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Protein

Tubulin-specific chaperone B

Gene

tbcb-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer.By similarity

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin-specific chaperone B
Alternative name(s):
Tubulin-folding cofactor B
Short name:
CoB
Gene namesi
Name:tbcb-1Imported
ORF Names:F53F4.3Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF53F4.3 ; CE10958 ; WBGene00009987 ; tbcb-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835461 – 229Tubulin-specific chaperone BAdd BLAST229

Proteomic databases

EPDiQ20728
PaxDbiQ20728
PeptideAtlasiQ20728
PRIDEiQ20728

Expressioni

Gene expression databases

BgeeiWBGene00009987 Expressed in 5 organ(s), highest expression level in material anatomical entity

Interactioni

Subunit structurei

Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state (By similarity).By similarity

Protein-protein interaction databases

STRINGi6239.F53F4.3

Structurei

Secondary structure

1229
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ20728
SMRiQ20728
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ20728

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini170 – 212CAP-GlyPROSITE-ProRule annotationAdd BLAST43

Sequence similaritiesi

Belongs to the TBCB family.Curated

Phylogenomic databases

eggNOGiKOG3206 Eukaryota
ENOG410YKGB LUCA
GeneTreeiENSGT00760000119173
HOGENOMiHOG000209180
InParanoidiQ20728
KOiK17262
OMAiYNEEEMQ
OrthoDBiEOG091G0M22
PhylomeDBiQ20728

Family and domain databases

Gene3Di2.30.30.190, 1 hit
InterProiView protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF01302 CAP_GLY, 1 hit
PF14560 Ubiquitin_2, 1 hit
SMARTiView protein in SMART
SM01052 CAP_GLY, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
SSF74924 SSF74924, 1 hit
PROSITEiView protein in PROSITE
PS00845 CAP_GLY_1, 1 hit
PS50245 CAP_GLY_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q20728-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEVYDLEIT TNATDFPMEK KYPAGMSLND LKKKLELVVG TTVDSMRIQL
60 70 80 90 100
FDGDDQLKGE LTDGAKSLKD LGVRDGYRIH AVDVTGGNED FKDESMVEKY
110 120 130 140 150
EMSDDTYGKR TDSVRAWKKK MQEEQGSAAP MENESDKLNE EAAKNIMVGN
160 170 180 190 200
RCEVTVGAQM ARRGEVAYVG ATKFKEGVWV GVKYDEPVGK NDGSVAGVRY
210 220
FDCDPKYGGF VRPVDVKVGD FPELSIDEI
Length:229
Mass (Da):25,441
Last modified:November 1, 1996 - v1
Checksum:iC465365DAE378A0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z77663 Genomic DNA Translation: CAB01212.1
PIRiT22581
RefSeqiNP_506367.1, NM_073966.1
UniGeneiCel.3444

Genome annotation databases

EnsemblMetazoaiF53F4.3; F53F4.3; WBGene00009987
GeneIDi186176
KEGGicel:CELE_F53F4.3
UCSCiF53F4.3 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z77663 Genomic DNA Translation: CAB01212.1
PIRiT22581
RefSeqiNP_506367.1, NM_073966.1
UniGeneiCel.3444

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LPLX-ray1.77A135-229[»]
1T0YNMR-A1-120[»]
1TOVX-ray1.77A132-229[»]
ProteinModelPortaliQ20728
SMRiQ20728
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F53F4.3

Proteomic databases

EPDiQ20728
PaxDbiQ20728
PeptideAtlasiQ20728
PRIDEiQ20728

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF53F4.3; F53F4.3; WBGene00009987
GeneIDi186176
KEGGicel:CELE_F53F4.3
UCSCiF53F4.3 c. elegans

Organism-specific databases

CTDi186176
WormBaseiF53F4.3 ; CE10958 ; WBGene00009987 ; tbcb-1

Phylogenomic databases

eggNOGiKOG3206 Eukaryota
ENOG410YKGB LUCA
GeneTreeiENSGT00760000119173
HOGENOMiHOG000209180
InParanoidiQ20728
KOiK17262
OMAiYNEEEMQ
OrthoDBiEOG091G0M22
PhylomeDBiQ20728

Miscellaneous databases

EvolutionaryTraceiQ20728
PROiPR:Q20728

Gene expression databases

BgeeiWBGene00009987 Expressed in 5 organ(s), highest expression level in material anatomical entity

Family and domain databases

Gene3Di2.30.30.190, 1 hit
InterProiView protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF01302 CAP_GLY, 1 hit
PF14560 Ubiquitin_2, 1 hit
SMARTiView protein in SMART
SM01052 CAP_GLY, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
SSF74924 SSF74924, 1 hit
PROSITEiView protein in PROSITE
PS00845 CAP_GLY_1, 1 hit
PS50245 CAP_GLY_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTBCB_CAEEL
AccessioniPrimary (citable) accession number: Q20728
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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