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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciCSAL290398:G1GJB-1296-MONOMER
UniPathwayi
UPA00035;UER00042

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation (EC:5.3.1.24UniRule annotation)
Short name:
PRAIUniRule annotation
Gene namesi
Name:trpFUniRule annotation
Ordered Locus Names:Csal_1260
OrganismiChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Taxonomic identifieri290398 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeChromohalobacter
Proteomesi
  • UP000000239 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001970921 – 211N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST211

Interactioni

Protein-protein interaction databases

STRINGi290398.Csal_1260

Structurei

3D structure databases

ProteinModelPortaliQ1QY43
SMRiQ1QY43
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZGB Bacteria
COG0135 LUCA
HOGENOMiHOG000161598
KOiK01817
OMAiFYAKSPR
OrthoDBiPOG091H01PA

Family and domain databases

CDDicd00405 PRAI, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00135 PRAI, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001240 PRAI
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00697 PRAI, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit

Sequencei

Sequence statusi: Complete.

Q1QY43-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSPMQRTRV KICGLTREED IDAAVAAGAD ALGFVLWPGS SRAIDEARLA
60 70 80 90 100
RLAARVPAFV TRVGLFVDQA DDEIRRYARH LDLVQLHGNE SPDDCARLDT
110 120 130 140 150
PWIKALRMRD GIDLHAEMSR YDAARGLLLD AYRPGVPGGT GETFDWSRIP
160 170 180 190 200
ANLAKPVILA GGLTADNVAE AIHRVRPYAV DVSGGVEAAK GLKDPARIRA
210
FLSQVSHTQA P
Length:211
Mass (Da):22,875
Last modified:May 16, 2006 - v1
Checksum:i6759426EAC473532
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000285 Genomic DNA Translation: ABE58615.1
RefSeqiWP_011506561.1, NC_007963.1

Genome annotation databases

EnsemblBacteriaiABE58615; ABE58615; Csal_1260
KEGGicsa:Csal_1260

Similar proteinsi

Entry informationi

Entry nameiTRPF_CHRSD
AccessioniPrimary (citable) accession number: Q1QY43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 16, 2006
Last modified: September 12, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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