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Protein

Anthranilate synthase component 1

Gene

trpE

Organism
Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.UniRule annotation

Catalytic activityi

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesisUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00035; UER00040

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate synthase component 1UniRule annotation (EC:4.1.3.27UniRule annotation)
Gene namesi
Name:trpEUniRule annotation
Ordered Locus Names:Csal_2323Imported
OrganismiChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)Imported
Taxonomic identifieri290398 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeChromohalobacter
Proteomesi
  • UP000000239 Componenti: Chromosome

Interactioni

Subunit structurei

Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).UniRule annotation

Protein-protein interaction databases

STRINGi290398.Csal_2323

Structurei

3D structure databases

ProteinModelPortaliQ1QV35
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 192Anth_synt_I_NInterPro annotationAdd BLAST144
Domaini246 – 499Chorismate_bindInterPro annotationAdd BLAST254

Sequence similaritiesi

Belongs to the anthranilate synthase component I family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CRQ Bacteria
COG0147 LUCA
HOGENOMiHOG000025142
KOiK01657
OMAiIAGTFKR
OrthoDBiPOG091H01VQ

Family and domain databases

Gene3Di3.60.120.10, 1 hit
InterProiView protein in InterPro
IPR005801 ADC_synthase
IPR019999 Anth_synth_I-like
IPR006805 Anth_synth_I_N
IPR005256 Anth_synth_I_PabB
IPR015890 Chorismate_C
PfamiView protein in Pfam
PF04715 Anth_synt_I_N, 1 hit
PF00425 Chorismate_bind, 1 hit
PRINTSiPR00095 ANTSNTHASEI
SUPFAMiSSF56322 SSF56322, 1 hit
TIGRFAMsiTIGR00564 trpE_most, 1 hit

Sequencei

Sequence statusi: Complete.

Q1QV35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSPTRPRDP LVTQPLTEGT QGMMTPERFA ELAQAGYNRI PMTREVLADL
60 70 80 90 100
DTPLSTYLKL ADAPWTFLLE SVQGGEKWGR YSIIGLPSRE RIEVRGHEVR
110 120 130 140 150
HIVNGEQAGV TEADDPLAWI EQFQARFKVP QLDEQPRFDG GLVGYFGHDT
160 170 180 190 200
IRYIEPRLRG VEKPDPIGVP DILLMVCDEL VVFDNLSGRL TLWTHADPEV
210 220 230 240 250
ADAYPHALER LEALEMQLRS ATLNTVSPGT GGPAVEEGHF TSGFTEAGFK
260 270 280 290 300
AAVEQIKEYV LAGDVMQCVP SQRMTIPYRA PPLDLYRALR SLNPSPYMFF
310 320 330 340 350
FNLGDHHVVG SSPEILTRLE EGNVTVRPIA GTRVRGHSEA EDQALEAELL
360 370 380 390 400
ADPKEIAEHL MLIDLGRNDV GRISETGTVE VTDNMAIERY SHVMHIVSNV
410 420 430 440 450
TGKLKPGMSA LDVLRATFPA GTLSGAPKFR ALQILDELEP VKRGVYGGAV
460 470 480 490 500
GYLSWHGNMD TAIAIRTAVI KDGQLHVQAG AGIVADSVPE QEWQETLNKG
510
RALFRAVAMA ERGLDNLS
Length:518
Mass (Da):57,012
Last modified:May 16, 2006 - v1
Checksum:i1D17AEE510C368D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000285 Genomic DNA Translation: ABE59673.1

Genome annotation databases

EnsemblBacteriaiABE59673; ABE59673; Csal_2323
KEGGicsa:Csal_2323

Similar proteinsi

Entry informationi

Entry nameiQ1QV35_CHRSD
AccessioniPrimary (citable) accession number: Q1QV35
Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2006
Last sequence update: May 16, 2006
Last modified: July 18, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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