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Entry version 101 (13 Feb 2019)
Sequence version 2 (14 Oct 2008)
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Protein

Leucine-rich repeat-containing protein 36

Gene

LRRC36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 36
Alternative name(s):
ROR gamma-binding protein 70
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRC36
Synonyms:RORBP70
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000159708.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25615 LRRC36

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q1X8D7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000159708

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671524

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LRRC36

Domain mapping of disease mutations (DMDM)

More...
DMDMi
209572645

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002758551 – 754Leucine-rich repeat-containing protein 36Add BLAST754

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q1X8D7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q1X8D7

PeptideAtlas

More...
PeptideAtlasi
Q1X8D7

PRoteomics IDEntifications database

More...
PRIDEi
Q1X8D7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61251
61252 [Q1X8D7-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q1X8D7-2 [Q1X8D7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q1X8D7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q1X8D7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000159708 Expressed in 107 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q1X8D7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q1X8D7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA055237
HPA058479

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120570, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q1X8D7, 3 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q1X8D7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q1X8D7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati51 – 72LRR 1Add BLAST22
Repeati73 – 94LRR 2Add BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini107 – 146LRRCTAdd BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili600 – 680Sequence analysisAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi728 – 731Poly-Ser4

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFK9 Eukaryota
ENOG411199W LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063884

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060294

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG081929

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q1X8D7

KEGG Orthology (KO)

More...
KOi
K16594

Identification of Orthologs from Complete Genome Data

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OMAi
NYDSHYS

Database of Orthologous Groups

More...
OrthoDBi
881430at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q1X8D7

TreeFam database of animal gene trees

More...
TreeFami
TF338646

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q1X8D7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEQWELDEE GIRRLGALTL EQPELVESLS LQGSYAGKIH SIGDAFRNFK
60 70 80 90 100
NLRSLDLSRN LITSLKGIQY LCSLQDLNLY YNNIPSLVEV SRLQPLPFLK
110 120 130 140 150
ELDLRLNPVV RKDTDYRLFA VYTLQTLEKL DDRTVREGER KAAKLHFSQL
160 170 180 190 200
GNSENFLLEV EKSSREKTMK NCVTGESSAS KVSANVDSRI EMDSNKGLFI
210 220 230 240 250
PFPNREIKDS LSTSATQGNG TRDQKLDTFP LGTQTQEVAR REMPSDNHQE
260 270 280 290 300
DEFRHYSPRQ STVRSPEKMT REGYQVSFLD NKSSGSSPEK ELIPKPDTFH
310 320 330 340 350
LTHDASLSKC LDVGDSSQIH PYQLPSDVGL ENYDSCYSQT LSLHGSLGKR
360 370 380 390 400
PQRSKNYQEY SIKPSNDIKT TASHSCGDLL TSLSNPDSST GRLLKLSSDL
410 420 430 440 450
YATTHFNSDP AVLVNVEQQL STSLDDLTPA HGSVPNNAVL GNRTTPLRTL
460 470 480 490 500
LLSPGTSEHR KIFTKRSLSP SKRGFKWKDN ILANLNLKHG FQDATGSEPL
510 520 530 540 550
SSDLGSLHGL AGNHSPPISA RTPHVATVLR QLLELVDKHW NGSGSLLLNK
560 570 580 590 600
KFLGPARDLL LSLVVPAPSQ PRCCSHPEDT MKAFCRRELE LKEAAQLVPN
610 620 630 640 650
DMESLKQKLV RVLEENLILS EKIQQLEEGA AISIVSGQQS HTYDDLLHKN
660 670 680 690 700
QQLTMQVACL NQELAQLKKL EKTVAILHES QRSLVVTNEY LLQQLNKEPK
710 720 730 740 750
GYSGKALLPP EKGHHLGRSS PFGKSTLSSS SPVAHETGQY LIQSVLDAAP

EPGL
Length:754
Mass (Da):83,823
Last modified:October 14, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE7AD1F4151F340D2
GO
Isoform 2 (identifier: Q1X8D7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: Missing.
     122-130: YTLQTLEKL → MLRPRFLPP

Show »
Length:633
Mass (Da):69,950
Checksum:i595A48C0FF2CE1A4
GO
Isoform 3 (identifier: Q1X8D7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MAEQWELDE → MLRPRFLPP
     10-130: Missing.
     499-602: Missing.

Note: No experimental confirmation available.
Show »
Length:529
Mass (Da):58,658
Checksum:i86F6852A5B69AC7E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QSG3J3QSG3_HUMAN
Leucine-rich repeat-containing prot...
LRRC36
275Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRB2H3BRB2_HUMAN
Leucine-rich repeat-containing prot...
LRRC36
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNV0H3BNV0_HUMAN
Leucine-rich repeat-containing prot...
LRRC36
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQI9H3BQI9_HUMAN
Leucine-rich repeat-containing prot...
LRRC36
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRP7H3BRP7_HUMAN
Leucine-rich repeat-containing prot...
LRRC36
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BND7H3BND7_HUMAN
Leucine-rich repeat-containing prot...
LRRC36
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSQ6H3BSQ6_HUMAN
Leucine-rich repeat-containing prot...
LRRC36
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRT0J3QRT0_HUMAN
Leucine-rich repeat-containing prot...
LRRC36
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BS33H3BS33_HUMAN
Leucine-rich repeat-containing prot...
LRRC36
22Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti43G → S in AAY46032 (Ref. 2) Curated1
Sequence conflicti43G → S in AAH26156 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047015222R → P. Corresponds to variant dbSNP:rs9922085Ensembl.1
Natural variantiVAR_047016509G → S. Corresponds to variant dbSNP:rs8052655Ensembl.1
Natural variantiVAR_047017744S → G. Corresponds to variant dbSNP:rs16957415Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0229631 – 121Missing in isoform 2. 2 PublicationsAdd BLAST121
Alternative sequenceiVSP_0572641 – 9MAEQWELDE → MLRPRFLPP in isoform 3. 1 Publication9
Alternative sequenceiVSP_05726510 – 130Missing in isoform 3. 1 PublicationAdd BLAST121
Alternative sequenceiVSP_022964122 – 130YTLQTLEKL → MLRPRFLPP in isoform 2. 2 Publications9
Alternative sequenceiVSP_057266499 – 602Missing in isoform 3. 1 PublicationAdd BLAST104

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY313780 mRNA Translation: AAP81011.1
AY963267 mRNA Translation: AAY46032.1
AK292311 mRNA Translation: BAF85000.1
AK301766 mRNA Translation: BAH13549.1
AC009061 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW83126.1
BC026156 mRNA Translation: AAH26156.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32467.1 [Q1X8D7-1]
CCDS58474.1 [Q1X8D7-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001155047.1, NM_001161575.1 [Q1X8D7-2]
NP_060766.5, NM_018296.5 [Q1X8D7-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.125139

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000329956; ENSP00000329943; ENSG00000159708 [Q1X8D7-1]
ENST00000435835; ENSP00000411122; ENSG00000159708 [Q1X8D7-3]
ENST00000563189; ENSP00000455103; ENSG00000159708 [Q1X8D7-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55282

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55282

UCSC genome browser

More...
UCSCi
uc002esv.4 human [Q1X8D7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY313780 mRNA Translation: AAP81011.1
AY963267 mRNA Translation: AAY46032.1
AK292311 mRNA Translation: BAF85000.1
AK301766 mRNA Translation: BAH13549.1
AC009061 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW83126.1
BC026156 mRNA Translation: AAH26156.2
CCDSiCCDS32467.1 [Q1X8D7-1]
CCDS58474.1 [Q1X8D7-2]
RefSeqiNP_001155047.1, NM_001161575.1 [Q1X8D7-2]
NP_060766.5, NM_018296.5 [Q1X8D7-1]
UniGeneiHs.125139

3D structure databases

ProteinModelPortaliQ1X8D7
SMRiQ1X8D7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120570, 10 interactors
IntActiQ1X8D7, 3 interactors

PTM databases

iPTMnetiQ1X8D7
PhosphoSitePlusiQ1X8D7

Polymorphism and mutation databases

BioMutaiLRRC36
DMDMi209572645

Proteomic databases

jPOSTiQ1X8D7
PaxDbiQ1X8D7
PeptideAtlasiQ1X8D7
PRIDEiQ1X8D7
ProteomicsDBi61251
61252 [Q1X8D7-2]
TopDownProteomicsiQ1X8D7-2 [Q1X8D7-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329956; ENSP00000329943; ENSG00000159708 [Q1X8D7-1]
ENST00000435835; ENSP00000411122; ENSG00000159708 [Q1X8D7-3]
ENST00000563189; ENSP00000455103; ENSG00000159708 [Q1X8D7-2]
GeneIDi55282
KEGGihsa:55282
UCSCiuc002esv.4 human [Q1X8D7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55282
EuPathDBiHostDB:ENSG00000159708.17

GeneCards: human genes, protein and diseases

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GeneCardsi
LRRC36
HGNCiHGNC:25615 LRRC36
HPAiHPA055237
HPA058479
neXtProtiNX_Q1X8D7
OpenTargetsiENSG00000159708
PharmGKBiPA142671524

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IFK9 Eukaryota
ENOG411199W LUCA
GeneTreeiENSGT00530000063884
HOGENOMiHOG000060294
HOVERGENiHBG081929
InParanoidiQ1X8D7
KOiK16594
OMAiNYDSHYS
OrthoDBi881430at2759
PhylomeDBiQ1X8D7
TreeFamiTF338646

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55282

Protein Ontology

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PROi
PR:Q1X8D7

Gene expression databases

BgeeiENSG00000159708 Expressed in 107 organ(s), highest expression level in right testis
ExpressionAtlasiQ1X8D7 baseline and differential
GenevisibleiQ1X8D7 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
PROSITEiView protein in PROSITE
PS51450 LRR, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRC36_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1X8D7
Secondary accession number(s): A4FTV6
, A6NDE9, A8K8E6, B7Z7B3, Q7Z5K5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 14, 2008
Last modified: February 13, 2019
This is version 101 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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