UniProtKB - Q1RLY5 (Q1RLY5_DANRE)
Protein
Tyrosine-protein kinase
Gene
lck
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Catalytic activityi
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]UniRule annotationARBA annotationEC:2.7.10.2UniRule annotationARBA annotation
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- non-membrane spanning protein tyrosine kinase activity Source: GO_Central
- signaling receptor binding Source: GO_Central
GO - Biological processi
- B cell receptor signaling pathway Source: GO_Central
- cell differentiation Source: GO_Central
- innate immune response Source: GO_Central
- peptidyl-tyrosine autophosphorylation Source: GO_Central
- regulation of cell population proliferation Source: GO_Central
- T cell differentiation Source: GO_Central
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Keywordsi
Molecular function | Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationARBA annotation |
Ligand | ATP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-DRE-1257604, PIP3 activates AKT signaling R-DRE-1433557, Signaling by SCF-KIT R-DRE-1433559, Regulation of KIT signaling R-DRE-210990, PECAM1 interactions R-DRE-2424491, DAP12 signaling R-DRE-389356, CD28 co-stimulation R-DRE-389357, CD28 dependent PI3K/Akt signaling R-DRE-389359, CD28 dependent Vav1 pathway R-DRE-389513, CTLA4 inhibitory signaling R-DRE-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
Names & Taxonomyi
Protein namesi | |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-040617-1, lck |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Lipid-anchor ARBA annotation; Cytoplasmic side ARBA annotation
Cytosol
- cytosol ARBA annotation
Other locations
- Membrane ARBA annotation; Lipid-anchor ARBA annotation; Cytoplasmic side ARBA annotation
Cytosol
- cytosol Source: UniProtKB-SubCell
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: GO_Central
PTM / Processingi
Keywords - PTMi
Lipoprotein, MyristateARBA annotation, PalmitateARBA annotation, PhosphoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSDARG00000102525, Expressed in head and 25 other tissues |
Interactioni
GO - Molecular functioni
- signaling receptor binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000096251 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 53 – 114 | SH3InterPro annotationAdd BLAST | 62 | |
Domaini | 120 – 217 | SH2InterPro annotationAdd BLAST | 98 | |
Domaini | 238 – 491 | Protein kinaseInterPro annotationAdd BLAST | 254 |
Sequence similaritiesi
Keywords - Domaini
SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000159864 |
HOGENOMi | CLU_000288_7_2_1 |
OMAi | ICEHCNY |
TreeFami | TF351634 |
Family and domain databases
CDDi | cd10362, SH2_Src_Lck, 1 hit cd12005, SH3_Lck, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR035850, Lck_SH2 IPR035749, Lck_SH3 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q1RLY5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGNCGSFDPD DEFSYHPDEW CDQCNCPKPP VSQNFDPLIP YPSQYTPPPS
60 70 80 90 100
SPLPENLVVA IYKYDPAHSD DLGFEKGEKM KILDCDDPEW YMAESLFTGQ
110 120 130 140 150
RGYIPKNFVA KLNSMETEPW FYKNLSRNDA MRQLLAPGNT QGSFLIRESE
160 170 180 190 200
TQPGSFSISV RDLDPMQGDI IKHYRIRNMD AGGFYITNKI SFNSLSELVK
210 220 230 240 250
HYSREADGLC TRLVKPCQTR APQKPWWQDE WEVPRESLKL ERRLGQGQFG
260 270 280 290 300
EVWMGLYNNN RQVAIKSLKP GTMSISAFLA EANLMKSLQH PRLVRLFAVV
310 320 330 340 350
TQEPIYIITE YMENGSLVDF LKTPEGSDIP INTLIDMAAQ VAEGMAYVEQ
360 370 380 390 400
KNYIHRDLRA ANILVSHELT CKIADFGLAR LIENNEYTAR EGAKFPIKWT
410 420 430 440 450
APEAINYGTF SIKSDVWSFG VLLTEIVTYG RIPYPGMTNP EVIANLERGY
460 470 480 490 500
RMPCPDNCPE ALYNVMKHCW TENPDNRPTF EFLRSVLEDF FTATEGQYQE
QPC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR392364 Genomic DNA No translation available. BC115230 mRNA Translation: AAI15231.1 BC162357 mRNA Translation: AAI62357.1 BC162378 mRNA Translation: AAI62378.1 |
RefSeqi | NP_001035418.1, NM_001040328.1 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR392364 Genomic DNA No translation available. BC115230 mRNA Translation: AAI15231.1 BC162357 mRNA Translation: AAI62357.1 BC162378 mRNA Translation: AAI62378.1 |
RefSeqi | NP_001035418.1, NM_001040328.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000096251 |
Genome annotation databases
Organism-specific databases
CTDi | 3932 |
ZFINi | ZDB-GENE-040617-1, lck |
Phylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000159864 |
HOGENOMi | CLU_000288_7_2_1 |
OMAi | ICEHCNY |
TreeFami | TF351634 |
Enzyme and pathway databases
Reactomei | R-DRE-1257604, PIP3 activates AKT signaling R-DRE-1433557, Signaling by SCF-KIT R-DRE-1433559, Regulation of KIT signaling R-DRE-210990, PECAM1 interactions R-DRE-2424491, DAP12 signaling R-DRE-389356, CD28 co-stimulation R-DRE-389357, CD28 dependent PI3K/Akt signaling R-DRE-389359, CD28 dependent Vav1 pathway R-DRE-389513, CTLA4 inhibitory signaling R-DRE-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
Gene expression databases
Bgeei | ENSDARG00000102525, Expressed in head and 25 other tissues |
Family and domain databases
CDDi | cd10362, SH2_Src_Lck, 1 hit cd12005, SH3_Lck, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR035850, Lck_SH2 IPR035749, Lck_SH3 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q1RLY5_DANRE | |
Accessioni | Q1RLY5Primary (citable) accession number: Q1RLY5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 16, 2006 |
Last sequence update: | May 16, 2006 | |
Last modified: | February 10, 2021 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |