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Protein

Cell adhesion molecule 3

Gene

Cadm3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium

Enzyme and pathway databases

ReactomeiR-RNO-418990 Adherens junctions interactions
R-RNO-420597 Nectin/Necl trans heterodimerization

Names & Taxonomyi

Protein namesi
Recommended name:
Cell adhesion molecule 3
Alternative name(s):
Immunoglobulin superfamily member 4B
Short name:
IgSF4B
Nectin-like protein 1
Short name:
NECL-1
Gene namesi
Name:Cadm3
Synonyms:Igsf4b, Necl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1307035 Cadm3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 328ExtracellularSequence analysisAdd BLAST306
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Topological domaini350 – 396CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000024798923 – 396Cell adhesion molecule 3Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi48 ↔ 108PROSITE-ProRule annotation
Disulfide bondi150 ↔ 207PROSITE-ProRule annotation
Disulfide bondi252 ↔ 297PROSITE-ProRule annotation
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei386PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ1WIM3
PRIDEiQ1WIM3

PTM databases

iPTMnetiQ1WIM3
PhosphoSitePlusiQ1WIM3

Expressioni

Gene expression databases

BgeeiENSRNOG00000003365 Expressed in 10 organ(s), highest expression level in brain
ExpressionAtlasiQ1WIM3 baseline and differential
GenevisibleiQ1WIM3 RN

Interactioni

Subunit structurei

Homodimer. Can form trans-heterodimers with NECTIN3. Interacts with EPB41L1, DLG3, MPP6 and CASK (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi262276, 2 interactors
STRINGi10116.ENSRNOP00000004613

Structurei

3D structure databases

ProteinModelPortaliQ1WIM3
SMRiQ1WIM3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 124Ig-like V-typeAdd BLAST102
Domaini128 – 226Ig-like C2-type 1Add BLAST99
Domaini231 – 313Ig-like C2-type 2Add BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi322 – 325Poly-Ser4

Domaini

The cytoplasmic region mediates interaction with EPB41L1, DLG3, MPP6 and CASK.By similarity

Sequence similaritiesi

Belongs to the nectin family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFCE Eukaryota
ENOG411017U LUCA
GeneTreeiENSGT00900000140811
HOGENOMiHOG000036057
HOVERGENiHBG057086
InParanoidiQ1WIM3
KOiK06780
PhylomeDBiQ1WIM3
TreeFamiTF326804

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR003585 Neurexin-like
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF07679 I-set, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q1WIM3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAPSALPLL LLLACSWAPG GANLSQDDSQ PWTSDETVVA GGTVVLKCQV
60 70 80 90 100
KDHEDSSLQW SNPAQQTLYF GEKRALRDNR IQLVSSTPHE LSISISNVAL
110 120 130 140 150
ADEGEYTCSI FTMPVRTAKS LVTVLGIPQK PIITGYKSSL REKETATLNC
160 170 180 190 200
QSSGSKPAAQ LAWRKGDQEL HGDQTRIQED PNGKTFTVSS SVSFQVTRDD
210 220 230 240 250
DGANVVCSVN HESLKGADRS TSQRIEVLYT PTAMIRPEPA HPREGQKLLL
260 270 280 290 300
HCEGRGNPVP QQYVWVKEGS EPPLKMTQES ALIFPFLNKS DSGTYGCTAT
310 320 330 340 350
SNMGSYTAYF TLNVNDPSPV PSSSSTYHAI IGGIVAFIVF LLLILLIFLG
360 370 380 390
HYLIRHKGTY LTHEAKGSDD APDADTAIIN AEGGQSGGDD KKEYFI
Length:396
Mass (Da):42,906
Last modified:May 2, 2006 - v1
Checksum:i6F9C38384CD0E3BD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K872A0A0G2K872_RAT
Cell adhesion molecule 3
Cadm3
430Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ272743 mRNA Translation: ABB85362.1
RefSeqiNP_001040568.1, NM_001047103.1
UniGeneiRn.138884

Genome annotation databases

EnsembliENSRNOT00000004613; ENSRNOP00000004613; ENSRNOG00000003365
GeneIDi360882
KEGGirno:360882
UCSCiRGD:1307035 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ272743 mRNA Translation: ABB85362.1
RefSeqiNP_001040568.1, NM_001047103.1
UniGeneiRn.138884

3D structure databases

ProteinModelPortaliQ1WIM3
SMRiQ1WIM3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi262276, 2 interactors
STRINGi10116.ENSRNOP00000004613

PTM databases

iPTMnetiQ1WIM3
PhosphoSitePlusiQ1WIM3

Proteomic databases

PaxDbiQ1WIM3
PRIDEiQ1WIM3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004613; ENSRNOP00000004613; ENSRNOG00000003365
GeneIDi360882
KEGGirno:360882
UCSCiRGD:1307035 rat

Organism-specific databases

CTDi57863
RGDi1307035 Cadm3

Phylogenomic databases

eggNOGiENOG410IFCE Eukaryota
ENOG411017U LUCA
GeneTreeiENSGT00900000140811
HOGENOMiHOG000036057
HOVERGENiHBG057086
InParanoidiQ1WIM3
KOiK06780
PhylomeDBiQ1WIM3
TreeFamiTF326804

Enzyme and pathway databases

ReactomeiR-RNO-418990 Adherens junctions interactions
R-RNO-420597 Nectin/Necl trans heterodimerization

Miscellaneous databases

PROiPR:Q1WIM3

Gene expression databases

BgeeiENSRNOG00000003365 Expressed in 10 organ(s), highest expression level in brain
ExpressionAtlasiQ1WIM3 baseline and differential
GenevisibleiQ1WIM3 RN

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR003585 Neurexin-like
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF07679 I-set, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCADM3_RAT
AccessioniPrimary (citable) accession number: Q1WIM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: May 2, 2006
Last modified: September 12, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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