UniProtKB - Q1W617 (SHRM4_MOUSE)
Protein
Protein Shroom4
Gene
Shroom4
Organism
Mus musculus (Mouse)
Status
Functioni
Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II.1 Publication
GO - Molecular functioni
- actin filament binding Source: MGI
- myosin II binding Source: MGI
GO - Biological processi
- actin cytoskeleton organization Source: GO_Central
- actin filament organization Source: MGI
- brain development Source: MGI
- cognition Source: MGI
Keywordsi
Molecular function | Actin-binding, Developmental protein |
Names & Taxonomyi
Protein namesi | Recommended name: Protein Shroom4 |
Gene namesi | Name:Shroom4 Synonyms:Kiaa1202 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2685570 Shroom4 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Note: Shows partial colocalization with the cytoplasmic pool of F-actin.
Cytoskeleton
- actin filament Source: MGI
- cortical actin cytoskeleton Source: GO_Central
Plasma Membrane
- apical plasma membrane Source: MGI
- basal plasma membrane Source: MGI
- cytoplasmic side of plasma membrane Source: UniProtKB
Other locations
- adherens junction Source: GO_Central
- apical junction complex Source: GO_Central
- cytoplasm Source: MGI
- focal adhesion Source: MGI
- intracellular membrane-bounded organelle Source: MGI
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287078 | 1 – 1475 | Protein Shroom4Add BLAST | 1475 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 412 | PhosphoserineCombined sources | 1 | |
Modified residuei | 722 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1010 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q1W617 |
MaxQBi | Q1W617 |
PaxDbi | Q1W617 |
PeptideAtlasi | Q1W617 |
PRIDEi | Q1W617 |
PTM databases
iPTMneti | Q1W617 |
PhosphoSitePlusi | Q1W617 |
Expressioni
Tissue specificityi
Detected in most adult tissues examined. Expressed in brain, lung, heart, liver, kidney, muscle and ovary. Expressed throughout the brain, with high expression in the brain stem and cerebellum and weaker expression in the hypothalamus, the hippocampus and the olfactory bulb. Expressed in wide range of cell types during developpment, including vascular endothelium and the polarized epithelium of the neural tube and kidney.2 Publications
Developmental stagei
Slight expression at 8.5 dpc, increasing till 11.5 dpc and remaining continuous thereafter, suggesting regulated expression during development.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000068270 Expressed in 187 organ(s), highest expression level in placenta |
ExpressionAtlasi | Q1W617 baseline and differential |
Genevisiblei | Q1W617 MM |
Interactioni
Subunit structurei
Interacts directly with F-actin.
1 PublicationGO - Molecular functioni
- actin filament binding Source: MGI
- myosin II binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000100070 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 92 | PDZPROSITE-ProRule annotationAdd BLAST | 83 | |
Domaini | 1190 – 1469 | ASD2PROSITE-ProRule annotationAdd BLAST | 280 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1380 – 1470 | Sequence analysisAdd BLAST | 91 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 862 – 929 | Cys-richAdd BLAST | 68 | |
Compositional biasi | 1091 – 1098 | Poly-Pro | 8 | |
Compositional biasi | 1110 – 1187 | Gln-richAdd BLAST | 78 |
Sequence similaritiesi
Belongs to the shroom family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG410IERS Eukaryota ENOG41113GY LUCA |
GeneTreei | ENSGT00940000159479 |
HOGENOMi | HOG000060301 |
InParanoidi | Q1W617 |
KOi | K18625 |
OMAi | KPLHCSD |
OrthoDBi | 29607at2759 |
PhylomeDBi | Q1W617 |
TreeFami | TF333370 |
Family and domain databases
InterProi | View protein in InterPro IPR014799 ASD2_dom IPR001478 PDZ IPR036034 PDZ_sf IPR027687 Shroom4 IPR027685 Shroom_fam |
PANTHERi | PTHR15012 PTHR15012, 1 hit PTHR15012:SF35 PTHR15012:SF35, 1 hit |
Pfami | View protein in Pfam PF08687 ASD2, 1 hit PF00595 PDZ, 1 hit |
SMARTi | View protein in SMART SM00228 PDZ, 1 hit |
SUPFAMi | SSF50156 SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS51307 ASD2, 1 hit PS50106 PDZ, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q1W617-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MESRPGSFQY VPVQLQGGAP WGFTLKGGLE HCEPLTVSKI EDGGKAALSQ
60 70 80 90 100
KMRTGDELVN INGTPLYGSR QEALILIKGS FRILKLIVRR RNTPVSRPHS
110 120 130 140 150
WHVAKLLEGC PDVATTMHFP SEAFSLSWHS GCNTSDVSVQ WCPLSRHCST
160 170 180 190 200
EKSSSIGSME SLEQPGQPTY EGHLLPIDQN MYPSQRDSAY SSFSASSNAS
210 220 230 240 250
DCALSLKPEE PPSTDCVMPG PGPIKVTDDQ ANVSENSGSS HSTSEDHVTS
260 270 280 290 300
TSHASSYSDE GHHSGPAKMA RGPPEPPVRS DSLPASRAQL LNGEQHRASE
310 320 330 340 350
PVDSLPQKEK PGLETVLPPR SSNQFCCLSG QDQVTDEDHQ NCELSKPSES
360 370 380 390 400
SQDDCEHLLI EDSSKALDSP KAHDKGSNKE FGLLKEASAD LANTLNFGAI
410 420 430 440 450
PHLRGTMEHR HSAPEQLLAS HLQQVHLDSR GSKGMELPIG QDGHQWTVSP
460 470 480 490 500
LHNNPKGKKS PSLPTGGTQD QTRKERKTTP LDDKLMASVH QSQSDVLLGE
510 520 530 540 550
VDGHPNRAGR ASSDLTSQQP SATCSSVQQT RDFLSAHKIV DHTEASEEGD
560 570 580 590 600
NEPKECGRLG GRRSGGPRGR SIQNRRRSER FATNLRNEIQ RRKAQLQKSK
610 620 630 640 650
GPLSQLCDTN EAVEETQEPP ESPPLSASNA SLLPSYKNVP SPGDKVFNKS
660 670 680 690 700
MILRARSSEC LSQASESSKA RGGVEGRMSP GQRSGQSSLA LNTWWKASDS
710 720 730 740 750
STLDTEKANA HHGVCRGHWR WSPEHNAQPQ VALSTEAPSN PDDSKELKTS
760 770 780 790 800
TPQAGEEAVL MPFADRRKFF EESSKSLSTS HLPGLTTHNN KPFIQRQKPI
810 820 830 840 850
DQNFQSVSYR DLRCHPLDQS YHSADQSYHA ADQSYHSLSP LQSETPTYPE
860 870 880 890 900
CFATKGRDNS LCCKPVHHGD CDYHRTCSHP CSAQGTVRHD PCICCSGEIC
910 920 930 940 950
PALLKRNLLP KCHNCRCHHH QCIRCTGCCH GPQHSAHEDS SMAPGNAWKS
960 970 980 990 1000
RKAAIQEFPV DKWKPITGNR KTSHSGREMA HSKAGFSLST PFRPCIENPA
1010 1020 1030 1040 1050
LDLSNYRAVS SLDILGDFKR ASNKPEESSV YEDENSVASM PRPLRSRAFS
1060 1070 1080 1090 1100
ESHISLEPQN TQAWGKHQRE SFSKGSETQP DTLGARKKVF PPPRPPPPNW
1110 1120 1130 1140 1150
EKYRLFRAAQ LQQQQQQQQQ QQQQQRCEEE EEKEQEEEGE KEEDLPPQYF
1160 1170 1180 1190 1200
SSELTGSCAP NTEEQPQSLK MGHQEASRQG SQSLQEQEAF ALHPSNFVPP
1210 1220 1230 1240 1250
VRGCTVPQPE KAQHPCYYGT HGLWRTTEQE ATVTPKQEFQ HFSPPKGASG
1260 1270 1280 1290 1300
IPTSYSAYYN ISVAKAELLN KLKQQPEMAE AGLGEEGVDY ELAQKKIQLI
1310 1320 1330 1340 1350
ESISRKLSVL REAQRGLLDD INANAALGEE VEANLKAVCK SNEFEKYHLF
1360 1370 1380 1390 1400
IGDLDKVVNL LLSLSGRLAR VENALNSIDS ESNQEKLVLI EKKQQLTNQL
1410 1420 1430 1440 1450
ADAKELKEHV DGREKLVFGM VSRYLPQDQL QDYQHFVKMK SALIIEQREL
1460 1470
EEKIKLGEEQ LKCLKESLHL GPSNF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PUX3 | E9PUX3_MOUSE | Protein Shroom4 | Shroom4 | 200 | Annotation score: |
Sequence cautioni
The sequence BAD32407 differs from that shown. Reason: Erroneous initiation.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_025291 | 1 – 116 | Missing in isoform 2. 1 PublicationAdd BLAST | 116 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ435686 mRNA Translation: ABD98016.1 DQ435687 mRNA Translation: ABD98017.1 AK173129 mRNA Translation: BAD32407.1 Different initiation. AL671501 Genomic DNA No translation available. BC151022 mRNA Translation: AAI51023.1 |
CCDSi | CCDS29959.1 [Q1W617-1] CCDS85744.1 [Q1W617-2] |
RefSeqi | NP_001035549.1, NM_001040459.2 [Q1W617-1] NP_001300693.1, NM_001313764.1 NP_001300694.1, NM_001313765.1 [Q1W617-2] |
Genome annotation databases
Ensembli | ENSMUST00000089520; ENSMUSP00000086949; ENSMUSG00000068270 [Q1W617-2] ENSMUST00000103005; ENSMUSP00000100070; ENSMUSG00000068270 [Q1W617-1] |
GeneIDi | 208431 |
KEGGi | mmu:208431 |
UCSCi | uc009sky.1 mouse [Q1W617-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ435686 mRNA Translation: ABD98016.1 DQ435687 mRNA Translation: ABD98017.1 AK173129 mRNA Translation: BAD32407.1 Different initiation. AL671501 Genomic DNA No translation available. BC151022 mRNA Translation: AAI51023.1 |
CCDSi | CCDS29959.1 [Q1W617-1] CCDS85744.1 [Q1W617-2] |
RefSeqi | NP_001035549.1, NM_001040459.2 [Q1W617-1] NP_001300693.1, NM_001313764.1 NP_001300694.1, NM_001313765.1 [Q1W617-2] |
3D structure databases
SMRi | Q1W617 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000100070 |
PTM databases
iPTMneti | Q1W617 |
PhosphoSitePlusi | Q1W617 |
Proteomic databases
jPOSTi | Q1W617 |
MaxQBi | Q1W617 |
PaxDbi | Q1W617 |
PeptideAtlasi | Q1W617 |
PRIDEi | Q1W617 |
Genome annotation databases
Ensembli | ENSMUST00000089520; ENSMUSP00000086949; ENSMUSG00000068270 [Q1W617-2] ENSMUST00000103005; ENSMUSP00000100070; ENSMUSG00000068270 [Q1W617-1] |
GeneIDi | 208431 |
KEGGi | mmu:208431 |
UCSCi | uc009sky.1 mouse [Q1W617-1] |
Organism-specific databases
CTDi | 57477 |
MGIi | MGI:2685570 Shroom4 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | ENOG410IERS Eukaryota ENOG41113GY LUCA |
GeneTreei | ENSGT00940000159479 |
HOGENOMi | HOG000060301 |
InParanoidi | Q1W617 |
KOi | K18625 |
OMAi | KPLHCSD |
OrthoDBi | 29607at2759 |
PhylomeDBi | Q1W617 |
TreeFami | TF333370 |
Miscellaneous databases
ChiTaRSi | Shroom4 mouse |
PROi | PR:Q1W617 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000068270 Expressed in 187 organ(s), highest expression level in placenta |
ExpressionAtlasi | Q1W617 baseline and differential |
Genevisiblei | Q1W617 MM |
Family and domain databases
InterProi | View protein in InterPro IPR014799 ASD2_dom IPR001478 PDZ IPR036034 PDZ_sf IPR027687 Shroom4 IPR027685 Shroom_fam |
PANTHERi | PTHR15012 PTHR15012, 1 hit PTHR15012:SF35 PTHR15012:SF35, 1 hit |
Pfami | View protein in Pfam PF08687 ASD2, 1 hit PF00595 PDZ, 1 hit |
SMARTi | View protein in SMART SM00228 PDZ, 1 hit |
SUPFAMi | SSF50156 SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS51307 ASD2, 1 hit PS50106 PDZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SHRM4_MOUSE | |
Accessioni | Q1W617Primary (citable) accession number: Q1W617 Secondary accession number(s): A2ADV9, B2RX74, Q69ZN9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | May 2, 2006 | |
Last modified: | November 13, 2019 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot