UniProtKB - Q1PE48 (CDS3_ARATH)
Protein
Phosphatidate cytidylyltransferase 3
Gene
CDS3
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
May be involved in the synthesis of minor phospholipids and in modulation of IP3-mediated signal transduction.1 Publication
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H+ = a CDP-1,2-diacyl-sn-glycerol + diphosphate1 PublicationEC:2.7.7.411 Publication
Cofactori
Mg2+By similarityNote: Requires a divalent cation for activity.By similarity
: CDP-diacylglycerol biosynthesis Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.1 PublicationProteins known to be involved in the 3 steps of the subpathway in this organism are:
- Probable glycerol-3-phosphate acyltransferase 2 (GPAT2), Probable glycerol-3-phosphate acyltransferase 3 (GPAT3), Glycerol-3-phosphate acyltransferase, chloroplastic (C24_LOCUS3178), Glycerol-3-phosphate acyltransferase 7 (GPAT7), Glycerol-3-phosphate acyltransferase, chloroplastic (ATS1), Probable glycerol-3-phosphate acyltransferase 8 (GPAT8), Glycerol-3-phosphate acyltransferase 1 (GPAT1), Glycerol-3-phosphate acyltransferase 5 (GPAT5), Glycerol-3-phosphate acyltransferase, chloroplastic (AXX17_At1g32940)
- 1-acylglycerol-3-phosphate O-acyltransferase (AN1_LOCUS13297), 1-acyl-sn-glycerol-3-phosphate acyltransferase 3 (LPAT3), 1-acylglycerol-3-phosphate O-acyltransferase (AXX17_At1g69410), 1-acylglycerol-3-phosphate O-acyltransferase (AN1_LOCUS16143), 1-acylglycerol-3-phosphate O-acyltransferase, 1-acylglycerol-3-phosphate O-acyltransferase (LPAT5), 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 (LPAT2), DNA-directed RNA polymerase subunit (At3g57650), 1-acylglycerol-3-phosphate O-acyltransferase (LPAT5), 1-acylglycerol-3-phosphate O-acyltransferase (AN1_LOCUS6543), 1-acyl-sn-glycerol-3-phosphate acyltransferase LPAT1, chloroplastic (LPAT1), Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase 5 (LPAT5), 1-acylglycerol-3-phosphate O-acyltransferase (AXX17_At3g20050), Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase 4 (LPAT4), 1-acylglycerol-3-phosphate O-acyltransferase (C24_LOCUS13131), 1-acylglycerol-3-phosphate O-acyltransferase (C24_LOCUS16026), 1-acylglycerol-3-phosphate O-acyltransferase (AXX17_At1g45450), 1-acylglycerol-3-phosphate O-acyltransferase (C24_LOCUS4117)
- CDP-diacylglycerol synthase (F1P2.180), Phosphatidate cytidylyltransferase 1 (CDS1), Phosphatidate cytidylyltransferase (AN1_LOCUS5239), Phosphatidate cytidylyltransferase (C24_LOCUS18856), Phosphatidate cytidylyltransferase 3 (CDS3), Phosphatidate cytidylyltransferase (AXX17_At1g55730), Phosphatidate cytidylyltransferase (AXX17_At3g55010), Phosphatidate cytidylyltransferase 4, chloroplastic (CDS4), Phosphatidate cytidylyltransferase 2 (CDS2), Phosphatidate cytidylyltransferase (AXX17_At4g25970), Phosphatidate cytidylyltransferase (AXX17_At2g42720), CDP-diacylglycerol synthase (AN1_LOCUS15099), Phosphatidate cytidylyltransferase 5, chloroplastic (CDS5), Phosphatidate cytidylyltransferase (AN1_LOCUS18959), Phosphatidate cytidylyltransferase (AXX17_At4g30920), Phosphatidate cytidylyltransferase (CDS2), CDP-diacylglycerol synthase (At3g47630), CDP-diacylglycerol synthase (C24_LOCUS14979), Phosphatidate cytidylyltransferase (C24_LOCUS5115), CDP-diacylglycerol synthase (At3g47630), Phosphatidate cytidylyltransferase (CDS2), CDP-diacylglycerol synthase (AXX17_At3g41620), CDP-diacylglycerol synthase (At3g47630)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.
GO - Molecular functioni
- phosphatidate cytidylyltransferase activity Source: TAIR
GO - Biological processi
- CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Nucleotidyltransferase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Ligand | Magnesium |
Enzyme and pathway databases
UniPathwayi | UPA00557;UER00614 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidate cytidylyltransferase 31 Publication (EC:2.7.7.411 Publication)Alternative name(s): CDP-DAG synthase 3 CDP-DG synthase 3 CDP-diacylglycerol synthase 3 Short name: CDS3 CDP-diglyceride pyrophosphorylase 3 CDP-diglyceride synthase 3 CTP:phosphatidate cytidylyltransferase 3 |
Gene namesi | Name:CDS31 Publication Ordered Locus Names:At4g26770Imported ORF Names:F10M23.110Imported |
Organismi | Arabidopsis thaliana (Mouse-ear cress)Imported |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT4G26770 |
TAIRi | locus:2116272, AT4G26770 |
Subcellular locationi
Other locations
- Membrane Sequence analysis; Multi-pass membrane protein Sequence analysis
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 97 – 116 | Helical; Name=1Sequence analysisAdd BLAST | 20 | |
Transmembranei | 120 – 139 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Transmembranei | 149 – 169 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 196 – 216 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Transmembranei | 228 – 250 | Helical; Name=5Sequence analysisAdd BLAST | 23 | |
Transmembranei | 255 – 277 | Helical; Name=6Sequence analysisAdd BLAST | 23 | |
Transmembranei | 293 – 313 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Transmembranei | 368 – 388 | Helical; Name=8Sequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000431832 | 1 – 471 | Phosphatidate cytidylyltransferase 3Add BLAST | 471 |
Proteomic databases
PaxDbi | Q1PE48 |
PRIDEi | Q1PE48 |
ProteomicsDBi | 224389 |
PTM databases
iPTMneti | Q1PE48 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q1PE48, baseline and differential |
Genevisiblei | Q1PE48, AT |
Interactioni
Protein-protein interaction databases
IntActi | Q1PE48, 34 interactors |
STRINGi | 3702.AT4G26770.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the CDS family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1440, Eukaryota |
HOGENOMi | CLU_023471_2_0_1 |
InParanoidi | Q1PE48 |
OMAi | QLHIFNS |
OrthoDBi | 1072976at2759 |
PhylomeDBi | Q1PE48 |
Family and domain databases
InterProi | View protein in InterPro IPR000374, PC_trans IPR016720, PC_Trfase_euk |
PANTHERi | PTHR13773, PTHR13773, 1 hit |
PIRSFi | PIRSF018269, PC_trans_euk, 1 hit |
PROSITEi | View protein in PROSITE PS01315, CDS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q1PE48-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAMEKDLSPN SPRIRKLRDT SYPTTPTSRM NTNNQRDNHY PNIPNSPRDY
60 70 80 90 100
NYTPSSPTAR IRHRRRSSEN LAEVNRSNVS RVSNLLLGDK NKYRSMWIRT
110 120 130 140 150
CSSLWMLGGV VFIIYMGHLY IWAMVVVIQI FMAKELFFLR RRAHEERRLP
160 170 180 190 200
GFWLLNWHFF FTAMLFVYGR IIQQQLVNTV SSDRFIYKLV SGLIKYQMVI
210 220 230 240 250
CYFLYIAGLI WFILTLKNKM YKYQFGQYAW THMILIVVFT QSSFTVANIF
260 270 280 290 300
EGIFWFLLPA ALIAMNDVAA YFFGFYFGKT PLIKLSPKKT WEGFIGASVA
310 320 330 340 350
TIISAFIFAN VLGQFQWLTC PRKDLSTGWL HCDPGPLFRP EYYPFPSWIT
360 370 380 390 400
PFSPWKGIST LPVQWHAFSL GLFASIMAPF GGFFASGFKR AFKIKDFGDS
410 420 430 440 450
IPGHGGFTDR MDCQMVMAVF AYIYIQSFIV NRDYSVEMIL DQISRSLGHE
460 470
EQKMLYEKLG DILQHKLQGR F
Sequence cautioni
The sequence ABK28650 differs from that shown. Reason: Erroneous termination. Extended C-terminus.Curated
The sequence CAB36523 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB79532 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 325 | L → F in CAB36523 (PubMed:10617198).Curated | 1 | |
Sequence conflicti | 325 | L → F in CAB79532 (PubMed:10617198).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL035440 Genomic DNA Translation: CAB36523.1 Sequence problems. AL161565 Genomic DNA Translation: CAB79532.1 Sequence problems. CP002687 Genomic DNA Translation: AEE85250.1 DQ446870 mRNA Translation: ABE66091.1 DQ653225 mRNA Translation: ABK28650.1 Sequence problems. |
PIRi | T04800 |
RefSeqi | NP_194407.5, NM_118811.7 |
Genome annotation databases
EnsemblPlantsi | AT4G26770.1; AT4G26770.1; AT4G26770 |
GeneIDi | 828784 |
Gramenei | AT4G26770.1; AT4G26770.1; AT4G26770 |
KEGGi | ath:AT4G26770 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL035440 Genomic DNA Translation: CAB36523.1 Sequence problems. AL161565 Genomic DNA Translation: CAB79532.1 Sequence problems. CP002687 Genomic DNA Translation: AEE85250.1 DQ446870 mRNA Translation: ABE66091.1 DQ653225 mRNA Translation: ABK28650.1 Sequence problems. |
PIRi | T04800 |
RefSeqi | NP_194407.5, NM_118811.7 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q1PE48, 34 interactors |
STRINGi | 3702.AT4G26770.1 |
PTM databases
iPTMneti | Q1PE48 |
Proteomic databases
PaxDbi | Q1PE48 |
PRIDEi | Q1PE48 |
ProteomicsDBi | 224389 |
Genome annotation databases
EnsemblPlantsi | AT4G26770.1; AT4G26770.1; AT4G26770 |
GeneIDi | 828784 |
Gramenei | AT4G26770.1; AT4G26770.1; AT4G26770 |
KEGGi | ath:AT4G26770 |
Organism-specific databases
Araporti | AT4G26770 |
TAIRi | locus:2116272, AT4G26770 |
Phylogenomic databases
eggNOGi | KOG1440, Eukaryota |
HOGENOMi | CLU_023471_2_0_1 |
InParanoidi | Q1PE48 |
OMAi | QLHIFNS |
OrthoDBi | 1072976at2759 |
PhylomeDBi | Q1PE48 |
Enzyme and pathway databases
UniPathwayi | UPA00557;UER00614 |
Miscellaneous databases
PROi | PR:Q1PE48 |
Gene expression databases
ExpressionAtlasi | Q1PE48, baseline and differential |
Genevisiblei | Q1PE48, AT |
Family and domain databases
InterProi | View protein in InterPro IPR000374, PC_trans IPR016720, PC_Trfase_euk |
PANTHERi | PTHR13773, PTHR13773, 1 hit |
PIRSFi | PIRSF018269, PC_trans_euk, 1 hit |
PROSITEi | View protein in PROSITE PS01315, CDS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CDS3_ARATH | |
Accessioni | Q1PE48Primary (citable) accession number: Q1PE48 Secondary accession number(s): A0MF99, Q9SZ17 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 4, 2015 |
Last sequence update: | May 16, 2006 | |
Last modified: | December 2, 2020 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families