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Protein

26S proteasome non-ATPase regulatory subunit 6

Gene

rpn-7

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CEL-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-CEL-174113 SCF-beta-TrCP mediated degradation of Emi1
R-CEL-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-CEL-4608870 Asymmetric localization of PCP proteins
R-CEL-5632684 Hedgehog 'on' state
R-CEL-5668541 TNFR2 non-canonical NF-kB pathway
R-CEL-5689603 UCH proteinases
R-CEL-5689880 Ub-specific processing proteases
R-CEL-6798695 Neutrophil degranulation
R-CEL-68949 Orc1 removal from chromatin
R-CEL-69229 Ubiquitin-dependent degradation of Cyclin D1
R-CEL-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8939902 Regulation of RUNX2 expression and activity
R-CEL-8941858 Regulation of RUNX3 expression and activity
R-CEL-8948751 Regulation of PTEN stability and activity
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 6
Alternative name(s):
26S proteasome regulatory subunit rpn-7
Gene namesi
Name:rpn-7
ORF Names:F49C12.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF49C12.8 ; CE03368 ; WBGene00004463 ; rpn-7

Subcellular locationi

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001738401 – 41026S proteasome non-ATPase regulatory subunit 6Add BLAST410

Proteomic databases

EPDiQ20585
PaxDbiQ20585
PeptideAtlasiQ20585
PRIDEiQ20585

Expressioni

Tissue specificityi

Expressed in multiple tissues including the intestine, pharynx and hypodermis.1 Publication

Gene expression databases

BgeeiWBGene00004463

Interactioni

Protein-protein interaction databases

BioGridi42859, 3 interactors
DIPiDIP-26993N
IntActiQ20585, 3 interactors
STRINGi6239.F49C12.8.1

Structurei

3D structure databases

ProteinModelPortaliQ20585
SMRiQ20585
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini207 – 382PCIPROSITE-ProRule annotationAdd BLAST176

Sequence similaritiesi

Belongs to the proteasome subunit S10 family.Curated

Phylogenomic databases

eggNOGiKOG0687 Eukaryota
COG5187 LUCA
GeneTreeiENSGT00510000046608
HOGENOMiHOG000214998
InParanoidiQ20585
KOiK03037
OMAiVDYIDQE
OrthoDBiEOG091G03SE
PhylomeDBiQ20585

Family and domain databases

InterProiView protein in InterPro
IPR000717 PCI_dom
IPR035268 PSMD6
IPR019585 Rpn7/CSN1
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR14145:SF1 PTHR14145:SF1, 1 hit
PfamiView protein in Pfam
PF01399 PCI, 1 hit
PF10602 RPN7, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequencei

Sequence statusi: Complete.

Q20585-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEAAKKSTK KPVDDGNFDK EIISRWPDLE LSQTRFMLNH PEVDSSVKEA
60 70 80 90 100
KLEKLQETIK EFDMAPFYEL VCADFKIVVD ATQLAAMKAA NQKKIDEITA
110 120 130 140 150
EVEDAEKNLG ESEVRQGLLR KFEYYCQIGD KDNALKAYTA TYEKTVGMGY
160 170 180 190 200
RIDVVFAMIR VGLFFLDHHL INKFITKAKE LMEQGGDWER KNRLRSYEAL
210 220 230 240 250
YRMSVRDFAG AADLFLEAVP TFGSYELMTY ENLILYTVIT TTFALDRPDL
260 270 280 290 300
RTKVIRCNEV QEQLTGGGLN GTLIPVREYL ESYYDCHYDR FFIQLAALES
310 320 330 340 350
ERFKFDRYLS PHFNYYSRGM RHRAYEQFLT PYKTVRIDMM AKDFGVSRAF
360 370 380 390 400
IDRELHRLIA TGQLQCRIDA VNGVIEVNHR DSKNHLYKAV IKDGDILLNR
410
IQKLARVINA
Length:410
Mass (Da):47,584
Last modified:November 1, 1996 - v1
Checksum:iF37390A3250109EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68227 Genomic DNA Translation: CAA92512.1
PIRiT22413
RefSeqiNP_501632.1, NM_069231.6
UniGeneiCel.12443

Genome annotation databases

EnsemblMetazoaiF49C12.8; F49C12.8; WBGene00004463
GeneIDi177753
KEGGicel:CELE_F49C12.8
UCSCiF49C12.8 c. elegans

Similar proteinsi

Entry informationi

Entry nameiPSMD6_CAEEL
AccessioniPrimary (citable) accession number: Q20585
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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