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Entry version 123 (13 Nov 2019)
Sequence version 2 (01 Jun 1998)
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Protein

Mediator of RNA polymerase II transcription subunit 12

Gene

dpy-22

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Functions downstream of let-60 during vulval induction. Required for asymmetric division of T-cells and for hypodermal development.By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q20497

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 12
Alternative name(s):
CeTRAP230
Mediator complex subunit 12
Protein dumpy-22
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dpy-22
Synonyms:mdt-12, psa-6, sop-1
ORF Names:F47A4.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
F47A4.2 ; CE16058 ; WBGene00001081 ; dpy-22

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1040E → K in os26; impairs asymmetric division of T-cells. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003129621 – 3498Mediator of RNA polymerase II transcription subunit 12Add BLAST3498

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q20497

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q20497

PeptideAtlas

More...
PeptideAtlasi
Q20497

PRoteomics IDEntifications database

More...
PRIDEi
Q20497

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in vulval precursor cells, the anchor cell and the hyp7 cell at the time of vulval fate specification and throughout vulval development. Expressed from the 8-cell stage of embryogenesis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001081 Expressed in 5 organ(s), highest expression level in material anatomical entity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Mediator complex.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
46109, 18 interactors

STRING: functional protein association networks

More...
STRINGi
6239.F47A4.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q20497

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2142 – 3498Required for nuclear localizationAdd BLAST1357

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili539 – 570Sequence analysisAdd BLAST32
Coiled coili2203 – 2290Sequence analysisAdd BLAST88
Coiled coili2395 – 2420Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2554 – 2714Glu-richAdd BLAST161
Compositional biasi2718 – 3497Gln-richAdd BLAST780

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mediator complex subunit 12 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3598 Eukaryota
ENOG410XP2V LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000037505

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113519

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q20497

KEGG Orthology (KO)

More...
KOi
K15162

Identification of Orthologs from Complete Genome Data

More...
OMAi
ICEQDWV

Database of Orthologous Groups

More...
OrthoDBi
66382at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019035 Mediator_Med12
IPR021990 Mediator_Med12_LCEWAV

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09497 Med12, 1 hit
PF12145 Med12-LCEWAV, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01281 Med12, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q20497-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRKTNLRMG TADVYKQNKN QEEDMLTTER LKKGYQMPLT QYELQSLVFN
60 70 80 90 100
ASENKLIRLE KAQKRSQSMI ASVIHKKGEF HMNYDRERKI PKEQLPCFAP
110 120 130 140 150
HNWKRILSDR VKFFSALARG TPLQQLSQRI PGFRRKELLF LEFSDYNISY
160 170 180 190 200
DRAIWCVKLL CILGFNSSSK TQKKTLLDVA TLELSQACNK TTIWLVTQLY
210 220 230 240 250
KSFRNPIKRR EATKTWNYLT GFMKYMFDDG VLDKQEFLND LTEVFNQLFL
260 270 280 290 300
QKNFKNPSVL STFMKYYVYF VEDLSSSLVL ARRSSTLLCQ ALGFLFEMAQ
310 320 330 340 350
DKRKIDAYYD SANKTFIKKE FENEDGEIYE FEDYDDFIDM LDEIPDVPYF
360 370 380 390 400
DETDKTPEAQ AEELIKQHEK RKAGSLKKSE RRRRRGLSKN RPKKMPQNPS
410 420 430 440 450
NEASLDHDKV QIKQEPMDYD EYGGQQSDNS MDYDSFSHQY DPSYEPLPFK
460 470 480 490 500
PLHTDIPKKL TDDEEFKYMK IGKRSVTPER ISGRYGSMTY PFWIQQGGVG
510 520 530 540 550
IDPPKDEVLD FSNPTPTETV NTQPQIDFES SPSASPALSV DKENECEKKE
560 570 580 590 600
DESKTKEKNK DKEKDKEKEK SVDEHTNDLD VPINPDDAEM ADANDKTDAS
610 620 630 640 650
EKQKLVEEEP TGKENEDDTS SKTAKTSTSA EKSEAPSIVD SNDKIDKEPN
660 670 680 690 700
ASSTSNDETS KDDTVPMESD PPAATEKPKE STEITTEEPL EVDKAPEVDK
710 720 730 740 750
SEKEHEDDIM IIESNKKADE DDCVVIAVVD PDQEQTPESE KKKDGEEERD
760 770 780 790 800
KNKDTDVADN EPEKIYTDEE LAEIKIRKEK EMKIATLASH IKEKMVSDKK
810 820 830 840 850
WKEKTSHAGW RTLDQCSQFS EALHLLSSMV QYMACVTPES FVWNDLSVQQ
860 870 880 890 900
EERRHRILPQ LCGSPLDYLP CELHKLPVME GVEEVVDCLR LRHCEIVRRS
910 920 930 940 950
QAAEDRWLPN AAFLQSFGRI IDTCVDVIGI MDNIDVEKPN AITNAGLRLF
960 970 980 990 1000
AFREKFEKQE ALLKTMLMFK WCITEEREGS FRATYIAKLL RFGMDQNPEN
1010 1020 1030 1040 1050
TIGGWQVMDL FFKFMSTEGP KHGSKMYQAH FDSTVAIMIE MMREKIFSIT
1060 1070 1080 1090 1100
DILRELEKDS DLDYNAPLME RQRKQKIPKI SKRHRKPETP DDTKLVHFTT
1110 1120 1130 1140 1150
EYTPKRLFMG KKMDLLERMI IILPQLDVDE DTDEYRLRRL LLFGLKPAAN
1160 1170 1180 1190 1200
VYFRRARAIY KSITKEFTTR LYIEFDRSSK VTTAHKKINQ NRLDDLLRQF
1210 1220 1230 1240 1250
RAQTYHDQHL ILERIVYNFI DGIGGFLKKN CDDVPAPEVA NIICEMYEFS
1260 1270 1280 1290 1300
MDITSIFDFF EMVNPYLKAV DDKIAHFRMD VLPDMYYTET AFIFVSFFMK
1310 1320 1330 1340 1350
HWQRFLLHPR ACAIVNQCFV LIQDMIRADD HMITCWGRTV AIFVFHARKA
1360 1370 1380 1390 1400
IANAGLQNEE FLAEDSHFWR VFPNAQHVDL DVGYFNEDFA GVKLQLRGGT
1410 1420 1430 1440 1450
LRYDSYNDFK WLVSNMKPNL KKKPHLKRPN TRYSFVVRAF MEARQHGRNF
1460 1470 1480 1490 1500
DRINELANYC ANITANDPPL SEYWIGAIKG LCFLSLDAPY PFKEMSQQID
1510 1520 1530 1540 1550
ISDCSTHYSL TTFITCLAGK SAFYIPRLLA ELTKHVFPLM LRHDGRLTSQ
1560 1570 1580 1590 1600
KTHDVKRKVA SKTTESRTLS EAEPGVCLCL LIICGLCCVG DEPFGLSVHY
1610 1620 1630 1640 1650
RGIEKKKKRF NNTADERIMH LFHWFEMDHA MFRTLGHISQ LLEALQSRCR
1660 1670 1680 1690 1700
DANLVLPKNF PIKNPPKHQQ ELHREKAPYR PQYLFNIAKT VQFVICEQDW
1710 1720 1730 1740 1750
VTLRMFRFFQ TRKMEAFNQD KLKQNCLGQQ ILRMALRRRT ERENVHKLFE
1760 1770 1780 1790 1800
AHKISKKATV DKVLSFMNLW NFRATLFDLM LMIKEISPDG NSRHAQQGAI
1810 1820 1830 1840 1850
AADALMSEIG KCCRDMFLSA YKTKIKMPIA KTLTDFRLSD INKFWLIAPL
1860 1870 1880 1890 1900
VRMCPKPINI PPQYANTTVG TVAAKFLREA ALLMDTPPTT PKERLLQCSW
1910 1920 1930 1940 1950
AMSKVPFINM ILTCLQCEKM QQSKDVFLQS LYTQLQRETL RDHHRRSNWT
1960 1970 1980 1990 2000
NRREHRDCTI FRITLIGYIY KEILKATHVE TWGLLIFQLM FHGIINPVRE
2010 2020 2030 2040 2050
KLIYETCFDM LHHMVLWTLV DGDSMNQHDR YGSIRVRWPQ YAGLMKKIRK
2060 2070 2080 2090 2100
EMQERFTDQT RNSLHRFLPI GKMQMSTISY KKYQKRPKVN QKMSKKFLAG
2110 2120 2130 2140 2150
EGLKNGKYSF LPEEKAKTNA FEHTDHLGDL IVKGGWKFRM FQTTRLDKVA
2160 2170 2180 2190 2200
KNVQNVLRSN MHHTHVLEFN RPQLLMSDNM FDDIFLAPPD IEITKIIEQP
2210 2220 2230 2240 2250
VPVIDEEEAK KRAEEEKEAA EKKEESKNAE DEKNKNNAEN KKDTKEGEKG
2260 2270 2280 2290 2300
KSKDKEKDGE KEKCKDASKK DDVTSEKNEL EKRASDAAAA TNAPETNKDM
2310 2320 2330 2340 2350
DTSTPKPAPV TRSPATRGRG GGRKRNSGAR GGGPRAKRAN SRADTAQAAA
2360 2370 2380 2390 2400
ATTQWNAPIA NTSNPAAGGN FHAAMRGNQP PMSNGSSDET KVHIRNLLNR
2410 2420 2430 2440 2450
KKEEKRNSLA DASAAAAAAN SNAMGNTSSM PPSGPPMPMG SSMQSAGATQ
2460 2470 2480 2490 2500
QLQGMQKHQM GGSMSGMNQN MGGMNQSMSH QAPPPYSSTN EMNRPLMNQY
2510 2520 2530 2540 2550
GGPHFAAPNP GPLNRSSGPV SSETRQQIME QQMREKLAAH HQLVEQQKQR
2560 2570 2580 2590 2600
DAREREARER EAREHQERMQ REAYMKEQQL LERKRAIEEN NRIMEEQQRE
2610 2620 2630 2640 2650
REMEAARKEA ARRAAEEAYA AEQQRLELLR RQEEERLRKE AEERMRIQRE
2660 2670 2680 2690 2700
NEERVRQEQM RLEAEERERI RRAEEERIQK ELEDKVRREK EEAARQEKER
2710 2720 2730 2740 2750
QEQEARMREA REAELSRQRM EQQRRSQQNP YMNQQGQYSQ QPPPSYQQSS
2760 2770 2780 2790 2800
YPNNYQPGQQ GNQPPNYQQP SHQSMQQGHQ AGYQQTSNQM QMNMQQQQNR
2810 2820 2830 2840 2850
QQGGPQQSFS GPGGINQPSQ PGYSGYNQQG GQGQQGQMQQ QRNPFGNQQD
2860 2870 2880 2890 2900
MQQPGAAKLM HAKPNEAHAQ QYQHTQNQLS LAQKEKEKQY FQAKNLQASQ
2910 2920 2930 2940 2950
ANAQQQQQRF GDVVAGNVAG YGRPYGQQQL GASDQMGTSQ LPGASTSRMN
2960 2970 2980 2990 3000
QGSSNPQGGM QSYQQQQPVL GQPGPIQTGQ STQQQIPAQS QQQYNSGRPQ
3010 3020 3030 3040 3050
MHTTPTKNDM SARAPSGAMG QIANRMGHGT NPQGYGSTGQ NVPGGYQQGQ
3060 3070 3080 3090 3100
QQSGQGSYPQ AQQQQPNQYS GSNQQVGQQA QQQQQQPLNQ NVSQSQSAAQ
3110 3120 3130 3140 3150
FGRPSQDSAY QQSGYNQTGN QSYQRPDQQQ QGAQQNQWSG SNQAQNQLRS
3160 3170 3180 3190 3200
QQQAQQPLQQ PQQSQQFQQP AQQAKNPMAQ SAQYGGFGGQ QQGYDQQQQG
3210 3220 3230 3240 3250
QIAPQQAQNP QASQSYGQQQ TQQNRYGMGS SGYTANSGGS SNILNQSMEE
3260 3270 3280 3290 3300
SGLNQGFSGA SSNASSQQGG SSQMQQSGYG MPGNQMQMQQ NQKQQVQRGM
3310 3320 3330 3340 3350
PTGMGQTNMG QSGMGQSGMG QTGMSRSGLG GGIGQQGQQS QQPQQPQVSQ
3360 3370 3380 3390 3400
QQNQRGMNPG AQLPPYSTGQ QQHQPQQSQI SQQQQQQDQY RRMQAAQMQQ
3410 3420 3430 3440 3450
QPTAQGQQNR MGMPSQQQSG AAYSNQMQFQ GVRQGQQGMG GMGGSGQQQP
3460 3470 3480 3490
QTQPHGSNQY YQQQQDQRMQ QQPQQPGQQQ QHGYGMGQYP NQQPPNQY
Length:3,498
Mass (Da):400,779
Last modified:June 1, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i283FFC65A6B9E336
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z49888 Genomic DNA Translation: CAA90064.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T22330

NCBI Reference Sequences

More...
RefSeqi
NP_509645.1, NM_077244.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F47A4.2.1; F47A4.2.1; WBGene00001081

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
181194

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F47A4.2

UCSC genome browser

More...
UCSCi
F47A4.2 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49888 Genomic DNA Translation: CAA90064.1
PIRiT22330
RefSeqiNP_509645.1, NM_077244.3

3D structure databases

SMRiQ20497
ModBaseiSearch...

Protein-protein interaction databases

BioGridi46109, 18 interactors
STRINGi6239.F47A4.2

Proteomic databases

EPDiQ20497
PaxDbiQ20497
PeptideAtlasiQ20497
PRIDEiQ20497

Genome annotation databases

EnsemblMetazoaiF47A4.2.1; F47A4.2.1; WBGene00001081
GeneIDi181194
KEGGicel:CELE_F47A4.2
UCSCiF47A4.2 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
181194
WormBaseiF47A4.2 ; CE16058 ; WBGene00001081 ; dpy-22

Phylogenomic databases

eggNOGiKOG3598 Eukaryota
ENOG410XP2V LUCA
GeneTreeiENSGT00440000037505
HOGENOMiHOG000113519
InParanoidiQ20497
KOiK15162
OMAiICEQDWV
OrthoDBi66382at2759

Enzyme and pathway databases

SignaLinkiQ20497

Miscellaneous databases

Protein Ontology

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PROi
PR:Q20497

Gene expression databases

BgeeiWBGene00001081 Expressed in 5 organ(s), highest expression level in material anatomical entity

Family and domain databases

InterProiView protein in InterPro
IPR019035 Mediator_Med12
IPR021990 Mediator_Med12_LCEWAV
PfamiView protein in Pfam
PF09497 Med12, 1 hit
PF12145 Med12-LCEWAV, 1 hit
SMARTiView protein in SMART
SM01281 Med12, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMED12_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q20497
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 1998
Last modified: November 13, 2019
This is version 123 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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