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Protein
Submitted name:

Dihydrofolate reductase

Gene

folA

Organism
Escherichia coli (strain UTI89 / UPEC)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei50Substrate; via carbonyl oxygenUniRule annotation1
Binding sitei52NADP; via amide nitrogen and carbonyl oxygenUniRule annotationCombined sources1
Binding sitei59NADP; via carbonyl oxygenCombined sources1
Binding sitei64NADP; via amide nitrogen and carbonyl oxygenCombined sources1
Binding sitei72SubstrateUniRule annotation1
Binding sitei97SubstrateUniRule annotation1
Binding sitei102SubstrateUniRule annotation1
Binding sitei121NADP; via carbonyl oxygenUniRule annotation1
Binding sitei147NADPCombined sources1
Binding sitei158SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi58 – 64NADPUniRule annotation7
Nucleotide bindingi89 – 91NADPCombined sources3
Nucleotide bindingi90 – 91NADPUniRule annotation2
Nucleotide bindingi107 – 109NADPCombined sources3
Nucleotide bindingi108 – 109NADPUniRule annotation2
Nucleotide bindingi140 – 147NADPUniRule annotation8
Nucleotide bindingi141 – 143NADPCombined sources3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseImported
LigandNADPCombined sources, Nucleotide-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Dihydrofolate reductaseImported (EC:1.5.1.3Imported)
Gene namesi
Name:folAImported
Ordered Locus Names:UTI89_C0054Imported
OrganismiEscherichia coli (strain UTI89 / UPEC)Imported
Taxonomic identifieri364106 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000001952 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliQ1RGF0
SMRiQ1RGF0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ1RGF0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 203DHFRInterPro annotationAdd BLAST158

Sequence similaritiesi

Belongs to the dihydrofolate reductase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000040233
KOiK00287
OMAiRDNQLPW

Family and domain databases

CDDicd00209 DHFR, 1 hit
Gene3Di3.40.430.10, 2 hits
InterProiView protein in InterPro
IPR012259 DHFR
IPR024072 DHFR-like_dom_sf
IPR017925 DHFR_CS
IPR001796 DHFR_dom
PANTHERiPTHR22778:SF16 PTHR22778:SF16, 1 hit
PfamiView protein in Pfam
PF00186 DHFR_1, 1 hit
PIRSFiPIRSF000194 DHFR, 1 hit
SUPFAMiSSF53597 SSF53597, 1 hit
PROSITEiView protein in PROSITE
PS00075 DHFR_1, 1 hit
PS51330 DHFR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q1RGF0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRVQGESVD SPAEYKIFLN IILAPVDDGL RFTYSGDNFF YREISMISLI
60 70 80 90 100
AALAVDRVIG MENAMPWNLP ADLAWFKRNT LNKPVIMGRH TWESIGRPLP
110 120 130 140 150
GRKNIILSSQ PGTDDRVTWV KSVDEAIAAC GDVPEIMVIG GGRVYEQFLP
160 170 180 190 200
KAQKLYLTHI DAEVEGDTHF PDYEPDDWES VFSEFHDADA QNSHSYCFEI

LERR
Length:204
Mass (Da):23,212
Last modified:May 16, 2006 - v1
Checksum:i6385987DDF0954D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000243 Genomic DNA Translation: ABE05564.1

Genome annotation databases

EnsemblBacteriaiABE05564; ABE05564; UTI89_C0054
KEGGieci:UTI89_C0054

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000243 Genomic DNA Translation: ABE05564.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QL0X-ray1.60A46-68[»]
A70-204[»]
ProteinModelPortaliQ1RGF0
SMRiQ1RGF0
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE05564; ABE05564; UTI89_C0054
KEGGieci:UTI89_C0054

Phylogenomic databases

HOGENOMiHOG000040233
KOiK00287
OMAiRDNQLPW

Miscellaneous databases

EvolutionaryTraceiQ1RGF0

Family and domain databases

CDDicd00209 DHFR, 1 hit
Gene3Di3.40.430.10, 2 hits
InterProiView protein in InterPro
IPR012259 DHFR
IPR024072 DHFR-like_dom_sf
IPR017925 DHFR_CS
IPR001796 DHFR_dom
PANTHERiPTHR22778:SF16 PTHR22778:SF16, 1 hit
PfamiView protein in Pfam
PF00186 DHFR_1, 1 hit
PIRSFiPIRSF000194 DHFR, 1 hit
SUPFAMiSSF53597 SSF53597, 1 hit
PROSITEiView protein in PROSITE
PS00075 DHFR_1, 1 hit
PS51330 DHFR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ1RGF0_ECOUT
AccessioniPrimary (citable) accession number: Q1RGF0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2006
Last sequence update: May 16, 2006
Last modified: October 10, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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