070 1080 1090 1100
NSRVLIGDYT YDLDGPPLQF FLAKHKPDFP VKFVELEVTS NYGAPFTCLY
1110
RLRVHGKVVQ V
Length:1,111
Mass (Da):125,861
Last modified:October 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A07438E2BDC8BA6
GO
Isoform bImported (identifier: Q20745-2) [UniParc]FASTAAdd to basket
Also known as: S1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     877-879: LRA → VTN
     880-1111: Missing.

Show »
Length:879
Mass (Da):99,017
Checksum:i6EC7CDD6EA96C546
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_007081877 – 879LRA → VTN in isoform b. 1 Publication3
Alternative sequenceiVSP_007082880 – 1111Missing in isoform b. 1 PublicationAdd BLAST232

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF200706 mRNA Translation: AAF15883.1
AF200707 mRNA Translation: AAF15884.1
Z70208 Genomic DNA Translation: CAA94142.2
Z70208 Genomic DNA Translation: CAC42306.1

Protein sequence database of the Protein Information Resource

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PIRi
T22608

NCBI Reference Sequences

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RefSeqi
NP_001024707.1, NM_001029536.2 [Q20745-1]
NP_001024708.1, NM_001029537.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F54B11.3a.1; F54B11.3a.1; WBGene00006816 [Q20745-1]
F54B11.3b.1; F54B11.3b.1; WBGene00006816 [Q20745-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
181480

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_F54B11.3

UCSC genome browser

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UCSCi
F54B11.3b.2, c. elegans [Q20745-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200706 mRNA Translation: AAF15883.1
AF200707 mRNA Translation: AAF15884.1
Z70208 Genomic DNA Translation: CAA94142.2
Z70208 Genomic DNA Translation: CAC42306.1
PIRiT22608
RefSeqiNP_001024707.1, NM_001029536.2 [Q20745-1]
NP_001024708.1, NM_001029537.3

3D structure databases

SMRiQ20745
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi46381, 11 interactors
ComplexPortaliCPX-1385, unc-83-unc-84 LINC complex
IntActiQ20745, 5 interactors
STRINGi6239.F54B11.3a

PTM databases

iPTMnetiQ20745

Proteomic databases

EPDiQ20745
PaxDbiQ20745
PeptideAtlasiQ20745

Genome annotation databases

EnsemblMetazoaiF54B11.3a.1; F54B11.3a.1; WBGene00006816 [Q20745-1]
F54B11.3b.1; F54B11.3b.1; WBGene00006816 [Q20745-2]
GeneIDi181480
KEGGicel:CELE_F54B11.3
UCSCiF54B11.3b.2, c. elegans [Q20745-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
181480
WormBaseiF54B11.3a ; CE28236 ; WBGene00006816 ; unc-84
F54B11.3b ; CE27761 ; WBGene00006816 ; unc-84

Phylogenomic databases

eggNOGiKOG2687, Eukaryota
GeneTreeiENSGT00940000167324
HOGENOMiCLU_009427_0_0_1
InParanoidiQ20745
OMAiSPNIFAK
OrthoDBi266644at2759

Miscellaneous databases

Protein Ontology

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PROi
PR:Q20745

Gene expression databases

BgeeiWBGene00006816, Expressed in multi-cellular organism and 5 other tissues

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR008979, Galactose-bd-like_sf
IPR012919, SUN_dom
PfamiView protein in Pfam
PF07738, Sad1_UNC, 1 hit
PROSITEiView protein in PROSITE
PS51469, SUN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUNC84_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q20745
Secondary accession number(s): Q9U475, Q9U476
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: October 1, 2001
Last modified: April 7, 2021
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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