UniProtKB - Q1RMI3 (GABP1_BOVIN)
Protein
GA-binding protein subunit beta-1
Gene
GABPB1
Organism
Bos taurus (Bovine)
Status
Functioni
Transcription factor capable of interacting with purine rich repeats (GA repeats). Acts as a a master regulator of nuclear-encoded mitochondrial genes.By similarity
GO - Molecular functioni
- transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- mitochondrion organization Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: GA-binding protein subunit beta-1Short name: GABP subunit beta-1 Short name: GABPB-1 Alternative name(s): GABP subunit beta-2 Short name: GABPB-2 |
Gene namesi | Name:GABPB1 Synonyms:GABPB2 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000318945 | 2 – 383 | GA-binding protein subunit beta-1Add BLAST | 382 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 69 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 340 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 369 | N6-acetyllysineBy similarity | 1 |
Post-translational modificationi
Acetylated by EP300/p300. Deacetylated by SIRT7, promoting heterotetramerization and activity.By similarity
Keywords - PTMi
AcetylationProteomic databases
PaxDbi | Q1RMI3 |
PRIDEi | Q1RMI3 |
Interactioni
Subunit structurei
Heterotetramer of two alpha and two beta subunits.
Interacts with HCFC1, causing repression of transcriptional activity.
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000030917 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 5 – 34 | ANK 1Add BLAST | 30 | |
Repeati | 37 – 66 | ANK 2Add BLAST | 30 | |
Repeati | 70 – 99 | ANK 3Add BLAST | 30 | |
Repeati | 103 – 132 | ANK 4Add BLAST | 30 | |
Repeati | 136 – 166 | ANK 5Add BLAST | 31 |
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | ENOG502QRTX, Eukaryota |
GeneTreei | ENSGT00940000157875 |
HOGENOMi | CLU_000134_12_1_1 |
InParanoidi | Q1RMI3 |
OrthoDBi | 1514706at2759 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 4 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q1RMI3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLVDLGKKL LEAARAGQDD EVRILMANGA PFTTDWLGTS PLHLAAQYGH
60 70 80 90 100
YSTTEVLLRA GVSRDARTKV DRTPLHMAAS EGHASIVEVL LKHGADVNAK
110 120 130 140 150
DMLKMTALHW ATEHNHQEVV ELLIKYGADV HTQSKFCKTA FDISIDNGNE
160 170 180 190 200
DLAEILQIAM QNQINTNPES PDTVTIHAAT PQFIIGPGGV VNLTDETGVS
210 220 230 240 250
AVQFGNSSTS VLATLAALAE ASAPLSNSSE TPVVATEEVV TAESVDGAIQ
260 270 280 290 300
QVVSSGGQQV ITIVTDGIQL GNLHSIPTSG IGQPIIVTMP DGQQVLTVPA
310 320 330 340 350
TDIAEETVIS EEPPAKRQCI EIIENRVESA EIEEREALQK QLDEANREAQ
360 370 380
KYRQQLLKKE QEAEAYRQKL EAMTRLQTNK EAV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG5E5T9 | G5E5T9_BOVIN | GA-binding protein subunit beta-1 | GABPB1 | 397 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC114881 mRNA Translation: AAI14882.1 |
RefSeqi | NP_001069272.1, NM_001075804.1 XP_003586626.3, XM_003586578.3 XP_015320604.1, XM_015465118.1 |
Genome annotation databases
Ensembli | ENSBTAT00000076865; ENSBTAP00000071985; ENSBTAG00000022801 |
GeneIDi | 520313 |
KEGGi | bta:520313 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC114881 mRNA Translation: AAI14882.1 |
RefSeqi | NP_001069272.1, NM_001075804.1 XP_003586626.3, XM_003586578.3 XP_015320604.1, XM_015465118.1 |
3D structure databases
SMRi | Q1RMI3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000030917 |
Proteomic databases
PaxDbi | Q1RMI3 |
PRIDEi | Q1RMI3 |
Genome annotation databases
Ensembli | ENSBTAT00000076865; ENSBTAP00000071985; ENSBTAG00000022801 |
GeneIDi | 520313 |
KEGGi | bta:520313 |
Organism-specific databases
CTDi | 2553 |
Phylogenomic databases
eggNOGi | ENOG502QRTX, Eukaryota |
GeneTreei | ENSGT00940000157875 |
HOGENOMi | CLU_000134_12_1_1 |
InParanoidi | Q1RMI3 |
OrthoDBi | 1514706at2759 |
Gene expression databases
ExpressionAtlasi | Q1RMI3, baseline and differential |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 4 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GABP1_BOVIN | |
Accessioni | Q1RMI3Primary (citable) accession number: Q1RMI3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | May 16, 2006 | |
Last modified: | December 2, 2020 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |