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Protein

Alanine racemase

Gene

alr

Organism
Lactobacillus salivarius (strain UCC118)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei40Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei138SubstrateUniRule annotation1
Active sitei267Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei314Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr
Ordered Locus Names:LSL_0358
OrganismiLactobacillus salivarius (strain UCC118)
Taxonomic identifieri362948 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000006559 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000660031 – 371Alanine racemaseAdd BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ1WV14

Interactioni

Protein-protein interaction databases

STRINGi362948.LSL_0358

Structurei

3D structure databases

ProteinModelPortaliQ1WV14
SMRiQ1WV14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OMAiWEILCGF
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q1WV14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIGRHRNTR AIISLEAIKH NVATQISKLK DGQSLFAVVK ANAYGHGMIP
60 70 80 90 100
VAKAAKEAGA NGFCVAIIDE GIALRESGIK DPILILGVNP ASEAVCMAKH
110 120 130 140 150
DLSVAVGTLE FLTEAQKLLQ EEKQRLKIHL ALDTGMGRIG FRNTEDLKEA
160 170 180 190 200
VDFIEKHSDQ LKCEGVFTHF STADSKDPAY FEKQSQKFDE LVGVLKKKPK
210 220 230 240 250
YIHQANSATA LWHPNFEGNL VRMGISMYGL NPSGDMIDET WNLEPALSLE
260 270 280 290 300
SELVAVKEVE AGSSIGYGAT YTSSQSEWIG TVPIGYADGW LRRMQGFKVL
310 320 330 340 350
IDGQYCEIVG RVCMDQFMVR LPKKYDLGTK VTLIGENNGK VITAQDVANY
360 370
ADTIHYEIMC NITERVPRIY K
Length:371
Mass (Da):40,971
Last modified:May 2, 2006 - v1
Checksum:i5020FCC4DCB332EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000233 Genomic DNA Translation: ABD99171.1
RefSeqiWP_011475712.1, NC_007929.1
YP_535254.1, NC_007929.1

Genome annotation databases

EnsemblBacteriaiABD99171; ABD99171; LSL_0358
GeneIDi3977954
KEGGilsl:LSL_0358
PATRICifig|362948.14.peg.434

Similar proteinsi

Entry informationi

Entry nameiALR_LACS1
AccessioniPrimary (citable) accession number: Q1WV14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 2, 2006
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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