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Protein

Cyclin-SDS

Gene

SDS

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Meiosis-specific cyclin. Required for normal homolog synapsis and recombination in early to mid-prophase 1. May regulate the timing of sister chromatid separation.1 Publication

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • chiasma assembly Source: TAIR
  • double-strand break repair via homologous recombination Source: TAIR

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Meiosis

Enzyme and pathway databases

ReactomeiR-ATH-1538133 G0 and Early G1
R-ATH-5687128 MAPK6/MAPK4 signaling
R-ATH-69017 CDK-mediated phosphorylation and removal of Cdc6
R-ATH-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
R-ATH-69202 Cyclin E associated events during G1/S transition
R-ATH-69229 Ubiquitin-dependent degradation of Cyclin D1

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-SDS
Alternative name(s):
Protein SOLO DANCERS
Gene namesi
Name:SDS
Ordered Locus Names:At1g14750
ORF Names:F10B6.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G14750
TAIRilocus:2006827 AT1G14750

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Disruption phenotypei

Plants exhibit a severe defect in homolog synapsis recombination and bivalent formation in prophase 1, resulting in random chromosome distribution and formation of abnormal meiotic products.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002870621 – 578Cyclin-SDSAdd BLAST578

Proteomic databases

PaxDbiQ1PFW3
PRIDEiQ1PFW3

Expressioni

Developmental stagei

Expressed during male meiosis specifically in male meiotic cells (male meiocytes within anther locules). Expressed during female meiosis specifically in the female meiocytes within the ovule.1 Publication

Gene expression databases

ExpressionAtlasiQ1PFW3 baseline and differential
GenevisibleiQ1PFW3 AT

Interactioni

Subunit structurei

May interact with CDKA-1 AND CDKB1-1.

Protein-protein interaction databases

IntActiQ1PFW3, 2 interactors
STRINGi3702.AT1G14750.1

Structurei

3D structure databases

ProteinModelPortaliQ1PFW3
SMRiQ1PFW3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

eggNOGiKOG0653 Eukaryota
COG5024 LUCA
HOGENOMiHOG000070837
InParanoidiQ1PFW3
KOiK21777
OMAiQRLQMVH
OrthoDBiEOG093608N7
PhylomeDBiQ1PFW3

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q1PFW3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKEIAMRNSK RKPEPTPFAG KKLRSTRLRR KRAQISPVLV QSPLWSKQIG
60 70 80 90 100
VSAASVDSCS DLLADDNVSC GSSRVEKSSN PKKTLIEEVE VSKPGYNVKE
110 120 130 140 150
TIGDSKFRRI TRSYSKLHKE KEGDEIEVSE SSCVDSNSGA GLRRLNVKGN
160 170 180 190 200
KINDNDEISF SRSDVTFAGH VSNSRSLNFE SENKESDVVS VISGVEYCSK
210 220 230 240 250
FGSVTGGADN EEIEISKPSS FVEADSSLGS AKELKPELEI VGCVSDLACS
260 270 280 290 300
EKFSEEVSDS LDDESSEQRS EIYSQYSDFD YSDYTPSIFF DSGSEFSEKS
310 320 330 340 350
SSDSPISHSR SLYLQFKEQF CRSTIPNDFG SSCEEEIHSE LLRFDDEEVE
360 370 380 390 400
ESYLRLRERE RSHAYMRDCA KAYCSRMDNT GLIPRLRSIM VQWIVKQCSD
410 420 430 440 450
MGLQQETLFL GVGLLDRFLS KGSFKSERTL ILVGIASLTL ATRIEENQPY
460 470 480 490 500
NSIRKRNFTI QNLRYSRHEV VAMEWLVQEV LNFKCFTPTI FNFLWFYLKA
510 520 530 540 550
ARANPEVERK AKSLAVTSLS DQTQLCFWPS TVAAALVVLA CIEHNKISAY
560 570
QRVIKVHVRT TDNELPECVK SLDWLLGQ
Length:578
Mass (Da):65,201
Last modified:May 15, 2007 - v2
Checksum:i545EA75BD084DADD
GO
Isoform 2 (identifier: Q1PFW3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-257: Missing.

Note: No experimental confirmation available.
Show »
Length:410
Mass (Da):46,988
Checksum:iB4346CEB29578149
GO

Sequence cautioni

The sequence AAF79244 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02528990 – 257Missing in isoform 2. 1 PublicationAdd BLAST168

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ457977 mRNA Translation: CAD30003.1
AC006917 Genomic DNA Translation: AAF79244.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE29217.1
CP002684 Genomic DNA Translation: AEE29218.1
DQ446250 mRNA Translation: ABE65620.1
RefSeqiNP_001077539.1, NM_001084070.2 [Q1PFW3-2]
NP_172928.2, NM_101344.3 [Q1PFW3-1]
UniGeneiAt.41955

Genome annotation databases

EnsemblPlantsiAT1G14750.1; AT1G14750.1; AT1G14750 [Q1PFW3-1]
AT1G14750.2; AT1G14750.2; AT1G14750 [Q1PFW3-2]
GeneIDi838040
GrameneiAT1G14750.1; AT1G14750.1; AT1G14750 [Q1PFW3-1]
AT1G14750.2; AT1G14750.2; AT1G14750 [Q1PFW3-2]
KEGGiath:AT1G14750

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCCSDS_ARATH
AccessioniPrimary (citable) accession number: Q1PFW3
Secondary accession number(s): Q8RYC7, Q9LQV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: July 18, 2018
This is version 87 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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