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UniProtKB - Q20616 (SKPO1_CAEEL)

Entry version 145 (29 Sep 2021)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
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Protein

Peroxidase skpo-1

Gene

skpo-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in hypodermal immune response against some types of bacterial infection. Probably utilizes H2O2 produced by the NADPH oxidase bli-3. May play a role in cuticule biosynthesis.

1 Publication1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei222Proton acceptorPROSITE-ProRule annotation1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei332Transition state stabilizerPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi428Iron (heme axial ligand)PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • heme binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW
  • peroxidase activity Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processImmunity, Innate immunity
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-CEL-209968, Thyroxine biosynthesis
R-CEL-6798695, Neutrophil degranulation
R-CEL-8941413, Events associated with phagocytolytic activity of PMN cells

Protein family/group databases

PeroxiBase, a peroxidase database

More...PeroxiBasei		4139, CelPxd03

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxidase skpo-11 Publication (EC:1.11.1.7By similarity)
Alternative name(s):
ShKT and peroxidase domain-containing protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:skpo-1Imported
ORF Names:F49E12.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...WormBasei		F49E12.1 ; CE03378 ; WBGene00009897 ; skpo-1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Knockouts show increased susceptibility to infection with E.faecalis but not with P.aeruginosa, increased levels of H2O2 upon infection and a slightly shorter life span. Fertile animals show a bagging phenotype due to embryos being retained in the body and an increase of clec-60 mRNA levels upon infection. 50% of knockouts also have a dumpy phenotype. RNAi-mediated knockdown of the protein also results in higher susceptibility to infection by E.faecalis but not in a decreased life span or morphological changes.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000043123920 – 655Peroxidase skpo-1Sequence analysisAdd BLAST636

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi22 ↔ 56PROSITE-ProRule annotation
Disulfide bondi29 ↔ 49PROSITE-ProRule annotation
Disulfide bondi38 ↔ 53PROSITE-ProRule annotation
Disulfide bondi133 ↔ 150PROSITE-ProRule annotation
Disulfide bondi520 ↔ 576PROSITE-ProRule annotation
Disulfide bondi617 ↔ 642PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q20616

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q20616

PeptideAtlas

More...PeptideAtlasi		Q20616

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Exclusively expressed in hypodermis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		WBGene00009897, Expressed in adult organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		39669, 2 interactors

STRING: functional protein association networks

More...STRINGi		6239.F49E12.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q20616

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 56ShKTPROSITE-ProRule annotationAdd BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peroxidase family. XPO subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2408, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006087_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q20616

Identification of Orthologs from Complete Genome Data

More...OMAi		CQTGDNM

Database of Orthologous Groups

More...OrthoDBi		276568at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q20616

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.640.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019791, Haem_peroxidase_animal
IPR010255, Haem_peroxidase_sf
IPR037120, Haem_peroxidase_sf_animal
IPR003582, ShKT_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03098, An_peroxidase, 1 hit
PF01549, ShK, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00457, ANPEROXIDASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00254, ShKT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48113, SSF48113, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50292, PEROXIDASE_3, 1 hit
PS51670, SHKT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q20616-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSLLFSILL IYLIQLVRSE ECTDKHIHCF FWSQEGECEV NPRWMKKHCQ 
        60         70         80         90        100
KACGTCSLTS PTPLTRQQDV PTARTFDDQQ DRQFLPSRPS SIPEGCNSVM 
       110        120        130        140        150
TVEAETRRIF SSGQLTARFR QQMCAEEQVA PDCSINQCFH KKYRSMDGTC 
       160        170        180        190        200
NNLQNPVKGA AFTAFTRLMP AAYDDGFNTL VSASRRNRPN PREVSVFLLS 
       210        220        230        240        250
SERSLPGHVN SLLMLFGQFV SHDITSNAAQ NFCGCQNSGP MCASIFAPPS 
       260        270        280        290        300
DRSRRCIPFT RSFPICGTGQ FGRVREQLNM NTAAIDASLI YGSEAITARS 
       310        320        330        340        350
LRFAAMLRTS MIGGRMFPPN TNPGSLTAGD GRAILFVGLA ALHTSFLRLH 
       360        370        380        390        400
NNVAARLQNM NRHWNADRIF QESRKIVGGI VQVITYQEFV PELIGDASKT 
       410        420        430        440        450
ILGAYNGYNP NVEIGVLNEF AAGAYRLHGM IQETYPLVNS QFQEVNRYRF 
       460        470        480        490        500
IDGVNNINHV LNNIDAIYRG MMTVPVRSPQ RLTTSVTERL FGGSVDMAAV 
       510        520        530        540        550
NIQRGRDHGL RSYNDYRRFC NLRPITSFND WPEVPDENVR QRIGQLYRTP 
       560        570        580        590        600
DDLDFYVGGI LEQPAAGSLL GATFACVIGK QFERLRDGDR FYYENPGVFT 
       610        620        630        640        650
SPQLAELKRT TLSWVLCQTG DNMVRVGRRA FDIENGSRAV PCSSITGLNL 

EAWRE
Length:655
Mass (Da):73,496
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC8225BAFF8E2164E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z66520 Genomic DNA Translation: CAA91388.1

Protein sequence database of the Protein Information Resource

More...PIRi		T22448

NCBI Reference Sequences

More...RefSeqi		NP_495768.1, NM_063367.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		F49E12.1.1; F49E12.1.1; WBGene00009897

Database of genes from NCBI RefSeq genomes

More...GeneIDi		174340

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		cel:CELE_F49E12.1

UCSC genome browser

More...UCSCi		F49E12.1, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z66520 Genomic DNA Translation: CAA91388.1
PIRiT22448
RefSeqiNP_495768.1, NM_063367.5

3D structure databases

SMRiQ20616
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi39669, 2 interactors
STRINGi6239.F49E12.1

Protein family/group databases

PeroxiBasei4139, CelPxd03

Proteomic databases

EPDiQ20616
PaxDbiQ20616
PeptideAtlasiQ20616

Genome annotation databases

EnsemblMetazoaiF49E12.1.1; F49E12.1.1; WBGene00009897
GeneIDi174340
KEGGicel:CELE_F49E12.1
UCSCiF49E12.1, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		174340
WormBaseiF49E12.1 ; CE03378 ; WBGene00009897 ; skpo-1

Phylogenomic databases

eggNOGiKOG2408, Eukaryota
HOGENOMiCLU_006087_4_0_1
InParanoidiQ20616
OMAiCQTGDNM
OrthoDBi276568at2759
PhylomeDBiQ20616

Enzyme and pathway databases

ReactomeiR-CEL-209968, Thyroxine biosynthesis
R-CEL-6798695, Neutrophil degranulation
R-CEL-8941413, Events associated with phagocytolytic activity of PMN cells

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q20616

Gene expression databases

BgeeiWBGene00009897, Expressed in adult organism and 5 other tissues

Family and domain databases

Gene3Di1.10.640.10, 1 hit
InterProiView protein in InterPro
IPR019791, Haem_peroxidase_animal
IPR010255, Haem_peroxidase_sf
IPR037120, Haem_peroxidase_sf_animal
IPR003582, ShKT_dom
PfamiView protein in Pfam
PF03098, An_peroxidase, 1 hit
PF01549, ShK, 1 hit
PRINTSiPR00457, ANPEROXIDASE
SMARTiView protein in SMART
SM00254, ShKT, 1 hit
SUPFAMiSSF48113, SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS50292, PEROXIDASE_3, 1 hit
PS51670, SHKT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSKPO1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q20616
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 26, 2014
Last sequence update: November 1, 1996
Last modified: September 29, 2021
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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