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Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Pyropia yezoensis (Susabi-nori) (Porphyra yezoensis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
Gene namesi
Name:pdhA
Synonyms:odpA
Encoded oniPlastid; Chloroplast
OrganismiPyropia yezoensis (Susabi-nori) (Porphyra yezoensis)
Taxonomic identifieri2788 [NCBI]
Taxonomic lineageiEukaryotaRhodophytaBangiophyceaeBangialesBangiaceaePyropia

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002772531 – 346Pyruvate dehydrogenase E1 component subunit alphaAdd BLAST346

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ1XDM0
SMRiQ1XDM0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

InterProiView protein in InterPro
IPR001017 DH_E1
IPR017597 Pyrv_DH_E1_asu_subgrp-y
IPR029061 THDP-binding
PfamiView protein in Pfam
PF00676 E1_dh, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
TIGRFAMsiTIGR03182 PDH_E1_alph_y, 1 hit

Sequencei

Sequence statusi: Complete.

Q1XDM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYPKKVQLP LTNYNSTGLN LNKSNLLVLY EDMLLGRNFE DMCAQMYYKG
60 70 80 90 100
KMFGFVHLYN GQEAVSTGVI KLLNPTDYVC STYRDHVHAL SKGVPSKNVM
110 120 130 140 150
AELFGKETGC SKGRGGSMHI FSAPHNFLGG FAFIAEGIPV ATGAAFQSIY
160 170 180 190 200
RQQVLKETED LRVTACFFGD GTTNNGQFFE CLNMAVLWKL PIIFVVENNQ
210 220 230 240 250
WAIGMAHHRS SSIPEIHKKA EAFGLPGIEV DGMDVLAVRQ AAKQAVQRAR
260 270 280 290 300
QGDGPTLIEA LTYRFRGHSL ADPDELRSRQ EKEAWVARDP IKKLKKYILD
310 320 330 340
NEIANIGELN EIQNAVKTEL EQAVKFAISS PEPNMSELKR YLFADN
Length:346
Mass (Da):38,637
Last modified:May 2, 2006 - v1
Checksum:iF5562613F29D9496
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006715 Genomic DNA Translation: BAE92391.1
RefSeqiYP_536948.1, NC_007932.1

Genome annotation databases

GeneIDi3978893

Similar proteinsi

Entry informationi

Entry nameiODPA_PYRYE
AccessioniPrimary (citable) accession number: Q1XDM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 2, 2006
Last modified: July 5, 2017
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

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