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UniProtKB - Q20077 (Q20077_CAEEL)

Entry version 169 (25 May 2022)
Sequence version 2 (06 Dec 2005)
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Protein
Submitted name:

PhosphoInositide Four Kinase (PI-4 Kinase)

Gene

pifk-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinasePROSITE-ProRule annotationARBA annotation, Transferase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-CEL-1660514, Synthesis of PIPs at the Golgi membrane

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
PhosphoInositide Four Kinase (PI-4 Kinase)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pifk-1Imported
ORF Names:CELE_F35H12.4Imported, F35H12.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...WormBasei		F35H12.4 ; CE39249 ; WBGene00018076 ; pifk-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q20077

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q20077

PeptideAtlas

More...PeptideAtlasi		Q20077

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		WBGene00018076, Expressed in multi-cellular organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		6239.F35H12.4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q20077

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q20077

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 171PIK helicalInterPro annotationAdd BLAST171
Domaini397 – 665PI3K/PI4K catalyticInterPro annotationAdd BLAST269

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 22DisorderedSequence analysisAdd BLAST22
Regioni403 – 409G-loopPROSITE-ProRule annotation7
Regioni568 – 592Activation loopPROSITE-ProRule annotationAdd BLAST25

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0903, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00550000074892

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002446_6_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q20077

Identification of Orthologs from Complete Genome Data

More...OMAi		TEIIDVM

Database of Orthologous Groups

More...OrthoDBi		1147978at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q20077

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1070.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR001263, PI3K_accessory_dom
IPR015433, PI_Kinase

The PANTHER Classification System

More...PANTHERi		PTHR10048, PTHR10048, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00454, PI3_PI4_kinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00146, PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50290, PI3_4_KINASE_3, 1 hit
PS51545, PIK_HELICAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q20077-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSESDVEYT IKQPDLTDVP TQSAKNLADG TIIVGENDTS DKEIEIEKED 
        60         70         80         90        100
TTKPTHDRQS WTMRLISSES FNAPMAVEYL NSIQDKPSLT FLGKRLFDLP 
       110        120        130        140        150
EKDLDFYLPQ LMYLYVTKVD AASVSHAYIE ERNKKDAQFT VLCIWLLNCF 
       160        170        180        190        200
TKNVPNKYEN HALMLKSLLS RSNVPGTSQS ADNMITLSLD RLEETNWTVG 
       210        220        230        240        250
SSYGKSAGAL ARAAIQKEST LTAEHDSYEK SRCGPISTKL LTNQQNFIGR 
       260        270        280        290        300
LVYIGVKLTE HHLLSSKQEK TIALQSELSM LNSMLPNSVW IPFDFENTMF 
       310        320        330        340        350
NICVNESAVL NSKDKVPYVF FAEVIRSSPN YNSNIKTLSS VEPRIKKSQS 
       360        370        380        390        400
ESVLLKNKSY HDSTDPSIAV FAESWAEKKA RIRGSSRYEN HQKWDLIPVI 
       410        420        430        440        450
VKTGDDLSQE AFAQQLLFTF KDLWHEEGVP LYLRPYKIVC IGSDAGLIEP 
       460        470        480        490        500
VLDTLSLHQI KRHLTNVFRM NGNVTTPSLK HHFENVFGPV NSETYVNAQK 
       510        520        530        540        550
NFIQSTAAYS LVSYYLQLKD RHNGNILLDM DGHLIHIDYG FLLSSSPRNL 
       560        570        580        590        600
GFETAPFKLT TEIIDVMGGI DSDMFLYFKS LLLRGLMAAR KHHRRIVSLA 
       610        620        630        640        650
EIMSAGSKMQ CFRAGAETVR ALEARFHVSS TDEQLQQLVD TLVEGSRDSY 
       660 
TTRFYDSFQY YTNGIH
Length:666
Mass (Da):75,512
Last modified:December 6, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDDD31CB373D25022
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX284606 Genomic DNA Translation: CCD70618.1

Protein sequence database of the Protein Information Resource

More...PIRi		F89453

NCBI Reference Sequences

More...RefSeqi		NP_508177.2, NM_075776.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		F35H12.4.1; F35H12.4.1; WBGene00018076

Database of genes from NCBI RefSeq genomes

More...GeneIDi		180443

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		cel:CELE_F35H12.4

UCSC genome browser

More...UCSCi		F35H12.4, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CCD70618.1
PIRiF89453
RefSeqiNP_508177.2, NM_075776.4

3D structure databases

AlphaFoldDBiQ20077
SMRiQ20077
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.F35H12.4

Proteomic databases

EPDiQ20077
PaxDbiQ20077
PeptideAtlasiQ20077

Genome annotation databases

EnsemblMetazoaiF35H12.4.1; F35H12.4.1; WBGene00018076
GeneIDi180443
KEGGicel:CELE_F35H12.4
UCSCiF35H12.4, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		180443
WormBaseiF35H12.4 ; CE39249 ; WBGene00018076 ; pifk-1

Phylogenomic databases

eggNOGiKOG0903, Eukaryota
GeneTreeiENSGT00550000074892
HOGENOMiCLU_002446_6_0_1
InParanoidiQ20077
OMAiTEIIDVM
OrthoDBi1147978at2759
PhylomeDBiQ20077

Enzyme and pathway databases

ReactomeiR-CEL-1660514, Synthesis of PIPs at the Golgi membrane

Gene expression databases

BgeeiWBGene00018076, Expressed in multi-cellular organism and 4 other tissues

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR001263, PI3K_accessory_dom
IPR015433, PI_Kinase
PANTHERiPTHR10048, PTHR10048, 2 hits
PfamiView protein in Pfam
PF00454, PI3_PI4_kinase, 1 hit
SMARTiView protein in SMART
SM00146, PI3Kc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50290, PI3_4_KINASE_3, 1 hit
PS51545, PIK_HELICAL, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ20077_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q20077
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: December 6, 2005
Last modified: May 25, 2022
This is version 169 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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