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Protein

Tubulin-specific chaperone B

Gene

tbcb-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer.By similarity

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin-specific chaperone B
Alternative name(s):
Tubulin-folding cofactor B
Short name:
CoB
Gene namesi
Name:tbcb-1Imported
ORF Names:F53F4.3Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF53F4.3 ; CE10958 ; WBGene00009987 ; tbcb-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835461 – 229Tubulin-specific chaperone BAdd BLAST229

Proteomic databases

EPDiQ20728
PaxDbiQ20728
PeptideAtlasiQ20728
PRIDEiQ20728

Expressioni

Gene expression databases

BgeeiWBGene00009987

Interactioni

Subunit structurei

Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state (By similarity).By similarity

Protein-protein interaction databases

STRINGi6239.F53F4.3

Structurei

Secondary structure

1229
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 13Combined sources10
Beta strandi18 – 23Combined sources6
Helixi28 – 39Combined sources12
Turni43 – 45Combined sources3
Beta strandi46 – 51Combined sources6
Beta strandi53 – 60Combined sources8
Beta strandi65 – 67Combined sources3
Turni68 – 72Combined sources5
Beta strandi77 – 83Combined sources7
Helixi137 – 143Combined sources7
Beta strandi151 – 154Combined sources4
Beta strandi162 – 170Combined sources9
Beta strandi173 – 177Combined sources5
Beta strandi179 – 187Combined sources9
Beta strandi189 – 195Combined sources7
Beta strandi207 – 211Combined sources5
Helixi213 – 215Combined sources3
Beta strandi216 – 219Combined sources4

3D structure databases

ProteinModelPortaliQ20728
SMRiQ20728
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ20728

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini170 – 212CAP-GlyPROSITE-ProRule annotationAdd BLAST43

Sequence similaritiesi

Belongs to the TBCB family.Curated

Phylogenomic databases

eggNOGiKOG3206 Eukaryota
ENOG410YKGB LUCA
GeneTreeiENSGT00760000119173
HOGENOMiHOG000209180
InParanoidiQ20728
KOiK17262
OMAiYNEEEMQ
OrthoDBiEOG091G0M22
PhylomeDBiQ20728

Family and domain databases

Gene3Di2.30.30.190, 1 hit
InterProiView protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF01302 CAP_GLY, 1 hit
PF14560 Ubiquitin_2, 1 hit
SMARTiView protein in SMART
SM01052 CAP_GLY, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
SSF74924 SSF74924, 1 hit
PROSITEiView protein in PROSITE
PS00845 CAP_GLY_1, 1 hit
PS50245 CAP_GLY_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q20728-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEVYDLEIT TNATDFPMEK KYPAGMSLND LKKKLELVVG TTVDSMRIQL
60 70 80 90 100
FDGDDQLKGE LTDGAKSLKD LGVRDGYRIH AVDVTGGNED FKDESMVEKY
110 120 130 140 150
EMSDDTYGKR TDSVRAWKKK MQEEQGSAAP MENESDKLNE EAAKNIMVGN
160 170 180 190 200
RCEVTVGAQM ARRGEVAYVG ATKFKEGVWV GVKYDEPVGK NDGSVAGVRY
210 220
FDCDPKYGGF VRPVDVKVGD FPELSIDEI
Length:229
Mass (Da):25,441
Last modified:November 1, 1996 - v1
Checksum:iC465365DAE378A0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z77663 Genomic DNA Translation: CAB01212.1
PIRiT22581
RefSeqiNP_506367.1, NM_073966.1
UniGeneiCel.3444

Genome annotation databases

EnsemblMetazoaiF53F4.3; F53F4.3; WBGene00009987
GeneIDi186176
KEGGicel:CELE_F53F4.3
UCSCiF53F4.3 c. elegans

Similar proteinsi

Entry informationi

Entry nameiTBCB_CAEEL
AccessioniPrimary (citable) accession number: Q20728
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 22, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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