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Entry version 88 (02 Jun 2021)
Sequence version 1 (02 May 2006)
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Protein
Submitted name:

DNA repair protein Rad4 family protein

Gene

rad4

Organism
Dictyostelium discoideum (Slime mold)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repairARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-3108214, SUMOylation of DNA damage response and repair proteins
R-DDI-5696394, DNA Damage Recognition in GG-NER
R-DDI-5696395, Formation of Incision Complex in GG-NER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DNA repair protein Rad4 family proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rad4Imported
ORF Names:DDB_G0292296Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0292296, xpc

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q1ZXA6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0232368

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini743 – 795BHD_1InterPro annotationAdd BLAST53
Domaini797 – 844BHD_2InterPro annotationAdd BLAST48
Domaini852 – 926BHD_3InterPro annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 67DisorderedSequence analysisAdd BLAST67
Regioni164 – 202DisorderedSequence analysisAdd BLAST39
Regioni232 – 254DisorderedSequence analysisAdd BLAST23
Regioni321 – 595DisorderedSequence analysisAdd BLAST275

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi12 – 33Polar residuesSequence analysisAdd BLAST22
Compositional biasi36 – 67Acidic residuesSequence analysisAdd BLAST32
Compositional biasi179 – 202Polar residuesSequence analysisAdd BLAST24
Compositional biasi334 – 378Polar residuesSequence analysisAdd BLAST45
Compositional biasi393 – 443Basic and acidic residuesSequence analysisAdd BLAST51
Compositional biasi444 – 460Acidic residuesSequence analysisAdd BLAST17
Compositional biasi465 – 490Polar residuesSequence analysisAdd BLAST26
Compositional biasi511 – 581Basic and acidic residuesSequence analysisAdd BLAST71

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the XPC family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2179, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_306406_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q1ZXA6

Identification of Orthologs from Complete Genome Data

More...
OMAi
ARWKRFM

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.2460, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018327, BHD_2
IPR004583, DNA_repair_Rad4
IPR038765, Papain-like_cys_pep_sf
IPR018325, Rad4/PNGase_transGLS-fold
IPR018326, Rad4_beta-hairpin_dom1
IPR018328, Rad4_beta-hairpin_dom3
IPR042488, Rad4_BHD3_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12135, PTHR12135, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10403, BHD_1, 1 hit
PF10405, BHD_3, 1 hit
PF03835, Rad4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01030, BHD_1, 1 hit
SM01031, BHD_2, 1 hit
SM01032, BHD_3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001, SSF54001, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q1ZXA6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDYDDIEWEE SNNDNSTTTT TTTTTTASPR FDESINNEFD DEDKEEEGDI
60 70 80 90 100
NNSLDTDEEI GENQDDAGDA EDAIEFEIDT NEFKSKENGK KKRIVKKVDL
110 120 130 140 150
KEKHNCLYLH RTVLTCYLAN FKYTINVLSN QYLISIISSF IPKDLINLYS
160 170 180 190 200
NNYKIISEIK QIPTVDSTPQ KSRSRSKSKL DNTTTTTTTT TTTTTSNTTN
210 220 230 240 250
KKPPIPFMTC IDEIIKWFFS YFKIDEMADN LNSNNTDKNN KNNTNNKNKK
260 270 280 290 300
QTREVINLDD DNENTEERKK EKKFEPIRNS LLYYQLITQT KERKVTKKIF
310 320 330 340 350
VELFYMVCLI LGYKCRIIRP LSTPPPVPVT PSKLKRIASS SSPQAFSRSK
360 370 380 390 400
AKSSPSVIRL NYNIDDDNGN TNNNETKVKK SKSPSKTKTS ATSSTKKKID
410 420 430 440 450
DVISSKDKKN KEKKEKEKEI EREKEKEKDK KKSKKKSQFS FDSTDSEDEE
460 470 480 490 500
EEEEEEEEEL IISKPITSRQ KSIQANQFKN TVLNSKISKK TETTMSKKRK
510 520 530 540 550
TNSSLSSKNK KKNNSDSEND TDNERDSGSD NDDAGDKNNN KSDQEKDNSS
560 570 580 590 600
SDSDYKDSKK KLKRSSSEPI KRSRLSNLDD KESKTTTTTT TNTLSNNEKV
610 620 630 640 650
EIESWIEVFD HEKKKWISID LINKEIDKPL NFEKILDPFS YVVAISKYQI
660 670 680 690 700
KDVTSRYTNN YIGSSLKRLP IAQIKWWLQL VGDAINNPTE VENDNEPVSK
710 720 730 740 750
FILDSKKIIS VNIDLLNNLS IDERKSIEEI DVYEKQELII KESKLPFPSS
760 770 780 790 800
FAQFKSHPIF VLEKDIAKYC SPDPSSKPLG LFNETHKIYH KDQIKVLHTS
810 820 830 840 850
DKWVQNGRMV IEGQQPLKIV KGRSKSNPTS MLFGEWQTKL FEPAVIGKDG
860 870 880 890 900
IVPTNSFGNV YLFNSSMCPI NGVHLRGKGL IRVAKKLGIN FAPALTGWEN
910 920 930 940 950
GPKSSYPIID GVVVAKKFSK KLLDTWLSES SSRAEAELQK KNDEIKARWK
960
RFMKKLLIKN YIEKTYK
Length:967
Mass (Da):110,954
Last modified:May 2, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA832BFB5A83D8B65
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000189 Genomic DNA Translation: EAS66810.1

NCBI Reference Sequences

More...
RefSeqi
XP_001134493.1, XM_001134493.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAS66810; EAS66810; DDB_G0292296

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8628599

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0292296

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000189 Genomic DNA Translation: EAS66810.1
RefSeqiXP_001134493.1, XM_001134493.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi44689.DDB0232368

Proteomic databases

PaxDbiQ1ZXA6

Genome annotation databases

EnsemblProtistsiEAS66810; EAS66810; DDB_G0292296
GeneIDi8628599
KEGGiddi:DDB_G0292296

Organism-specific databases

dictyBaseiDDB_G0292296, xpc

Phylogenomic databases

eggNOGiKOG2179, Eukaryota
HOGENOMiCLU_306406_0_0_1
InParanoidiQ1ZXA6
OMAiARWKRFM

Enzyme and pathway databases

ReactomeiR-DDI-3108214, SUMOylation of DNA damage response and repair proteins
R-DDI-5696394, DNA Damage Recognition in GG-NER
R-DDI-5696395, Formation of Incision Complex in GG-NER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q1ZXA6

Family and domain databases

Gene3Di3.30.70.2460, 1 hit
InterProiView protein in InterPro
IPR018327, BHD_2
IPR004583, DNA_repair_Rad4
IPR038765, Papain-like_cys_pep_sf
IPR018325, Rad4/PNGase_transGLS-fold
IPR018326, Rad4_beta-hairpin_dom1
IPR018328, Rad4_beta-hairpin_dom3
IPR042488, Rad4_BHD3_sf
PANTHERiPTHR12135, PTHR12135, 2 hits
PfamiView protein in Pfam
PF10403, BHD_1, 1 hit
PF10405, BHD_3, 1 hit
PF03835, Rad4, 1 hit
SMARTiView protein in SMART
SM01030, BHD_1, 1 hit
SM01031, BHD_2, 1 hit
SM01032, BHD_3, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ1ZXA6_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1ZXA6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 2, 2006
Last sequence update: May 2, 2006
Last modified: June 2, 2021
This is version 88 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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