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Protein

Epithelial cell adhesion molecule

Gene

TACSTD1

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial cell adhesion molecule
Short name:
Ep-CAM
Alternative name(s):
Tumor-associated calcium signal transducer 1
CD_antigen: CD326
Gene namesi
Name:TACSTD1
Synonyms:EPCAM
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 265ExtracellularSequence analysisAdd BLAST242
Transmembranei266 – 288HelicalSequence analysisAdd BLAST23
Topological domaini289 – 314CytoplasmicSequence analysisAdd BLAST26

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000038018224 – 314Epithelial cell adhesion moleculeAdd BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 46PROSITE-ProRule annotation
Disulfide bondi29 ↔ 59PROSITE-ProRule annotation
Disulfide bondi38 ↔ 48PROSITE-ProRule annotation
Disulfide bondi66 ↔ 99PROSITE-ProRule annotation
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi110 ↔ 116PROSITE-ProRule annotation
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi118 ↔ 135PROSITE-ProRule annotation
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylation at Asn-198 is crucial for protein stability.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ1WER1

Expressioni

Gene expression databases

ExpressionAtlasiQ1WER1 baseline

Interactioni

Subunit structurei

Monomer. Interacts with phosphorylated CLDN7 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000016268

Structurei

3D structure databases

ProteinModelPortaliQ1WER1
SMRiQ1WER1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 135Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Belongs to the EPCAM family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFI6 Eukaryota
ENOG4111M3B LUCA
GeneTreeiENSGT00390000018245
HOGENOMiHOG000074086
InParanoidiQ1WER1
KOiK06737

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF00086 Thyroglobulin_1, 1 hit
SMARTiView protein in SMART
SM00211 TY, 1 hit
SUPFAMiSSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1WER1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPQVLAFG LLLAAATASF AAAQKECVCE NYKLAVNCFL NDNGQCQCTS
60 70 80 90 100
IGAQNTVLCS KLAAKCLVMK AEMNGSKLGR RAKPEGALQN NDGLYDPDCD
110 120 130 140 150
ESGLFKAKQC NGTSTCWCVN TAGVRRTDKD TEITCSERVR TYWIIIELKH
160 170 180 190 200
KAREKPYDVQ SLRTALEEAI KTRYQLDPKF ITNILYEDNV ITIDLVQNSS
210 220 230 240 250
QKTQNDVDIA DVAYYFEKDV KGESLFHSKK MDLRVNGEQL DLDPGQTLIY
260 270 280 290 300
YVDEKAPEFS MQGLKAGVIA VIVVVVIAIV AGIVVLVISR KKRMAKYEKA
310
EIKEMGEIHR ELNA
Length:314
Mass (Da):34,879
Last modified:May 2, 2006 - v1
Checksum:i2D5A7806F848A562
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ341470 mRNA Translation: ABC70159.1
RefSeqiNP_001035118.1, NM_001040029.1
UniGeneiMmu.3059

Genome annotation databases

EnsembliENSMMUT00000056802; ENSMMUP00000048687; ENSMMUG00000012390
GeneIDi677680
KEGGimcc:677680

Similar proteinsi

Entry informationi

Entry nameiEPCAM_MACMU
AccessioniPrimary (citable) accession number: Q1WER1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 2, 2006
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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