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UniProtKB - Q1PDH6 (LAC16_ARATH)
Protein
Laccase-16
Gene
LAC16
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Lignin degradation and detoxification of lignin-derived products.
By similarityCatalytic activityi
- EC:1.10.3.2
Cofactori
Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 84 | Copper 1; type 2By similarity | 1 | |
Metal bindingi | 86 | Copper 2; type 3By similarity | 1 | |
Metal bindingi | 129 | Copper 2; type 3By similarity | 1 | |
Metal bindingi | 131 | Copper 3; type 3By similarity | 1 | |
Metal bindingi | 467 | Copper 4; type 1By similarity | 1 | |
Metal bindingi | 470 | Copper 1; type 2By similarity | 1 | |
Metal bindingi | 472 | Copper 3; type 3By similarity | 1 | |
Metal bindingi | 529 | Copper 3; type 3By similarity | 1 | |
Metal bindingi | 530 | Copper 4; type 1By similarity | 1 | |
Metal bindingi | 531 | Copper 2; type 3By similarity | 1 | |
Metal bindingi | 535 | Copper 4; type 1By similarity | 1 |
GO - Molecular functioni
- copper ion binding Source: InterPro
- hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC
- oxidoreductase activity Source: GO_Central
GO - Biological processi
- lignin catabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Lignin degradation |
Ligand | Copper, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Laccase-16 (EC:1.10.3.2)Alternative name(s): Benzenediol:oxygen oxidoreductase 16 Diphenol oxidase 16 Urishiol oxidase 16 |
Gene namesi | Name:LAC16 Ordered Locus Names:At5g58910 ORF Names:K19M22.11 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT5G58910 |
TAIRi | locus:2154518, AT5G58910 |
Subcellular locationi
Extracellular region or secreted
- apoplast Curated
Extracellular region or secreted
- apoplast Source: UniProtKB-SubCell
Keywords - Cellular componenti
Apoplast, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_0000283644 | 28 – 566 | Laccase-16Add BLAST | 539 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 39 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 80 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 116 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 300 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 331 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 389 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 406 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 449 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q1PDH6 |
ProteomicsDBi | 237038 |
Expressioni
Tissue specificityi
Mostly expressed in roots at low level.2 Publications
Gene expression databases
ExpressionAtlasi | Q1PDH6, baseline and differential |
Genevisiblei | Q1PDH6, AT |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 37 – 150 | Plastocyanin-like 1Add BLAST | 114 | |
Domaini | 160 – 312 | Plastocyanin-like 2Add BLAST | 153 | |
Domaini | 414 – 550 | Plastocyanin-like 3Add BLAST | 137 |
Sequence similaritiesi
Belongs to the multicopper oxidase family.Curated
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | KOG1263, Eukaryota |
HOGENOMi | CLU_006504_6_3_1 |
InParanoidi | Q1PDH6 |
PhylomeDBi | Q1PDH6 |
Family and domain databases
CDDi | cd13849, CuRO_1_LCC_plant, 1 hit cd13875, CuRO_2_LCC_plant, 1 hit cd13897, CuRO_3_LCC_plant, 1 hit |
Gene3Di | 2.60.40.420, 3 hits |
InterProi | View protein in InterPro IPR001117, Cu-oxidase IPR011706, Cu-oxidase_C IPR045087, Cu-oxidase_fam IPR011707, Cu-oxidase_N IPR033138, Cu_oxidase_CS IPR002355, Cu_oxidase_Cu_BS IPR008972, Cupredoxin IPR034288, CuRO_1_LCC IPR034285, CuRO_2_LCC IPR034289, CuRO_3_LCC IPR017761, Laccase |
PANTHERi | PTHR11709, PTHR11709, 1 hit |
Pfami | View protein in Pfam PF00394, Cu-oxidase, 1 hit PF07731, Cu-oxidase_2, 1 hit PF07732, Cu-oxidase_3, 1 hit |
SUPFAMi | SSF49503, SSF49503, 3 hits |
TIGRFAMsi | TIGR03389, laccase, 1 hit |
PROSITEi | View protein in PROSITE PS00079, MULTICOPPER_OXIDASE1, 1 hit PS00080, MULTICOPPER_OXIDASE2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q1PDH6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEIPRRFCIC VLTFFVFVLL SPTTVHSIIR HYKFNVMTNT TKLCSSKPIV
60 70 80 90 100
TVNGQFPGPT IVAREGDTIL IKVVNHVKYN VSIHWHGIRQ LRTGWADGPA
110 120 130 140 150
YITQCPIQPG QNYLHNFTLT GQRGTLWWHA HILWLRATVH GAIVILPKLG
160 170 180 190 200
VPYPFPKPYK EKTIVLSEWW KSDVEELINE ASRIGTAPSA SDAHTINGHS
210 220 230 240 250
GSISNCPSQS SYGLPVRAGK TYMLRIINAA LNEELFFKIA GHVLTVVEVD
260 270 280 290 300
AVYTKPYKTD TVFIAPGQTT NVLLTANANA GSNYMVAATT FTDAHIPYDN
310 320 330 340 350
VTATATLHYI GHTSTVSTSK KTVLASLPPQ NATWVATKFT RSLRSLNSLE
360 370 380 390 400
YPARVPTTVE HSLFFTVGLG ANPCQSCNNG VRLVAGINNV TFTMPKTALL
410 420 430 440 450
QAHFFNISGV FTDDFPAKPS NPYDYTAPVK LGVNAATMKG TKLYRLPYNA
460 470 480 490 500
TVQIVLQNTA MILSDNHPFH LHGFNFFEVG RGLGNFNPEK DPKAFNLVDP
510 520 530 540 550
VERNTVGVPA GGWTAIRFIA DNPGVWFMHC HLELHTTWGL KMAFVVDNGH
560
GPDQSLLPPP ADLPKC
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1P8BAQ4 | A0A1P8BAQ4_ARATH | Laccase | LAC16 laccase 16, At5g58910, K19M22.11, K19M22_11 | 567 | Annotation score: |
Sequence cautioni
The sequence ABK28766 differs from that shown. Reason: Erroneous termination. Extended C-terminus.Curated
The sequence AED97116 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB016885 Genomic DNA No translation available. CP002688 Genomic DNA Translation: AED97116.1 Sequence problems. CP002688 Genomic DNA Translation: ANM68673.1 DQ447092 mRNA Translation: ABE66261.1 DQ653381 mRNA Translation: ABK28766.1 Sequence problems. |
RefSeqi | NP_001330401.1, NM_001345329.1 NP_200699.1, NM_125281.1 |
Genome annotation databases
EnsemblPlantsi | AT5G58910.3; AT5G58910.3; AT5G58910 |
GeneIDi | 836008 |
Gramenei | AT5G58910.3; AT5G58910.3; AT5G58910 |
KEGGi | ath:AT5G58910 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB016885 Genomic DNA No translation available. CP002688 Genomic DNA Translation: AED97116.1 Sequence problems. CP002688 Genomic DNA Translation: ANM68673.1 DQ447092 mRNA Translation: ABE66261.1 DQ653381 mRNA Translation: ABK28766.1 Sequence problems. |
RefSeqi | NP_001330401.1, NM_001345329.1 NP_200699.1, NM_125281.1 |
3D structure databases
AlphaFoldDBi | Q1PDH6 |
SMRi | Q1PDH6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 3702.AT5G58910.1 |
Proteomic databases
PaxDbi | Q1PDH6 |
ProteomicsDBi | 237038 |
Genome annotation databases
EnsemblPlantsi | AT5G58910.3; AT5G58910.3; AT5G58910 |
GeneIDi | 836008 |
Gramenei | AT5G58910.3; AT5G58910.3; AT5G58910 |
KEGGi | ath:AT5G58910 |
Organism-specific databases
Araporti | AT5G58910 |
TAIRi | locus:2154518, AT5G58910 |
Phylogenomic databases
eggNOGi | KOG1263, Eukaryota |
HOGENOMi | CLU_006504_6_3_1 |
InParanoidi | Q1PDH6 |
PhylomeDBi | Q1PDH6 |
Miscellaneous databases
PROi | PR:Q1PDH6 |
Gene expression databases
ExpressionAtlasi | Q1PDH6, baseline and differential |
Genevisiblei | Q1PDH6, AT |
Family and domain databases
CDDi | cd13849, CuRO_1_LCC_plant, 1 hit cd13875, CuRO_2_LCC_plant, 1 hit cd13897, CuRO_3_LCC_plant, 1 hit |
Gene3Di | 2.60.40.420, 3 hits |
InterProi | View protein in InterPro IPR001117, Cu-oxidase IPR011706, Cu-oxidase_C IPR045087, Cu-oxidase_fam IPR011707, Cu-oxidase_N IPR033138, Cu_oxidase_CS IPR002355, Cu_oxidase_Cu_BS IPR008972, Cupredoxin IPR034288, CuRO_1_LCC IPR034285, CuRO_2_LCC IPR034289, CuRO_3_LCC IPR017761, Laccase |
PANTHERi | PTHR11709, PTHR11709, 1 hit |
Pfami | View protein in Pfam PF00394, Cu-oxidase, 1 hit PF07731, Cu-oxidase_2, 1 hit PF07732, Cu-oxidase_3, 1 hit |
SUPFAMi | SSF49503, SSF49503, 3 hits |
TIGRFAMsi | TIGR03389, laccase, 1 hit |
PROSITEi | View protein in PROSITE PS00079, MULTICOPPER_OXIDASE1, 1 hit PS00080, MULTICOPPER_OXIDASE2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LAC16_ARATH | |
Accessioni | Q1PDH6Primary (citable) accession number: Q1PDH6 Secondary accession number(s): A0MFQ5, F4KGE3, Q3E893 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 3, 2007 |
Last sequence update: | April 3, 2007 | |
Last modified: | May 25, 2022 | |
This is version 103 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families