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Entry version 114 (05 Jun 2019)
Sequence version 2 (01 Oct 2002)
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Protein
Submitted name:

MaLonyl CoA Decarboxylase

Gene

mlcd-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-390247 Beta-oxidation of very long chain fatty acids
R-CEL-9033241 Peroxisomal protein import

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MaLonyl CoA DecarboxylaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mlcd-1Imported
ORF Names:CELE_F35G12.1Imported, F35G12.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
F35G12.1a ; CE31498 ; WBGene00009439 ; mlcd-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q20048

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q20048

PeptideAtlas

More...
PeptideAtlasi
Q20048

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00009439 Expressed in 5 organ(s), highest expression level in germ line (C elegans)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

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DIPi
DIP-27406N

Protein interaction database and analysis system

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IntActi
Q20048, 2 interactors

STRING: functional protein association networks

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STRINGi
6239.F35G12.1a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q20048

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini63 – 150MCD_NInterPro annotationAdd BLAST88
Domaini153 – 415MCDInterPro annotationAdd BLAST263

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3018 Eukaryota
COG1593 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005410

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000141409

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q20048

KEGG Orthology (KO)

More...
KOi
K01578

Identification of Orthologs from Complete Genome Data

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OMAi
TGSCGLM

Database of Orthologous Groups

More...
OrthoDBi
1436590at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q20048

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.140.90, 1 hit
3.40.630.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038917 Malonyl_CoA_deC
IPR007956 Malonyl_CoA_deC_C
IPR042303 Malonyl_CoA_deC_C_sf
IPR035372 MCD_N
IPR038351 MCD_N_sf

The PANTHER Classification System

More...
PANTHERi
PTHR28641 PTHR28641, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05292 MCD, 1 hit
PF17408 MCD_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q20048-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRRYSHFYS IRYSSTLLST LDGLTNRTSG DKLLTYSEKF SKLYANSTPE
60 70 80 90 100
TRKSIFVDLV TNYGVNKEAL NHAISLYSKN DQMYPEVRTS ATASYVNLIK
110 120 130 140 150
SIGNLPGGVM QVCEMRANIL ALLKRETDKT TTSYLRHIEL ATREVLTSWF
160 170 180 190 200
SLGNLKLERL TWSSPGDILQ KVAEYEAVHP VRGLSDFRKR LGPLRRCFYF
210 220 230 240 250
SHEALPRNPL VMVHVALVDE IADSVQEITK RGAPTGKEED QTTAIYYSIT
260 270 280 290 300
STQPGLSGID LGNMLIKKVA TKLQKDVPSV TTHSTLSPIP GFRPWLIRNL
310 320 330 340 350
KGNSEYPSIM NEKVVNWISD ISEREMNEVE ATETLLKVIS NEKTKKEQLN
360 370 380 390 400
AIQHILMYAC AHYLCNAKRN GMALNSVANF HIRNGAELYR LNWNGDTSHR
410 420 430 440
GINNSFGIMV NYRYDLEKVH ENSAAYTEHK KMAINQKVLD IF
Length:442
Mass (Da):50,172
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE77D28EBDDE266A7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CAA86324.2

Protein sequence database of the Protein Information Resource

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PIRi
T21798

NCBI Reference Sequences

More...
RefSeqi
NP_001022561.1, NM_001027390.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F35G12.1a.1; F35G12.1a.1; WBGene00009439
F35G12.1a.2; F35G12.1a.2; WBGene00009439

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
175597

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F35G12.1

UCSC genome browser

More...
UCSCi
F35G12.1a c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CAA86324.2
PIRiT21798
RefSeqiNP_001022561.1, NM_001027390.5

3D structure databases

SMRiQ20048
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-27406N
IntActiQ20048, 2 interactors
STRINGi6239.F35G12.1a

Proteomic databases

EPDiQ20048
PaxDbiQ20048
PeptideAtlasiQ20048

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF35G12.1a.1; F35G12.1a.1; WBGene00009439
F35G12.1a.2; F35G12.1a.2; WBGene00009439
GeneIDi175597
KEGGicel:CELE_F35G12.1
UCSCiF35G12.1a c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
175597
WormBaseiF35G12.1a ; CE31498 ; WBGene00009439 ; mlcd-1

Phylogenomic databases

eggNOGiKOG3018 Eukaryota
COG1593 LUCA
GeneTreeiENSGT00390000005410
HOGENOMiHOG000141409
InParanoidiQ20048
KOiK01578
OMAiTGSCGLM
OrthoDBi1436590at2759
PhylomeDBiQ20048

Enzyme and pathway databases

ReactomeiR-CEL-390247 Beta-oxidation of very long chain fatty acids
R-CEL-9033241 Peroxisomal protein import

Gene expression databases

BgeeiWBGene00009439 Expressed in 5 organ(s), highest expression level in germ line (C elegans)

Family and domain databases

Gene3Di1.20.140.90, 1 hit
3.40.630.150, 1 hit
InterProiView protein in InterPro
IPR038917 Malonyl_CoA_deC
IPR007956 Malonyl_CoA_deC_C
IPR042303 Malonyl_CoA_deC_C_sf
IPR035372 MCD_N
IPR038351 MCD_N_sf
PANTHERiPTHR28641 PTHR28641, 1 hit
PfamiView protein in Pfam
PF05292 MCD, 1 hit
PF17408 MCD_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ20048_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q20048
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: October 1, 2002
Last modified: June 5, 2019
This is version 114 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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