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Protein

Peptidase E

Gene

pepE

Organism
Escherichia coli (strain UTI89 / UPEC)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.UniRule annotation

Catalytic activityi

Dipeptidase E catalyzes the hydrolysis of dipeptides Asp-|-Xaa. It does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei120Charge relay systemUniRule annotation1
Active sitei135Charge relay systemUniRule annotation1
Active sitei157Charge relay systemUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionDipeptidase, Hydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase EUniRule annotation (EC:3.4.13.21UniRule annotation)
Alternative name(s):
Alpha-aspartyl dipeptidaseUniRule annotation
Asp-specific dipeptidaseUniRule annotation
Dipeptidase EUniRule annotation
Gene namesi
Name:pepEUniRule annotation
Ordered Locus Names:UTI89_C4581
OrganismiEscherichia coli (strain UTI89 / UPEC)
Taxonomic identifieri364106 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000001952 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002585921 – 229Peptidase EAdd BLAST229

Structurei

3D structure databases

ProteinModelPortaliQ1R3S5
SMRiQ1R3S5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S51 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000281834
KOiK05995
OMAiKYTATVR

Family and domain databases

CDDicd03146 GAT1_Peptidase_E, 1 hit
Gene3Di3.40.50.880, 1 hit
HAMAPiMF_00510 Peptidase_E, 1 hit
InterProiView protein in InterPro
IPR029062 Class_I_gatase-like
IPR005320 Peptidase_S51
IPR023172 Peptidase_S51_dipeptidase-E
PfamiView protein in Pfam
PF03575 Peptidase_S51, 1 hit
SUPFAMiSSF52317 SSF52317, 1 hit

Sequencei

Sequence statusi: Complete.

Q1R3S5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELLLLSNST LPGKAWLEHA LPLIAEQLQG RRSAVFIPFA GVTQTWDDYT
60 70 80 90 100
AKTAAVLAPL GVSVTGIHSV VDPVAAIENA EIVIVGGGNT FQLLKQCRER
110 120 130 140 150
GLLAPITDVV KRGALYIGWS AGANLACPTI RTTNDMPIVD PQGFDALNLF
160 170 180 190 200
PLQINPHFTN ALPEGHKGET REQRIRELLV VAPELTIIGL PEGNWITVSK
210 220
GHATLGGPNT TYVFKAGEEA VPLEAGHRF
Length:229
Mass (Da):24,570
Last modified:May 16, 2006 - v1
Checksum:i53D4D8395DFC63FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000243 Genomic DNA Translation: ABE09989.1
RefSeqiWP_000421763.1, NC_007946.1

Genome annotation databases

EnsemblBacteriaiABE09989; ABE09989; UTI89_C4581
KEGGieci:UTI89_C4581

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000243 Genomic DNA Translation: ABE09989.1
RefSeqiWP_000421763.1, NC_007946.1

3D structure databases

ProteinModelPortaliQ1R3S5
SMRiQ1R3S5
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE09989; ABE09989; UTI89_C4581
KEGGieci:UTI89_C4581

Phylogenomic databases

HOGENOMiHOG000281834
KOiK05995
OMAiKYTATVR

Family and domain databases

CDDicd03146 GAT1_Peptidase_E, 1 hit
Gene3Di3.40.50.880, 1 hit
HAMAPiMF_00510 Peptidase_E, 1 hit
InterProiView protein in InterPro
IPR029062 Class_I_gatase-like
IPR005320 Peptidase_S51
IPR023172 Peptidase_S51_dipeptidase-E
PfamiView protein in Pfam
PF03575 Peptidase_S51, 1 hit
SUPFAMiSSF52317 SSF52317, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPEPE_ECOUT
AccessioniPrimary (citable) accession number: Q1R3S5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 16, 2006
Last modified: October 10, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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