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Protein

Indole-3-glycerol phosphate synthase

Gene

trpC

Organism
Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.UniRule annotationSAAS annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotationSAAS annotation, Lyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCSAL290398:G1GJB-2381-MONOMER
UniPathwayiUPA00035; UER00043

Names & Taxonomyi

Protein namesi
Recommended name:
Indole-3-glycerol phosphate synthaseUniRule annotationSAAS annotation (EC:4.1.1.48UniRule annotationSAAS annotation)
Short name:
IGPSUniRule annotation
Gene namesi
Name:trpCUniRule annotation
Ordered Locus Names:Csal_2319Imported
OrganismiChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)Imported
Taxonomic identifieri290398 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeChromohalobacter
Proteomesi
  • UP000000239 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi290398.Csal_2319

Structurei

3D structure databases

ProteinModelPortaliQ1QV39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 268IGPSInterPro annotationAdd BLAST256

Sequence similaritiesi

Belongs to the TrpC family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DK0 Bacteria
COG0134 LUCA
HOGENOMiHOG000230463
KOiK01609
OMAiRKDFMVD
OrthoDBiPOG091H02GI

Family and domain databases

CDDicd00331 IGPS, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00134_B IGPS_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR013798 Indole-3-glycerol_P_synth
IPR001468 Indole-3-GlycerolPSynthase_CS
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00218 IGPS, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
PROSITEiView protein in PROSITE
PS00614 IGPS, 1 hit

Sequencei

Sequence statusi: Complete.

Q1QV39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRAHDTGLP TILARILARK DVEIRERRAQ VSEAELLERA RHEAAPRGFV
60 70 80 90 100
AALDRRIAAG DPAVIAEVKK ASPSKGVIRE DFQPAEIARA YAEAGASCLS
110 120 130 140 150
VLTDADFFQG HERDLQAARA ACTLPVIRKD FIVDAYQVSE ARAIGADCIL
160 170 180 190 200
LIVAALDDAR LKALHQQAHE LGMDVLVEVH DAAELERAMA LDLTLVGINN
210 220 230 240 250
RDLRTFDTTL TTTFDLLSRI PPHVTVVTES GIHTRGDVEH MREHDVNAFL
260 270
VGEAFMREAD PGSALRRLFF
Length:270
Mass (Da):29,675
Last modified:May 16, 2006 - v1
Checksum:i287C0FE07012A714
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000285 Genomic DNA Translation: ABE59669.1
RefSeqiWP_011507615.1, NC_007963.1

Genome annotation databases

EnsemblBacteriaiABE59669; ABE59669; Csal_2319
KEGGicsa:Csal_2319

Similar proteinsi

Entry informationi

Entry nameiQ1QV39_CHRSD
AccessioniPrimary (citable) accession number: Q1QV39
Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2006
Last sequence update: May 16, 2006
Last modified: July 18, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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