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Entry version 110 (16 Oct 2019)
Sequence version 1 (18 Apr 2006)
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Protein

Vacuolar protein sorting-associated protein 39 homolog

Gene

vps-39

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways (By similarity). Believed to act in part as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (PubMed:25273556). The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:24374177). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes (By similarity). Required for fusion of endosomes (By similarity). In association with lgg-2 mediates the tethering of autophagosomes with lysosomes to form autolysosomes (PubMed:25126728, PubMed:24374177). Within the HOPS complex, contributes to the normal development of gut granules in embryonic and adult intestinal cells (PubMed:24501423).By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 39 homologCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:vps-39Imported
ORF Names:T08G5.5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
T08G5.5a ; CE18946 ; WBGene00011625 ; vps-39
T08G5.5b ; CE40122 ; WBGene00011625 ; vps-39
T08G5.5c ; CE41694 ; WBGene00011625 ; vps-39

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

In 1-cell to 20-cell stage embryos, there is defective autophagosome degradation with an accumulation of endosomes, lgg-1- and lgg-2-positive autophagosomes, amphisomes and paternal mitochondria close to the nuclei (PubMed:25126728, PubMed:24374177). Reduced number of gut granules in the adult intestine (PubMed:24501423). RNAi-mediated knockdown results in a reduced number of gut granules in embryonic intestinal cells (PubMed:24501423). RNAi-mediated knockdown results in the formation of large late endosomes/lysosomes, but with simultaneous expression of rab-5- and rab-7-positive vesicles on the basal side of gut cells (PubMed:25273556).4 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004412761 – 926Vacuolar protein sorting-associated protein 39 homologCuratedAdd BLAST926

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q1ZXS5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q1ZXS5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00011625 Expressed in 5 organ(s), highest expression level in adult organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Probable core component of the homotypic fusion and vacuole protein sorting (HOPS) complex consisting of the core class C Vps proteins vps-11, vps-16, vps-18, and which further associates with vps-33.1, vps-39 and vps-41 (By similarity). May interact with lgg-2 (PubMed:24374177).

By similarity1 Publication

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1136 HOPS complex

Database of interacting proteins

More...
DIPi
DIP-24817N

Protein interaction database and analysis system

More...
IntActi
Q1ZXS5, 29 interactors

STRING: functional protein association networks

More...
STRINGi
6239.T08G5.5b

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 306CNHPROSITE-ProRule annotationAdd BLAST292
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati590 – 768CHCRPROSITE-ProRule annotationAdd BLAST179

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VAM6/VPS39 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2063 Eukaryota
ENOG410XNSX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063596

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000012854

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q1ZXS5

KEGG Orthology (KO)

More...
KOi
K20183

Identification of Orthologs from Complete Genome Data

More...
OMAi
RTIRYLQ

Database of Orthologous Groups

More...
OrthoDBi
291710at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q1ZXS5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001180 CNH_dom
IPR032914 Vam6/VPS39/TRAP1
IPR019452 VPS39/TGF_beta_rcpt-assoc_1
IPR019453 VPS39/TGF_beta_rcpt-assoc_2
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12894 PTHR12894, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00780 CNH, 1 hit
PF10366 Vps39_1, 1 hit
PF10367 Vps39_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50219 CNH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform bImported (identifier: Q1ZXS5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYDAYTPCEV ALRLPVEVTC LAFQESNQTL LAGGRAGHLY AYTISANRRG
60 70 80 90 100
FELTNICKSF HKKAVMELKV CQREDLLLCV SDGQLMAHKL SDPEYKVETL
110 120 130 140 150
IHKVKPVQTF ARFSPKTSGD LYVIVSSRKK LYLFKWGEKD GHKEFIEVAL
160 170 180 190 200
DYNPVFLDTP TSIRCVGEMV FFSVRNEYFS MTMQKDKTTT SPSEGSTPEG
210 220 230 240 250
WNGFVTRLLN FNCQPGIVPM IDRRRVAFVR NEIVVTTDIW GQRPANVLSD
260 270 280 290 300
EYKFSEVPMQ IVYDSPYLVG MLSKGRVEVR SIFDGQLVQT MSLPKAMTLC
310 320 330 340 350
SGARGQVFVA ALSDIWILDT SQNLRKNVSH LIQERHFELA IQLAENSNLF
360 370 380 390 400
AEEQKLEIKK KAALNLFNQK KFDESFALFG EIKTDISEVL SIIRMFPELL
410 420 430 440 450
PDGFQSMTGV VSDMPANDRM RALLALGSYL SEIRTEHAKH IELYNRLYSS
460 470 480 490 500
GAAKKTDEDE KAKLLLTLRV VDTTLLKCYI KTKPMLVDSL IRLQSNACTF
510 520 530 540 550
EDAKKILESE GRLRSLFILY ETRKKHEMAL DLFIDQSSRP DADPFFDDAI
560 570 580 590 600
QQIVEYLQSL GNSNLPLILK YAKWVLAKNL EAGVQIFTSD ETEMARNLNR
610 620 630 640 650
KAVVEFLKSE CPDALIPYLE HVIFKWEEPS SYFHETLLEF YVARVNTLFK
660 670 680 690 700
DYVHAFPDAF SDENITRAGD EDGELGLYRK RLLKFLEVSH SYSPQTVLLQ
710 720 730 740 750
LAPHAFYEER ALILGRLKQH EQALAIYVNT LKNVPAAEEY CRLYYNAHDE
760 770 780 790 800
TNSQVYLMLF RTLVHPNQQQ LHSIPYHADS TPFGSYRDDV SEASTLVNST
810 820 830 840 850
SSYQPDVNTA IKILAKHADK IDTVGALNML PATTPLRVVF SAINAVIQTT
860 870 880 890 900
GRQASTRKME KSVSQCAMSK KLERKNKAQS TKIIVNFSSE CVVCEKKIAV
910 920
SAFVRYPDGR LAHLYCHNDS QGGNRN
Length:926
Mass (Da):105,256
Last modified:April 18, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i180A221D7B4FB49F
GO
Isoform aImported (identifier: Q1ZXS5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     659-661: Missing.

Show »
Length:923
Mass (Da):104,950
Checksum:i34BF7C0AB207F676
GO
Isoform cImported (identifier: Q1ZXS5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     385-387: Missing.
     659-661: Missing.

Show »
Length:920
Mass (Da):104,635
Checksum:i10BB42E711809EC3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A486WXM5A0A486WXM5_CAEEL
CNH domain-containing protein
vps-39 CELE_T08G5.5, T08G5.5
923Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_059058385 – 387Missing in isoform c. Curated3
Alternative sequenceiVSP_059059659 – 661Missing in isoform a and isoform c. Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAB04720.1
BX284605 Genomic DNA Translation: CAJ85769.1
BX284605 Genomic DNA Translation: CAP16526.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T24712

NCBI Reference Sequences

More...
RefSeqi
NP_001041163.1, NM_001047698.2 [Q1ZXS5-2]
NP_001041164.1, NM_001047699.4 [Q1ZXS5-1]
NP_001123010.1, NM_001129538.2 [Q1ZXS5-3]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T08G5.5a.1; T08G5.5a.1; WBGene00011625 [Q1ZXS5-2]
T08G5.5b.1; T08G5.5b.1; WBGene00011625 [Q1ZXS5-1]
T08G5.5c.1; T08G5.5c.1; WBGene00011625 [Q1ZXS5-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
179902

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_T08G5.5

UCSC genome browser

More...
UCSCi
T08G5.5b c. elegans [Q1ZXS5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAB04720.1
BX284605 Genomic DNA Translation: CAJ85769.1
BX284605 Genomic DNA Translation: CAP16526.1
PIRiT24712
RefSeqiNP_001041163.1, NM_001047698.2 [Q1ZXS5-2]
NP_001041164.1, NM_001047699.4 [Q1ZXS5-1]
NP_001123010.1, NM_001129538.2 [Q1ZXS5-3]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

ComplexPortaliCPX-1136 HOPS complex
DIPiDIP-24817N
IntActiQ1ZXS5, 29 interactors
STRINGi6239.T08G5.5b

Proteomic databases

EPDiQ1ZXS5
PaxDbiQ1ZXS5

Genome annotation databases

EnsemblMetazoaiT08G5.5a.1; T08G5.5a.1; WBGene00011625 [Q1ZXS5-2]
T08G5.5b.1; T08G5.5b.1; WBGene00011625 [Q1ZXS5-1]
T08G5.5c.1; T08G5.5c.1; WBGene00011625 [Q1ZXS5-3]
GeneIDi179902
KEGGicel:CELE_T08G5.5
UCSCiT08G5.5b c. elegans [Q1ZXS5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
179902
WormBaseiT08G5.5a ; CE18946 ; WBGene00011625 ; vps-39
T08G5.5b ; CE40122 ; WBGene00011625 ; vps-39
T08G5.5c ; CE41694 ; WBGene00011625 ; vps-39

Phylogenomic databases

eggNOGiKOG2063 Eukaryota
ENOG410XNSX LUCA
GeneTreeiENSGT00530000063596
HOGENOMiHOG000012854
InParanoidiQ1ZXS5
KOiK20183
OMAiRTIRYLQ
OrthoDBi291710at2759
PhylomeDBiQ1ZXS5

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q1ZXS5

Gene expression databases

BgeeiWBGene00011625 Expressed in 5 organ(s), highest expression level in adult organism

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR001180 CNH_dom
IPR032914 Vam6/VPS39/TRAP1
IPR019452 VPS39/TGF_beta_rcpt-assoc_1
IPR019453 VPS39/TGF_beta_rcpt-assoc_2
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR12894 PTHR12894, 1 hit
PfamiView protein in Pfam
PF00780 CNH, 1 hit
PF10366 Vps39_1, 1 hit
PF10367 Vps39_2, 1 hit
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50219 CNH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVPS39_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1ZXS5
Secondary accession number(s): A8JJR1, Q9XUQ4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2017
Last sequence update: April 18, 2006
Last modified: October 16, 2019
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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