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Entry version 96 (18 Sep 2019)
Sequence version 2 (20 Feb 2007)
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Protein

Izumo sperm-egg fusion protein 4

Gene

IZUMO4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Izumo is the name of a Japanese shrine to marriage.

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1300645 Acrosome Reaction and Sperm:Oocyte Membrane Binding

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.55.3.1 the izumo sperm-egg fusion protein 1 (izumo1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Izumo sperm-egg fusion protein 4
Alternative name(s):
Sperm 22 kDa protein c113
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IZUMO4
Synonyms:C19orf36
ORF Names:UNQ831/PRO1758
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26950 IZUMO4

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q1ZYL8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000099840

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165393578

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IZUMO4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
126215691

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 15Sequence analysisAdd BLAST15
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000027818616 – 232Izumo sperm-egg fusion protein 4Add BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi219N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q1ZYL8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q1ZYL8

PeptideAtlas

More...
PeptideAtlasi
Q1ZYL8

PRoteomics IDEntifications database

More...
PRIDEi
Q1ZYL8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61254 [Q1ZYL8-1]
61255 [Q1ZYL8-2]
61256 [Q1ZYL8-3]
61257 [Q1ZYL8-4]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in sperm.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000099840 Expressed in 142 organ(s), highest expression level in left testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q1ZYL8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q1ZYL8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA045099
HPA048496

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000378712

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q1ZYL8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Izumo family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J9T0 Eukaryota
ENOG41116R4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015418

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006488

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q1ZYL8

Identification of Orthologs from Complete Genome Data

More...
OMAi
SEKFSFY

Database of Orthologous Groups

More...
OrthoDBi
1110467at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q1ZYL8

TreeFam database of animal gene trees

More...
TreeFami
TF338561

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029389 IZUMO

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15005 IZUMO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q1ZYL8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALLLCLVCL TAALAHGCLH CHSNFSKKFS FYRHHVNFKS WWVGDIPVSG
60 70 80 90 100
ALLTDWSDDT MKELHLAIPA KITREKLDQV ATAVYQMMDQ LYQGKMYFPG
110 120 130 140 150
YFPNELRNIF REQVHLIQNA IIESRIDCQH RCGIFQYETI SCNNCTDSHV
160 170 180 190 200
ACFGYNCESS AQWKSAVQGL LNYINNWHKQ DTSMRPRSSA FSWPGTHRAT
210 220 230
PAFLVSPALR CLEPPHLANL TLEDAAECLK QH
Length:232
Mass (Da):26,510
Last modified:February 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i14FC9E0D37BA2ED4
GO
Isoform 2 (identifier: Q1ZYL8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     185-203: RPRSSAFSWPGTHRATPAF → S

Show »
Length:214
Mass (Da):24,486
Checksum:i25B5594E1177B334
GO
Isoform 3 (identifier: Q1ZYL8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-157: SRIDCQHRCGIFQYETISCNNCTDSHVACFGYNC → RHLAPGSWGGGQLSREGPSLAPEGSMPSPRGDLP
     158-232: Missing.

Show »
Length:157
Mass (Da):17,681
Checksum:iF8F99A2BA51C61F4
GO
Isoform 4 (identifier: Q1ZYL8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     159-232: Missing.

Show »
Length:158
Mass (Da):18,245
Checksum:iF4AA48B12133A6B8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1M1A0A087X1M1_HUMAN
Izumo sperm-egg fusion protein 4
IZUMO4
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X221A0A087X221_HUMAN
Izumo sperm-egg fusion protein 4
IZUMO4
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXR1A0A087WXR1_HUMAN
Izumo sperm-egg fusion protein 4
IZUMO4
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MS61A0A0A0MS61_HUMAN
Izumo sperm-egg fusion protein 4
IZUMO4
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X160A0A087X160_HUMAN
Izumo sperm-egg fusion protein 4
IZUMO4
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH10443 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0306832A → T2 PublicationsCorresponds to variant dbSNP:rs17851210Ensembl.1
Natural variantiVAR_05091138F → L. Corresponds to variant dbSNP:rs35585208Ensembl.1
Natural variantiVAR_061630137Y → F. Corresponds to variant dbSNP:rs45506200Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023147124 – 157SRIDC…FGYNC → RHLAPGSWGGGQLSREGPSL APEGSMPSPRGDLP in isoform 3. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_023148158 – 232Missing in isoform 3. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_023149159 – 232Missing in isoform 4. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_023150185 – 203RPRSS…ATPAF → S in isoform 2. 3 PublicationsAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY753639 mRNA Translation: AAX09280.1
DQ196309 mRNA Translation: ABA28617.1
DQ196310 mRNA Translation: ABA28618.1
DQ424900 mRNA Translation: ABD83665.1
AY358444 mRNA Translation: AAQ88809.1
BC010443 mRNA Translation: AAH10443.1 Different initiation.
BC014609 mRNA Translation: AAH14609.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35499.1 [Q1ZYL8-2]
CCDS42458.1 [Q1ZYL8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001026905.2, NM_001031735.2 [Q1ZYL8-2]
NP_001034935.1, NM_001039846.1 [Q1ZYL8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000395301; ENSP00000378712; ENSG00000099840 [Q1ZYL8-1]
ENST00000395307; ENSP00000378718; ENSG00000099840 [Q1ZYL8-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
113177

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:113177

UCSC genome browser

More...
UCSCi
uc002luw.2 human [Q1ZYL8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY753639 mRNA Translation: AAX09280.1
DQ196309 mRNA Translation: ABA28617.1
DQ196310 mRNA Translation: ABA28618.1
DQ424900 mRNA Translation: ABD83665.1
AY358444 mRNA Translation: AAQ88809.1
BC010443 mRNA Translation: AAH10443.1 Different initiation.
BC014609 mRNA Translation: AAH14609.1
CCDSiCCDS35499.1 [Q1ZYL8-2]
CCDS42458.1 [Q1ZYL8-1]
RefSeqiNP_001026905.2, NM_001031735.2 [Q1ZYL8-2]
NP_001034935.1, NM_001039846.1 [Q1ZYL8-1]

3D structure databases

SMRiQ1ZYL8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000378712

Protein family/group databases

TCDBi8.A.55.3.1 the izumo sperm-egg fusion protein 1 (izumo1) family

Polymorphism and mutation databases

BioMutaiIZUMO4
DMDMi126215691

Proteomic databases

MassIVEiQ1ZYL8
PaxDbiQ1ZYL8
PeptideAtlasiQ1ZYL8
PRIDEiQ1ZYL8
ProteomicsDBi61254 [Q1ZYL8-1]
61255 [Q1ZYL8-2]
61256 [Q1ZYL8-3]
61257 [Q1ZYL8-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
113177
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395301; ENSP00000378712; ENSG00000099840 [Q1ZYL8-1]
ENST00000395307; ENSP00000378718; ENSG00000099840 [Q1ZYL8-2]
GeneIDi113177
KEGGihsa:113177
UCSCiuc002luw.2 human [Q1ZYL8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
113177

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IZUMO4
HGNCiHGNC:26950 IZUMO4
HPAiHPA045099
HPA048496
neXtProtiNX_Q1ZYL8
OpenTargetsiENSG00000099840
PharmGKBiPA165393578

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J9T0 Eukaryota
ENOG41116R4 LUCA
GeneTreeiENSGT00390000015418
HOGENOMiHOG000006488
InParanoidiQ1ZYL8
OMAiSEKFSFY
OrthoDBi1110467at2759
PhylomeDBiQ1ZYL8
TreeFamiTF338561

Enzyme and pathway databases

ReactomeiR-HSA-1300645 Acrosome Reaction and Sperm:Oocyte Membrane Binding

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
113177

Pharos

More...
Pharosi
Q1ZYL8

Protein Ontology

More...
PROi
PR:Q1ZYL8

Gene expression databases

BgeeiENSG00000099840 Expressed in 142 organ(s), highest expression level in left testis
ExpressionAtlasiQ1ZYL8 baseline and differential
GenevisibleiQ1ZYL8 HS

Family and domain databases

InterProiView protein in InterPro
IPR029389 IZUMO
PfamiView protein in Pfam
PF15005 IZUMO, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIZUM4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1ZYL8
Secondary accession number(s): A7RA93
, A7RA94, Q6UXA2, Q96FT6, Q96L02
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: September 18, 2019
This is version 96 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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