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  1. 1
    "Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism."
    Senee V., Chelala C., Duchatelet S., Feng D., Blanc H., Cossec J.-C., Charon C., Nicolino M., Boileau P., Cavener D.R., Bougneres P., Taha D., Julier C.
    Nat. Genet. 38:682-687(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Category: Sequences.
    Source: UniProtKB/TrEMBL (unreviewed).

    This publication is cited by 11 and mapped to 4 other entries.

  2. 2
    "Molecular genetics of successful smoking cessation: convergent genome-wide association study results."
    Uhl G.R., Liu Q.R., Drgon T., Johnson C., Walther D., Rose J.E., David S.P., Niaura R., Lerman C.
    Arch. Gen. Psychiatry 65:683-693(2008) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech.
    Annotation: Clinical trial and genome-wide association study of gene-disease association gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator).
    Source: GeneRIF:169792.

    This publication is mapped to 532 other entries.

  3. 3
    Category: Function, Pathology & Biotech.
    Annotation: Associated with IMMUNE: type 1 diabetes. [GAD:597734]. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator). [GeneRIF:169792].
    Source: GAD:597734, GeneRIF:169792.

    This publication is mapped to 37 other entries.

  4. 4
    "Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes."
    Type 1 Diabetes Genetics Consortium
    Barrett J.C., Clayton D.G., Concannon P., Akolkar B., Cooper J.D., Erlich H.A., Julier C., Morahan G., Nerup J., Nierras C., Plagnol V., Pociot F., Schuilenburg H., Smyth D.J., Stevens H., Todd J.A., Walker N.M., Rich S.S.
    Zhang Q.
    Nat. Genet. 41:703-707(2009) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech.
    Annotation: Associated with IMMUNE: type 1 diabetes. [GAD:597733]. Observational study meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator). [GeneRIF:169792].
    Source: GAD:597733, GeneRIF:169792.

    This publication is mapped to 142 other entries.

  5. 5
    "New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk."
    DIAGRAM Consortium
    Dupuis J., Langenberg C., Prokopenko I., Saxena R., Soranzo N., Jackson A.U., Wheeler E., Glazer N.L., Bouatia-Naji N., Gloyn A.L., Lindgren C.M., Magi R., Morris A.P., Randall J., Johnson T., Elliott P., Rybin D., Thorleifsson G.
    Barroso I.
    Nat. Genet. 42:105-116(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech.
    Annotation: Associated with METABOLIC: fasting glucose-related traits. [GAD:600670, GAD:600673]. Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator). [GeneRIF:169792].
    Source: GAD:600670, GAD:600673, GeneRIF:169792.

    This publication is mapped to 115 other entries.

  6. 6
    "Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement."
    Uhl G.R., Drgon T., Johnson C., Walther D., David S.P., Aveyard P., Murphy M., Johnstone E.C., Munafo M.R.
    Pharmacogenomics 11:357-367(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Annotation: Associated with CHEMDEPENDENCY: smoking cessation.
    Source: GAD:600279.

    This publication is mapped to 646 other entries.

  7. 7
    "In silico replication of the genome-wide association results of the Type 1 Diabetes Genetics Consortium."
    Qu H.Q., Bradfield J.P., Li Q., Kim C., Frackelton E., Grant S.F., Hakonarson H., Polychronakos C.
    Hum. Mol. Genet. 19:2534-2538(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Annotation: Observational study and meta-analysis of gene-disease association. (HuGE Navigator).
    Source: GeneRIF:169792.

    This publication is mapped to 57 other entries.

  8. 8
    "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
    Rose J.E., Behm F.M., Drgon T., Johnson C., Uhl G.R.
    Mol. Med. 16:247-253(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator).
    Source: GeneRIF:169792.

    This publication is mapped to 11701 other entries.

  9. 9
    "Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people."
    Meta-Analysis of Glucose and Insulin-Related Trait Consortium (MAGIC)
    Boesgaard T.W., Grarup N., Jorgensen T., Borch-Johnsen K., Hansen T., Pedersen O.
    Diabetologia 53:1647-1655(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech, Sequences.
    Annotation: Observational study of gene-disease association. (HuGE Navigator).
    Source: GeneRIF:169792.

    This publication is mapped to 59 other entries.

  10. 10
    Category: Pathology & Biotech, Sequences.
    Annotation: Children and adolescents carrying glucose-raising alleles of G6PC2 MTNR1B GCK and GLIS3 also showed reduced beta-cell function as indicated by homeostasis model assessment of beta-cell function.
    Source: GeneRIF:169792.

    This publication is mapped to 20 other entries.

  11. 11
    "Modulation of the transactivation function and stability of Kruppel-like zinc finger protein Gli-similar 3 (Glis3) by Suppressor of Fused."
    ZeRuth G.T., Yang X.P., Jetten A.M.
    J. Biol. Chem. 286:22077-22089(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: Glis3 interacts with Suppressor of Fused (SUFU).
    Source: GeneRIF:169792.

    This publication is mapped to 25 other entries.

  12. 12
    "Variants in GLIS3 and CRY2 are associated with type 2 diabetes and impaired fasting glucose in Chinese Hans."
    Liu C., Li H., Qi L., Loos R.J., Qi Q., Lu L., Gan W., Lin X.
    PLoS ONE 6:e21464-e21464(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: the associations of GLIS3-rs7034200 and CRY2-rs11605924 with fasting glucose beta cell function and type 2 diabetes.
    Source: GeneRIF:169792.

    This publication is mapped to 21 other entries.

  13. 13
    "Effects of 16 genetic variants on fasting glucose and type 2 diabetes in South Asians: ADCY5 and GLIS3 variants may predispose to type 2 diabetes."
    Rees S.D., Hydrie M.Z., O'Hare J.P., Kumar S., Shera A.S., Basit A., Barnett A.H., Kelly M.A.
    PLoS ONE 6:e24710-e24710(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech, Sequences.
    Annotation: Alleles of single nucleotide polymorphisms in GLIS3 and ADCY5 may confer risk of type 2 diabetes.
    Source: GeneRIF:169792.

    This publication is mapped to 23 other entries.

  14. 14
    "GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim."
    Nogueira T.C., Paula F.M., Villate O., Colli M.L., Moura R.F., Cunha D.A., Marselli L., Marchetti P., Cnop M., Julier C., Eizirik D.L.
    PLoS Genet. 9:e1003532-e1003532(2013) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: The present data suggest that altered expression of the candidate gene GLIS3 may contribute to both type 1 and 2 type diabetes by favouring beta cell apoptosis.
    Source: GeneRIF:169792.

    This publication is mapped to 22 other entries.

  15. 15
    Category: Sequences.
    Annotation: analysis of a GLIS3 variant that may have a role in resistance to Japanese type 1 diabetes.
    Source: GeneRIF:169792.

    This publication is mapped to 16 other entries.

  16. 16
    Category: Sequences.
    Annotation: Whole exome sequencing followed by immunohistochemistry of fibrolamellar hepatocellular carcinoma cell lines and tumors showed two structural variants resulting in fusion transcripts: DNAJB1-PRKCA and CLPTM1L-GLIS3.
    Source: GeneRIF:169792.

    This publication is mapped to 30 other entries.

  17. 17
    "HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity."
    ZeRuth G.T., Williams J.G., Cole Y.C., Jetten A.M.
    PLoS ONE 10:e0131303-e0131303(2015) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: It may play a role in a number of physiological processes controlled by Glis3.
    Source: GeneRIF:169792.

    This publication is mapped to 78 other entries.

  18. 18
    Category: Pathology & Biotech, Sequences.
    Annotation: New findings with GLIS3 phenotype including craniosynostosis hiatus hernia atrial septal defect splenic cyst and choanal atresia and confirm further cases with sensorineural deafness and exocrine pancreatic insufficiency.
    Source: GeneRIF:169792.

    This publication is mapped to 16 other entries.

  19. 19
    "An emerging, recognizable facial phenotype in association with mutations in GLI-similar 3 (GLIS3)."
    Dimitri P., De Franco E., Habeb A.M., Gurbuz F., Moussa K., Taha D., Wales J.K., Hogue J., Slavotinek A., Shetty A., Balasubramanian M.
    Am. J. Med. Genet. A 170:1918-1923(2016) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: we describe the common facial dysmorphism consisting of bilateral low-set ears depressed nasal bridge with overhanging columella elongated upslanted palpebral fissures persistent long philtrum with a thin vermilion border of the upper lip in a cohort of seven patients with GLIS3 mutations and report the emergence of a distinct probably recognizable facial gestalt in this group which evolves with age.
    Source: GeneRIF:169792.

    This publication is mapped to 16 other entries.

  20. 20
    "Assessing variation across 8 established East Asian loci for type 2 diabetes mellitus in American Indians: Suggestive evidence for new sex-specific diabetes signals in GLIS3 and ZFAND3."
    Muller Y.L., Piaggi P., Chen P., Wiessner G., Okani C., Kobes S., Knowler W.C., Bogardus C., Hanson R.L., Baier L.J.
    Diabetes Metab. Res. Rev. 33:0-0(2017) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech, Sequences.
    Annotation: Replication of lead type 2 diabetes mellitus SNPs in GLIS3 KCNK16 and ZFAND3 was observed in American Indians. Sex-specific T2DM signals in GLIS3 and ZFAND3 which are distinct from the East Asian GWAS signals were also identified.
    Source: GeneRIF:169792.

    This publication is mapped to 19 other entries.

  21. 21
    "GLIS3 rs7020673 and rs10758593 polymorphisms interact in the susceptibility for type 1 diabetes mellitus."
    Duarte G.C.K., Assmann T.S., Dieter C., de Souza B.M., Crispim D.
    Acta Diabetol 54:813-821(2017) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech, Sequences.
    Annotation: Individually the rs7020673 and rs10758593 SNPs are not significantly associated with T1DM but seem to interact in the predisposition for this disease.
    Source: GeneRIF:169792.

    This publication is mapped to 16 other entries.

  22. 22
    "The role of GLIS3 in thyroid disease as part of a multisystem disorder."
    Dimitri P.
    Best Pract. Res. Clin. Endocrinol. Metab. 31:175-182(2017) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: Given the role of GLIS3 in transcriptional activation and repression during embryogenesis in humans GLIS3 mutations present with multisystem involvement that also includes renal cystic dysplasia progressive liver fibrosis and osteopenia. Thyroid findings in GLIS3 patients include thyroid aplasia diminished colloid with interstitial fibrosis at post-mortem.(review).
    Source: GeneRIF:169792.

    This publication is mapped to 16 other entries.

  23. 23
    "GLIS3 and TYK2 Single Nucleotide Polymorphisms Are Not Associated with Dermatomyositis/Polymyositis in Chinese Han Population."
    Li L., Chen S., Wang Q., Wu C., Wen X., Yang F., Liu C., Zhang F., Li Y.
    Genet Test Mol Biomarkers 21:565-570(2017) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech, Sequences.
    Annotation: GLIS3 polymorphism is not associated with Dermatomyositis /Polymyositis in the Chinese Han population.
    Source: GeneRIF:169792.

    This publication is mapped to 20 other entries.

  24. 24
    Category: Function.
    Annotation: We detect a genome-wide significant association at rs10116772 with knee and/or hip total joint replacement; for allele A an intronic variant in GLIS3 which is expressed in cartilage of osteoarthritis patients.
    Source: GeneRIF:169792.

    This publication is mapped to 16 other entries.

  25. 25
    Category: Function, Interaction.
    Annotation: Data show that loss of zinc finger protein GLIS3 (GLIS3) causes beta-cell death.
    Source: GeneRIF:169792.

    This publication is mapped to 16 other entries.

1 to 25 of 26  Show
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