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Entry version 73 (16 Oct 2019)
Sequence version 1 (02 May 2006)
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Protein

Probable serine/threonine-protein kinase DDB_G0278845

Gene

DDB_G0278845

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei785ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei880Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi762 – 770ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-2028269 Signaling by Hippo

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable serine/threonine-protein kinase DDB_G0278845 (EC:2.7.11.1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:DDB_G0278845
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0278845

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003589011 – 1350Probable serine/threonine-protein kinase DDB_G0278845Add BLAST1350

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q1ZXI5

PRoteomics IDEntifications database

More...
PRIDEi
Q1ZXI5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0231558

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini756 – 1082Protein kinasePROSITE-ProRule annotationAdd BLAST327
Domaini1083 – 1203AGC-kinase C-terminalAdd BLAST121

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi31 – 41Poly-AsnAdd BLAST11
Compositional biasi99 – 107Poly-Asn9
Compositional biasi181 – 197Poly-AsnAdd BLAST17
Compositional biasi232 – 235Poly-Asn4
Compositional biasi268 – 271Poly-Ser4
Compositional biasi276 – 283Poly-Thr8
Compositional biasi351 – 382Poly-AsnAdd BLAST32
Compositional biasi528 – 535Poly-Asn8
Compositional biasi609 – 617Poly-Asn9
Compositional biasi620 – 627Poly-Asn8
Compositional biasi645 – 680Poly-AsnAdd BLAST36
Compositional biasi681 – 686Poly-Asp6
Compositional biasi1132 – 1139Poly-Pro8
Compositional biasi1204 – 1219Poly-AsnAdd BLAST16
Compositional biasi1231 – 1239Poly-Asn9
Compositional biasi1242 – 1282Poly-AsnAdd BLAST41
Compositional biasi1300 – 1307Poly-Asn8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0605 Eukaryota
ENOG410XQC0 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q1ZXI5

Identification of Orthologs from Complete Genome Data

More...
OMAi
IDYLQIN

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q1ZXI5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVFSLKESSD SISKPSSLKN STIIENPEIL NNNNNNNNSN NIIKSPNFLL
60 70 80 90 100
SQKQRSINIS NEQTQRELNN NGGNLDHRDP NSPKYLTSSH SSVVIPQDNS
110 120 130 140 150
NNNNNNNIRI STSPILTEIS ENGLLESPTS PIRTSSTPTT PTSPPFITSP
160 170 180 190 200
PFITSPKGLN SPRRLVGFFS KSTSYQSLLA NNNNNNNNSN NSNNNSNSSN
210 220 230 240 250
SNISCSNNSN KISRLINNSN TTDSNASIRS SNNNNDDFDN NDDEDLNSIN
260 270 280 290 300
NSSGIGIGVS SDYSLMGSSS SINGNTTTTT TNTYSYNDND NVNEYSPKGK
310 320 330 340 350
RLIRHEKSKS SPPLSPITPY YENLVIKGNY TNSNNYNNYN NYYYNNNSSG
360 370 380 390 400
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNISGNSGYN NSRDDLFKRP
410 420 430 440 450
FEMNKESSPT NSLIPNVSAL KLNRVIKSSN GSTIFTSTSS DIASENDNNK
460 470 480 490 500
NNENENENEN ENENENENEN DNDSDSENEN ENDNSIGNKS NKSNSELSIE
510 520 530 540 550
EQEKKKEKDL ENYINMINNS GFITNDSNNN NNNNNSGNNN SFISNGSPFS
560 570 580 590 600
PIKEESPQPS PTFSPKPTLQ RQRSNSKNVL YSPNASPSNS CKIPTPPLLH
610 620 630 640 650
NISIIDTSNN NNNNSNNIEN QNNNNNNIDN NIDNNIDSID KKLKNNNNNN
660 670 680 690 700
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN DDDDDDNNIK KTPNNKINTN
710 720 730 740 750
ENPMIITNSV LKRSGNIDYL QINNNYVIPS PSPGTQLSEC TNQQMKYNPP
760 770 780 790 800
VSIVDFTLIE KIGEGGFGQV FLAKKKDTGE IVAIKRMSKE LIWSKNKVSH
810 820 830 840 850
IKNERDILAQ GKNHRWIVSL VYSFQDDQYL YLAMEYVPGG DLRSLLSALN
860 870 880 890 900
SLDEDSARFY MAEMVEAVDS CHRLGYCHRD LKPENFLISR DGHVKLADFG
910 920 930 940 950
LSKNVVTRYH LRSASADNTI NTTTSTPTTS SNINQLSSSM IEHTPMKFGA
960 970 980 990 1000
AANGNGPLNS SVTDFGSFKD LSVAARLAYS VVGSPFYMAP EVLQATRGYG
1010 1020 1030 1040 1050
DEVDWWSLGC MFYEFIFGVP PFDGDSPEEV METVLKWKTM LQRPDGVSDE
1060 1070 1080 1090 1100
LWDLISGLIN DGSTRLGSGE KGVENIKNHI FFNGVPWGKL HDLDPPFVPL
1110 1120 1130 1140 1150
LQGDYDTTYF ENTEKLDNNF LLQQTQQLSL LPPPLPPPPQ TPTQPQQPSL
1160 1170 1180 1190 1200
PPQTPNDKMI FDKIRSPVVY TNTHSGNIIT SRSRPRNILG FTYPRADDQP
1210 1220 1230 1240 1250
LLWNNNNNNN NNNNNNNNNL LKNFEELTIL NNNNNKNKNK GNSNNNNNNN
1260 1270 1280 1290 1300
NNNNNNNNNN NNNNNNNNNN NNSNNNKNNS NNKTVTIPIS TGRLLNEIDN
1310 1320 1330 1340 1350
CNNNNNNDEN NINTGNLTPP NSSPFNSGEN LNFEKQEPTS PYGSYSKQQQ
Length:1,350
Mass (Da):150,420
Last modified:May 2, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA2F1C846751BBDE7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000024 Genomic DNA Translation: EAS66888.1

NCBI Reference Sequences

More...
RefSeqi
XP_001134572.1, XM_001134572.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAS66888; EAS66888; DDB_G0278845

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8621734

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0278845

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000024 Genomic DNA Translation: EAS66888.1
RefSeqiXP_001134572.1, XM_001134572.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi44689.DDB0231558

Proteomic databases

PaxDbiQ1ZXI5
PRIDEiQ1ZXI5

Genome annotation databases

EnsemblProtistsiEAS66888; EAS66888; DDB_G0278845
GeneIDi8621734
KEGGiddi:DDB_G0278845

Organism-specific databases

dictyBaseiDDB_G0278845

Phylogenomic databases

eggNOGiKOG0605 Eukaryota
ENOG410XQC0 LUCA
InParanoidiQ1ZXI5
OMAiIDYLQIN

Enzyme and pathway databases

ReactomeiR-DDI-2028269 Signaling by Hippo

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q1ZXI5

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 2 hits
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiY1558_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1ZXI5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: May 2, 2006
Last modified: October 16, 2019
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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