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UniProtKB - Q1PDC4 (L_MABVR)

Entry version 66 (18 Sep 2019)
Sequence version 1 (16 May 2006)
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Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain Kenya/Ravn/1987))
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymerase binds to the genomic RNA at the 3' leader promoter, and transcribes subsequently all viral mRNAs with a decreasing efficiency. The first gene is the most transcribed, and the last the least transcribed. The viral phosphoprotein acts as a processivity factor. Capping is concommitant with initiation of mRNA transcription. Indeed, a GDP polyribonucleotidyl transferase (PRNTase) adds the cap structure when the nascent RNA chain length has reached few nucleotides. Ribose 2'-O methylation of viral mRNA cap precedes and facilitates subsequent guanine-N-7 methylation, both activities being carried by the viral polymerase. Polyadenylation of mRNAs occur by a stuttering mechanism at a slipery stop site present at the end viral genes. After finishing transcription of a mRNA, the polymerase can resume transcription of the downstream gene.By similarity
RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Multifunctional enzyme, Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processmRNA capping, mRNA processing, Viral RNA replication
LigandATP-binding, Nucleotide-binding, S-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-directed RNA polymerase L
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Including the following 4 domains:
RNA-directed RNA polymerase (EC:2.7.7.48By similarity)
mRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.56By similarity)
GDP polyribonucleotidyltransferase (EC:2.7.7.88By similarity)
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC:2.1.1.296By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain Kenya/Ravn/1987))
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri378809 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Negarnaviricota › Haploviricotina › Monjiviricetes › Mononegavirales › Filoviridae › Marburgvirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiChlorocebus aethiops (Green monkey) (Cercopithecus aethiops) [TaxID: 9534]
Homo sapiens (Human) [TaxID: 9606]
Rousettus aegyptiacus (Egyptian rousette) (Egyptian fruit bat) [TaxID: 9407]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008239 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Host cytoplasm, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003149721 – 2327RNA-directed RNA polymerase LAdd BLAST2327

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q1PDC4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini628 – 812RdRp catalyticPROSITE-ProRule annotationAdd BLAST185
Domaini1921 – 2118Mononegavirus-type SAM-dependent 2'-O-MTasePROSITE-ProRule annotationAdd BLAST198

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039736 L_poly_C
IPR026890 Mononeg_mRNAcap
IPR014023 Mononeg_RNA_pol_cat
IPR025786 Mononega_L_MeTrfase
IPR017235 RNA-dir_pol_L_filovirus

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14318 Mononeg_mRNAcap, 1 hit
PF00946 Mononeg_RNA_pol, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037548 RNA_pol_Filoviridae, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR04198 paramyx_RNAcap, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50526 RDRP_SSRNA_NEG_NONSEG, 1 hit
PS51590 SAM_MT_MNV_L, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q1PDC4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQHPTQYPDA RLSSPIILDQ CDLLTRSLGL YSHYSHNPKL RNCRIPYHIY 
        60         70         80         90        100
RLRNSTALKT FLQNCSILTV PFHSIWDHII TSIQHDAINH INDFKYLLPS 
       110        120        130        140        150
ELIKYANWDN EFLRVFLNKI LRLDHAFTNS AKLQCEDFSP KENPYYWGML 
       160        170        180        190        200
LLVHLSQLAR RIKGQRGSLR SNWKFIGVDL ELFGIADFVI FKVPIKAIIR 
       210        220        230        240        250
NATSLQASKP GLKTWYRDQN LTPYLCDDEF VVSIASYECF IMIKDVFIER 
       260        270        280        290        300
YNTWEICARA WVEDNEEADY PPLGILRDLY NQGDQIITMY LEDGFKLIKH 
       310        320        330        340        350
LEPLCVSCIQ TYGIFTPRKY WFQSQMIKSY YDELQSLNLK LQIPDNRTEC 
       360        370        380        390        400
AQNFIKTIIQ AKLTPQQYCE LFSLQKHWGH PVLYNDVALD KVKKHAQSTK 
       410        420        430        440        450
ILKPKVMFET FCVFKFIVAK NHYHSQGSWY KTTHDLHLTP YLRQHIVSNS 
       460        470        480        490        500
FPSQAEIYQH LWEWYFVEHE PLFSTKIISD LSIFIKDRAT AVNRECWDSV 
       510        520        530        540        550
FDRSVLGYNP PVRFQSKRVP EQFLGQADFS LNQILDFAEK LEYLAPSYRN 
       560        570        580        590        600
FSFSLKEKEL NIGRTFGKLP YRVRNVQTLA EALLADGLAK AFPSNMMVVT 
       610        620        630        640        650
EREQKEALLH QASWHHNSAS IGENAIVRGA SFVTDLEKYN LAFRYEFTRH 
       660        670        680        690        700
FIDYCNRCYG VKNLFDWMHF LIPLCYMHVS DFYSPPHCVT ENNRNNPPDC 
       710        720        730        740        750
ANAYHYHLGG IEGLQQKLWT CISCAQITLV ELKTKLKLKS SVMGDNQCIT 
       760        770        780        790        800
TLSLFPIDAP NDYQENEAEL NAARVAVELA ITTGYSGIFL KPEETFVHSG 
       810        820        830        840        850
FIYFGKKQYL NGVQLPQSLK TMARCGPLSD SIFDDLQGSL ASIGTSFERG 
       860        870        880        890        900
ASETRHIFPS RWIAAFHSML AVNLLNQNHL GFPLGFSIDV SCFKKPLTFS 
       910        920        930        940        950
EKLIALITPQ VLGGLSFLNP EKLFYRNISD PLTSGLFQLR NALEFLRKEE 
       960        970        980        990       1000
LFYILIAKKP GLADASDFVM NPLGLNVPGS REIITFLRQT VRENITITSQ 
      1010       1020       1030       1040       1050
NRIINSLFHI GSDLEDQRVC EWLLSSNPVM SRFAADIFSR TPSGKRLQVL 
      1060       1070       1080       1090       1100
GYLEGTRTLL ASRTISLTTE GTMLMRLREL TKSRWKSWFS YIDALDDDLS 
      1110       1120       1130       1140       1150
ESLEKFICTV DVANFLRAYS WSDVLKGKRL IGATLPCLLE QFNVKWVNLS 
      1160       1170       1180       1190       1200
EDLKEQFKLS SDLGSPTDLL QYDCNGLHSK GADNAELNYV SCALDRKIVQ 
      1210       1220       1230       1240       1250
KHPSDNRLAW TIGNRAPYIG SRTEDKIGYP PLRVNCPSAA LKEAIEMVSR 
      1260       1270       1280       1290       1300
LLWVTQGTAD REKLLIPLLN SRVNLDYQTV LNFLPTHYSG NIVHRYNDQY 
      1310       1320       1330       1340       1350
GQHSFMANRM SNTSTRAIIS TNTLGKYAGG GQAAVDSNII FQNTINLGVA 
      1360       1370       1380       1390       1400
VLDITLSLSK LSSTSNVSFR LMLSKCCTRH VPSEYLFFDK PLDVDLNKYM 
      1410       1420       1430       1440       1450
DNELVYDNDP LCSGIKGRLG RVSRSTLSLS LNVSDIGSYD FPTIAAWTLG 
      1460       1470       1480       1490       1500
ETIIGSIFSD ESSQSTDPIS SGCTKTFVTH FLVYPVESIF YAFGANLIVE 
      1510       1520       1530       1540       1550
SLSLSRINSI KSLSDLTFLI SSTIRNLSHR SLRILQSTFR HELVLTRLAH 
      1560       1570       1580       1590       1600
HIPLISLMLG GSAGEKSSSD AVRLFLTASY QNFINNFSCL MRKNQSPLPV 
      1610       1620       1630       1640       1650
WLYFPSEGQQ LKPILKILQR LSCLLTTKKV QNHRPVADTC FLTDNFWVYP 
      1660       1670       1680       1690       1700
SKSTRTNHYY ASLNYWRDKA NKIKNTSFSH LINYSFSEPS LHASSISSSQ 
      1710       1720       1730       1740       1750
EVVNLKHTSR LDETPNMSER AQSTNHEPTA LQEVCTEIPY SEQDPAKSYL 
      1760       1770       1780       1790       1800
LLENTRFRDD QKILRHDQKA ERGEPLSLQV SSRGCLQALT CPHHPSPSQT 
      1810       1820       1830       1840       1850
TTEPLSMLRN CDAIKAALRS ETNDPRLMSS ILDMRSLKTP MRIESRNTSL 
      1860       1870       1880       1890       1900
LQPSECLSTS KGKSVLSREQ ASYLYVDCSN ISSISLDSGF RNMSDRNQVQ 
      1910       1920       1930       1940       1950
MLINTYKRDL YTCFDSNQFC RFTGVVSSMH YKLYDLLPAG KLGKAICLAE 
      1960       1970       1980       1990       2000
GEGSGARLLL KWKETDYLFF NTLATDSQQE AEILSGRVIP RMLYNIDKLS 
      2010       2020       2030       2040       2050
VLLESRKLIL NNLTIQITDI TNPLWLDSVI QYLPEDSDIL TMDAETTKEE 
      2060       2070       2080       2090       2100
TREQLYKTII NIWARTSPNI PKTSIIKVFL LDYGGTLFLM KNAIQYYGQV 
      2110       2120       2130       2140       2150
QLKKPYSSNA KNSEWYLCCG KRRVQRLRVD FPDQVGIFLI CKAMSRQRQA 
      2160       2170       2180       2190       2200
IPYWLKHIEK NYPASLHEFF ITLGFPSLES SFCHRYTIPF TEGTALFHKV 
      2210       2220       2230       2240       2250
QSYVRQGRQH LHSLMLDYEN NSPLLDLRNH FICSLRGKIT KYYNDILKLN 
      2260       2270       2280       2290       2300
LVVRAVERGK NWSQLVESLP NMHSVCITHV DHECIGCERR LLLKLDFVRN 
      2310       2320 
TKIAEQKLLN RVIGYILFFP FGFSRPK
Length:2,327
Mass (Da):266,524
Last modified:May 16, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3F4516E0D40608F1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
DQ447649 Genomic RNA Translation: ABE27074.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ447649 Genomic RNA Translation: ABE27074.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PRIDEiQ1PDC4

Family and domain databases

InterProiView protein in InterPro
IPR039736 L_poly_C
IPR026890 Mononeg_mRNAcap
IPR014023 Mononeg_RNA_pol_cat
IPR025786 Mononega_L_MeTrfase
IPR017235 RNA-dir_pol_L_filovirus
PfamiView protein in Pfam
PF14318 Mononeg_mRNAcap, 1 hit
PF00946 Mononeg_RNA_pol, 1 hit
PIRSFiPIRSF037548 RNA_pol_Filoviridae, 1 hit
TIGRFAMsiTIGR04198 paramyx_RNAcap, 1 hit
PROSITEiView protein in PROSITE
PS50526 RDRP_SSRNA_NEG_NONSEG, 1 hit
PS51590 SAM_MT_MNV_L, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL_MABVR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1PDC4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 16, 2006
Last modified: September 18, 2019
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome
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