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Entry version 111 (12 Aug 2020)
Sequence version 1 (16 May 2006)
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Protein

S-adenosylmethionine sensor upstream of mTORC1

Gene

BMT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes (PubMed:29123071). Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling (PubMed:29123071). Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling (PubMed:29123071). Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential).UniRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei172S-adenosyl-L-methionineUniRule annotation1 Publication1
Binding sitei190S-adenosyl-L-methionineUniRule annotation1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q1RMZ1

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-9639288, Amino acids regulate mTORC1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
S-adenosylmethionine sensor upstream of mTORC11 PublicationUniRule annotation
Alternative name(s):
Probable methyltransferase BMT2 homologUniRule annotation (EC:2.1.1.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BMT2UniRule annotationImported
Synonyms:C7orf60Imported, SAMTOR1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000164603.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26475, BMT2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617855, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q1RMZ1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000164603

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162380700

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q1RMZ1, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BMT2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121947576

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003215391 – 405S-adenosylmethionine sensor upstream of mTORC1Add BLAST405

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q1RMZ1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q1RMZ1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q1RMZ1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q1RMZ1

PeptideAtlas

More...
PeptideAtlasi
Q1RMZ1

PRoteomics IDEntifications database

More...
PRIDEi
Q1RMZ1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61242

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q1RMZ1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q1RMZ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q1RMZ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164603, Expressed in heart and 205 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q1RMZ1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q1RMZ1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000164603, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine (PubMed:29123071).

Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine (PubMed:29123071).

UniRule annotation1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127552, 20 interactors

Protein interaction database and analysis system

More...
IntActi
Q1RMZ1, 21 interactors

Molecular INTeraction database

More...
MINTi
Q1RMZ1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000297145

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q1RMZ1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q1RMZ1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BMT2 family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QRK4, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010382

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_036404_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q1RMZ1

KEGG Orthology (KO)

More...
KOi
K18849

Identification of Orthologs from Complete Genome Data

More...
OMAi
RSDMEDE

Database of Orthologous Groups

More...
OrthoDBi
836637at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q1RMZ1

TreeFam database of animal gene trees

More...
TreeFami
TF324724

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_03044, BMT2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021867, Bmt2/SAMTOR
IPR029063, SAM-dependent_MTases

The PANTHER Classification System

More...
PANTHERi
PTHR21008, PTHR21008, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11968, Bmt2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335, SSF53335, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q1RMZ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPGAGGRNT ARAQRAGSPN TPPPREQERK LEQEKLSGVV KSVHRRLRKK
60 70 80 90 100
YREVGDFDKI WREHCEDEET LCEYAVAMKN LADNHWAKTC EGEGRIEWCC
110 120 130 140 150
SVCREYFQNG GKRKALEKDE KRAVLATKTT PALNMHESSQ LEGHLTNLSF
160 170 180 190 200
TNPEFITELL QASGKIRLLD VGSCFNPFLK FEEFLTVGID IVPAVESVYK
210 220 230 240 250
CDFLNLQLQQ PLQLAQDAID AFLKQLKNPI DSLPGELFHV VVFSLLLSYF
260 270 280 290 300
PSPYQRWICC KKAHELLVLN GLLLIITPDS SHQNRHAMMM KSWKIAIESL
310 320 330 340 350
GFKRFKYSKF SHMHLMAFRK ISLKTTSDLV SRNYPGMLYI PQDFNSIEDE
360 370 380 390 400
EYSNPSCYVR SDIEDEQLAY GFTELPDAPY DSDSGESQAS SIPFYELEDP

ILLLS
Length:405
Mass (Da):46,324
Last modified:May 16, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5C19614953ABD670
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y6Y0H0Y6Y0_HUMAN
S-adenosylmethionine sensor upstrea...
BMT2
387Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB71169 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti219I → T in BAB71169 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK056380 mRNA Translation: BAB71169.1 Frameshift.
CH471070 Genomic DNA Translation: EAW83474.1
BC114615 mRNA Translation: AAI14616.1
AL834437 mRNA Translation: CAD39097.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43634.1

NCBI Reference Sequences

More...
RefSeqi
NP_689769.2, NM_152556.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000297145; ENSP00000297145; ENSG00000164603

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
154743

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:154743

UCSC genome browser

More...
UCSCi
uc003vgo.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056380 mRNA Translation: BAB71169.1 Frameshift.
CH471070 Genomic DNA Translation: EAW83474.1
BC114615 mRNA Translation: AAI14616.1
AL834437 mRNA Translation: CAD39097.1
CCDSiCCDS43634.1
RefSeqiNP_689769.2, NM_152556.2

3D structure databases

SMRiQ1RMZ1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127552, 20 interactors
IntActiQ1RMZ1, 21 interactors
MINTiQ1RMZ1
STRINGi9606.ENSP00000297145

PTM databases

iPTMnetiQ1RMZ1
PhosphoSitePlusiQ1RMZ1

Polymorphism and mutation databases

BioMutaiBMT2
DMDMi121947576

Proteomic databases

EPDiQ1RMZ1
jPOSTiQ1RMZ1
MassIVEiQ1RMZ1
PaxDbiQ1RMZ1
PeptideAtlasiQ1RMZ1
PRIDEiQ1RMZ1
ProteomicsDBi61242
TopDownProteomicsiQ1RMZ1

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
50763, 10 antibodies

Genome annotation databases

EnsembliENST00000297145; ENSP00000297145; ENSG00000164603
GeneIDi154743
KEGGihsa:154743
UCSCiuc003vgo.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
154743
EuPathDBiHostDB:ENSG00000164603.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BMT2
HGNCiHGNC:26475, BMT2
HPAiENSG00000164603, Low tissue specificity
MIMi617855, gene
neXtProtiNX_Q1RMZ1
OpenTargetsiENSG00000164603
PharmGKBiPA162380700

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QRK4, Eukaryota
GeneTreeiENSGT00390000010382
HOGENOMiCLU_036404_1_1_1
InParanoidiQ1RMZ1
KOiK18849
OMAiRSDMEDE
OrthoDBi836637at2759
PhylomeDBiQ1RMZ1
TreeFamiTF324724

Enzyme and pathway databases

PathwayCommonsiQ1RMZ1
ReactomeiR-HSA-9639288, Amino acids regulate mTORC1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
154743, 2 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BMT2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
154743
PharosiQ1RMZ1, Tdark

Protein Ontology

More...
PROi
PR:Q1RMZ1
RNActiQ1RMZ1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164603, Expressed in heart and 205 other tissues
ExpressionAtlasiQ1RMZ1, baseline and differential
GenevisibleiQ1RMZ1, HS

Family and domain databases

HAMAPiMF_03044, BMT2, 1 hit
InterProiView protein in InterPro
IPR021867, Bmt2/SAMTOR
IPR029063, SAM-dependent_MTases
PANTHERiPTHR21008, PTHR21008, 1 hit
PfamiView protein in Pfam
PF11968, Bmt2, 1 hit
SUPFAMiSSF53335, SSF53335, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSAMTR_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1RMZ1
Secondary accession number(s): Q8N3D0, Q96MV7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 16, 2006
Last modified: August 12, 2020
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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