INSC

Functionⁱ

May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex (PubMed:16458856).

Involved in spindle orientation during mitosis. May regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (By similarity).

By similarity1 Publication

GO - Molecular functionⁱ

cytoskeletal anchor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
protein domain specific binding
Source: UniProtKB
Inferred from physical interactionⁱ
- Ref.6
  "Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN)."
  Yuzawa S., Kamakura S., Iwakiri Y., Hayase J., Sumimoto H.
  Proc. Natl. Acad. Sci. U.S.A. 108:19210-19215(2011) [PubMed] [Europe PMC] [Abstract]
  Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 70-116 IN COMPLEX WITH GPSM2, INTERACTION WITH GPSM2 AND GPSM1, SUBCELLULAR LOCATION, MUTAGENESIS OF TRP-78; GLU-89 AND LYS-97.
protein-macromolecule adaptor activity
Source: UniProtKB
Inferred from physical interactionⁱ
- Ref.1
  "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3."
  Izaki T., Kamakura S., Kohjima M., Sumimoto H.
  Biochem. Biophys. Res. Commun. 341:1001-1006(2006) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH PARD3B; F2RL2; GPSM1 AND GPSM2.

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Differentiation, Neurogenesis

Enzyme and pathway databases

PathwayCommonsⁱ	Q1MX18
SignaLinkⁱ	Q1MX18

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein inscuteable homolog
Gene namesⁱ	Name:INSC
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:33116, INSC
MIMⁱ	610668, gene
neXtProtⁱ	NX_Q1MX18
VEuPathDBⁱ	HostDB:ENSG00000188487

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	78	W → A: Abolishes interaction with GPSM2. 1 Publication	1
Mutagenesisⁱ	89	E → R: Strongly reduces interaction with GPSM2. Abolishes interaction with GPSM2 and GPSM1; when associated with D-97. 1 Publication	1
Mutagenesisⁱ	97	K → D: Abolishes interaction with GPSM2 and GPSM1; when associated with R-89. 1 Publication	1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000188487
PharmGKBⁱ	PA162392191

Miscellaneous databases

Pharosⁱ	Q1MX18, Tbio

Pharosⁱ

Q1MX18, Tbio

Genetic variation databases

BioMutaⁱ	INSC
DMDMⁱ	116248172

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000252405	1 – 579	Protein inscuteable homologAdd BLAST		579

Proteomic databases

EPDⁱ	Q1MX18
MassIVEⁱ	Q1MX18
PaxDbⁱ	Q1MX18
PeptideAtlas More...PeptideAtlasⁱ	Q1MX18
PRIDEⁱ	Q1MX18
ProteomicsDBⁱ	61231 [Q1MX18-1] 61232 [Q1MX18-2] 61235 [Q1MX18-5] 69

PTM databases

iPTMnetⁱ	Q1MX18
PhosphoSitePlusⁱ	Q1MX18

Expressionⁱ

Tissue specificityⁱ

Isoform 1 is expressed in various tissues with stronger expression in liver, kidney and small intestine. Isoform 2 is abundantly expressed in small intestine and to a lower extent in lung and pancreas.2 Publications

Developmental stageⁱ

Expressed in fetal cochlea.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000188487, Expressed in tibia and 119 other tissues
ExpressionAtlasⁱ	Q1MX18, baseline and differential
Genevisibleⁱ	Q1MX18, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000188487, Tissue enriched (parathyroid)

HPAⁱ

ENSG00000188487, Tissue enriched (parathyroid)

Interactionⁱ

Subunit structureⁱ

Interacts with ALS2CR19/PAR3B and F2RL2/PAR3 (PubMed:16458856).

Interacts with GPSM1/AGS3 and GPSM2/LGN (via TPR repeat region) (PubMed:16458856, PubMed:22074847).

Identified in a complex with GPSM2 and F2RL2 (PubMed:16458856).

2 Publications

Binary interactionsⁱ

Hide details

Q1MX18

With	#Exp.	IntAct
GEM [P55040]	3	EBI-12081118,EBI-744104
GPANK1 [O95872]	3	EBI-12081118,EBI-751540
GPSM2 [P81274]	3	EBI-12081118,EBI-618655
LHX3 - isoform B [Q9UBR4-2]	3	EBI-12081118,EBI-12039345
MGC50722 [Q8IVT4]	3	EBI-12081118,EBI-14086479
PRR35 [P0CG20]	3	EBI-12081118,EBI-11986293
RUSC1 [Q9BVN2]	3	EBI-12081118,EBI-6257312
SMARCD1 [Q96GM5]	3	EBI-12081118,EBI-358489
SORBS3 [O60504]	3	EBI-12081118,EBI-741237
TEKT3 [Q9BXF9]	5	EBI-12081118,EBI-8644516
TTC23 - isoform 3 [Q5W5X9-3]	3	EBI-12081118,EBI-9090990
USP54 - isoform 6 [Q70EL1-9]	3	EBI-12081118,EBI-11975223
ZNF587 [Q96SQ5]	3	EBI-12081118,EBI-6427977

GO - Molecular functionⁱ

protein domain specific binding
Source: UniProtKB
Inferred from physical interactionⁱ
- Ref.6
  "Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN)."
  Yuzawa S., Kamakura S., Iwakiri Y., Hayase J., Sumimoto H.
  Proc. Natl. Acad. Sci. U.S.A. 108:19210-19215(2011) [PubMed] [Europe PMC] [Abstract]
  Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 70-116 IN COMPLEX WITH GPSM2, INTERACTION WITH GPSM2 AND GPSM1, SUBCELLULAR LOCATION, MUTAGENESIS OF TRP-78; GLU-89 AND LYS-97.

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	132426, 37 interactors
CORUMⁱ	Q1MX18
IntActⁱ	Q1MX18, 13 interactors
STRINGⁱ	9606.ENSP00000368872

Miscellaneous databases

RNActⁱ	Q1MX18, protein

RNActⁱ

Q1MX18, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	73 – 82	Combined sources	10
Beta strandⁱ	91 – 95	Combined sources	5
Helixⁱ	103 – 105	Combined sources	3
Beta strandⁱ	109 – 112	Combined sources	4

Show more details

3D structure databases

AlphaFoldDBⁱ	Q1MX18
SMRⁱ	Q1MX18
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	74 – 89	Important for interaction with GPSM21 PublicationAdd BLAST		16

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	576 – 579	PDZ-binding		4

Phylogenomic databases

eggNOGⁱ	ENOG502QRY2, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001511
InParanoidⁱ	Q1MX18
Database of Orthologous Groups More...OrthoDBⁱ	569133at2759
PhylomeDBⁱ	Q1MX18
TreeFamⁱ	TF323559

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit 6.20.200.10, 1 hit
IDEALⁱ	IID00323
InterProⁱ	View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000225, Armadillo IPR045789, Insc_C IPR031938, INSC_LBD IPR038205, INSC_LBD_sf IPR039921, Inscuteable
PANTHERⁱ	PTHR21386, PTHR21386, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF19427, Insc_C, 1 hit PF16748, INSC_LBD, 1 hit
SMARTⁱ	View protein in SMART SM00185, ARM, 3 hits
SUPFAMⁱ	SSF48371, SSF48371, 1 hit

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q1MX18-1) [UniParc]FASTA Add to basket

Also known as: Long

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRPPGNGEA ASEGPGGWGL WGVQESRRLC CAGHDRCKQA LLQIGINMMA 
        60         70         80         90        100
LPGGRHLDSV TLPGQRLHLM QVDSVQRWME DLKLMTECEC MCVLQAKPIS 
       110        120        130        140        150
LEEDAQGDLI LAGGPGPGDP LQLLLKRGWV ISTELRRIGQ KLAQDRWARV 
       160        170        180        190        200
HSMSVRLTCH ARSMVSEYSA VSRNSLKEMG EIEKLLMEKC SELSAVTERC 
       210        220        230        240        250
LQVENEHVLK SMKACVSETL SMLGQHFGQL LELALTREVQ ALVRKIDASD 
       260        270        280        290        300
NIYTTESTTG NLFSLTQEGA PLCRIIAKEG GVVALFKVCR QDSFRCLYPQ 
       310        320        330        340        350
ALRTLASICC VEEGVHQLEK VDGVLCLADI LTDNSHSEAT RAEAAAVVAQ 
       360        370        380        390        400
VTSPHLPVTQ HLSSFLESME EIVTALVKLC QEASSGEVFL LASAALANIT 
       410        420        430        440        450
FFDTMACEML LQLNAIRVLL EACSDKQRVD TPYTRDQIVT ILANMSVLEQ 
       460        470        480        490        500
CASDIIQENG VQLIMGMLSE KPRSGTPAEV AACERVQQKA AVTLARLSRD 
       510        520        530        540        550
PDVAREAVRL SCMSRLIELC RSPSERNSSD AVLVACLAAL RRLAGVCPEG 
       560        570 
LQDSDFQQLV QPRLVDSFLL CSNMEESFV

Length:579

Mass (Da):63,469

Last modified:May 30, 2006 - v1

Checksum:ⁱ7CD8D19409FC3266

GO

Isoform 2 (identifier: Q1MX18-2) [UniParc]FASTA Add to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
1-47: Missing.

« Hide

        10         20         30         40         50
MMALPGGRHL DSVTLPGQRL HLMQVDSVQR WMEDLKLMTE CECMCVLQAK 
        60         70         80         90        100
PISLEEDAQG DLILAGGPGP GDPLQLLLKR GWVISTELRR IGQKLAQDRW 
       110        120        130        140        150
ARVHSMSVRL TCHARSMVSE YSAVSRNSLK EMGEIEKLLM EKCSELSAVT 
       160        170        180        190        200
ERCLQVENEH VLKSMKACVS ETLSMLGQHF GQLLELALTR EVQALVRKID 
       210        220        230        240        250
ASDNIYTTES TTGNLFSLTQ EGAPLCRIIA KEGGVVALFK VCRQDSFRCL 
       260        270        280        290        300
YPQALRTLAS ICCVEEGVHQ LEKVDGVLCL ADILTDNSHS EATRAEAAAV 
       310        320        330        340        350
VAQVTSPHLP VTQHLSSFLE SMEEIVTALV KLCQEASSGE VFLLASAALA 
       360        370        380        390        400
NITFFDTMAC EMLLQLNAIR VLLEACSDKQ RVDTPYTRDQ IVTILANMSV 
       410        420        430        440        450
LEQCASDIIQ ENGVQLIMGM LSEKPRSGTP AEVAACERVQ QKAAVTLARL 
       460        470        480        490        500
SRDPDVAREA VRLSCMSRLI ELCRSPSERN SSDAVLVACL AALRRLAGVC 
       510        520        530 
PEGLQDSDFQ QLVQPRLVDS FLLCSNMEES FV

Show »

Length:532

Mass (Da):58,454

Checksum:ⁱ46C413794E504E42

GO

Isoform 3 (identifier: Q1MX18-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: Missing.
     204-238: ENEHVLKSMKACVSETLSMLGQHFGQLLELALTRE → MRREWEARMETHSPIWQNLLMRLDNCLALRLQSPL
     278-319: Missing.

« Hide

        10         20         30         40         50
MRREWEARME THSPIWQNLL MRLDNCLALR LQSPLVQALV RKIDASDNIY 
        60         70         80         90        100
TTESTTGNLF SLTQEGAPLC RIIAKVDGVL CLADILTDNS HSEATRAEAA 
       110        120        130        140        150
AVVAQVTSPH LPVTQHLSSF LESMEEIVTA LVKLCQEASS GEVFLLASAA 
       160        170        180        190        200
LANITFFDTM ACEMLLQLNA IRVLLEACSD KQRVDTPYTR DQIVTILANM 
       210        220        230        240        250
SVLEQCASDI IQENGVQLIM GMLSEKPRSG TPAEVAACER VQQKAAVTLA 
       260        270        280        290        300
RLSRDPDVAR EAVRLSCMSR LIELCRSPSE RNSSDAVLVA CLAALRRLAG 
       310        320        330 
VCPEGLQDSD FQQLVQPRLV DSFLLCSNME ESFV

Show »

Length:334

Mass (Da):36,669

Checksum:ⁱ1B97112A17E1ADE4

GO

Isoform 4 (identifier: Q1MX18-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-47: Missing.
278-319: Missing.

« Hide

        10         20         30         40         50
MMALPGGRHL DSVTLPGQRL HLMQVDSVQR WMEDLKLMTE CECMCVLQAK 
        60         70         80         90        100
PISLEEDAQG DLILAGGPGP GDPLQLLLKR GWVISTELRR IGQKLAQDRW 
       110        120        130        140        150
ARVHSMSVRL TCHARSMVSE YSAVSRNSLK EMGEIEKLLM EKCSELSAVT 
       160        170        180        190        200
ERCLQVENEH VLKSMKACVS ETLSMLGQHF GQLLELALTR EVQALVRKID 
       210        220        230        240        250
ASDNIYTTES TTGNLFSLTQ EGAPLCRIIA KVDGVLCLAD ILTDNSHSEA 
       260        270        280        290        300
TRAEAAAVVA QVTSPHLPVT QHLSSFLESM EEIVTALVKL CQEASSGEVF 
       310        320        330        340        350
LLASAALANI TFFDTMACEM LLQLNAIRVL LEACSDKQRV DTPYTRDQIV 
       360        370        380        390        400
TILANMSVLE QCASDIIQEN GVQLIMGMLS EKPRSGTPAE VAACERVQQK 
       410        420        430        440        450
AAVTLARLSR DPDVAREAVR LSCMSRLIEL CRSPSERNSS DAVLVACLAA 
       460        470        480        490
LRRLAGVCPE GLQDSDFQQL VQPRLVDSFL LCSNMEESFV

Show »

Length:490

Mass (Da):53,774

Checksum:ⁱ00FB28A1F62B99FA

GO

Isoform 5 (identifier: Q1MX18-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-47: Missing.
239-239: V → VQVESHSVTRLECSGAISAQCNLRLPGSSDSPASAS

« Hide

        10         20         30         40         50
MMALPGGRHL DSVTLPGQRL HLMQVDSVQR WMEDLKLMTE CECMCVLQAK 
        60         70         80         90        100
PISLEEDAQG DLILAGGPGP GDPLQLLLKR GWVISTELRR IGQKLAQDRW 
       110        120        130        140        150
ARVHSMSVRL TCHARSMVSE YSAVSRNSLK EMGEIEKLLM EKCSELSAVT 
       160        170        180        190        200
ERCLQVENEH VLKSMKACVS ETLSMLGQHF GQLLELALTR EVQVESHSVT 
       210        220        230        240        250
RLECSGAISA QCNLRLPGSS DSPASASQAL VRKIDASDNI YTTESTTGNL 
       260        270        280        290        300
FSLTQEGAPL CRIIAKEGGV VALFKVCRQD SFRCLYPQAL RTLASICCVE 
       310        320        330        340        350
EGVHQLEKVD GVLCLADILT DNSHSEATRA EAAAVVAQVT SPHLPVTQHL 
       360        370        380        390        400
SSFLESMEEI VTALVKLCQE ASSGEVFLLA SAALANITFF DTMACEMLLQ 
       410        420        430        440        450
LNAIRVLLEA CSDKQRVDTP YTRDQIVTIL ANMSVLEQCA SDIIQENGVQ 
       460        470        480        490        500
LIMGMLSEKP RSGTPAEVAA CERVQQKAAV TLARLSRDPD VAREAVRLSC 
       510        520        530        540        550
MSRLIELCRS PSERNSSDAV LVACLAALRR LAGVCPEGLQ DSDFQQLVQP 
       560 
RLVDSFLLCS NMEESFV

Show »

Length:567

Mass (Da):61,981

Checksum:ⁱ33D225D70DCD9A67

GO

Isoform 6 (identifier: Q1MX18-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-47: Missing.
539-579: ALRRLAGVCPEGLQDSDFQQLVQPRLVDSFLLCSNMEESFV → MGIQLQVKKTNISALLLWFLFWHIQGCSA

« Hide

        10         20         30         40         50
MMALPGGRHL DSVTLPGQRL HLMQVDSVQR WMEDLKLMTE CECMCVLQAK 
        60         70         80         90        100
PISLEEDAQG DLILAGGPGP GDPLQLLLKR GWVISTELRR IGQKLAQDRW 
       110        120        130        140        150
ARVHSMSVRL TCHARSMVSE YSAVSRNSLK EMGEIEKLLM EKCSELSAVT 
       160        170        180        190        200
ERCLQVENEH VLKSMKACVS ETLSMLGQHF GQLLELALTR EVQALVRKID 
       210        220        230        240        250
ASDNIYTTES TTGNLFSLTQ EGAPLCRIIA KEGGVVALFK VCRQDSFRCL 
       260        270        280        290        300
YPQALRTLAS ICCVEEGVHQ LEKVDGVLCL ADILTDNSHS EATRAEAAAV 
       310        320        330        340        350
VAQVTSPHLP VTQHLSSFLE SMEEIVTALV KLCQEASSGE VFLLASAALA 
       360        370        380        390        400
NITFFDTMAC EMLLQLNAIR VLLEACSDKQ RVDTPYTRDQ IVTILANMSV 
       410        420        430        440        450
LEQCASDIIQ ENGVQLIMGM LSEKPRSGTP AEVAACERVQ QKAAVTLARL 
       460        470        480        490        500
SRDPDVAREA VRLSCMSRLI ELCRSPSERN SSDAVLVACL AMGIQLQVKK 
       510        520
TNISALLLWF LFWHIQGCSA

Show »

Length:520

Mass (Da):57,188

Checksum:ⁱ73DB667C8BEE3113

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0A0MSI1	A0A0A0MSI1_HUMAN		Protein inscuteable homolog Protein inscuteable homolog	INSC	566	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	212	M → T in BAE17134 (Ref. 2) Curated	1
Sequence conflictⁱ	216	V → M in BAE17135 (Ref. 2) Curated	1
Sequence conflictⁱ	226	H → R in BAE17133 (Ref. 2) Curated	1
Sequence conflictⁱ	251	N → D in BAE17134 (Ref. 2) Curated	1
Sequence conflictⁱ	513	M → T in BAE17135 (Ref. 2) Curated	1
Sequence conflictⁱ	577 – 578	SF → GS in BAE17136 (Ref. 2) Curated	2

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051073	333	D → N. Corresponds to variant dbSNP:rs17507577Ensembl.		1
Natural variantⁱVAR_027852	450	Q → R. Corresponds to variant dbSNP:rs7123855Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_020946	1 – 203	Missing in isoform 3. 1 PublicationAdd BLAST	203
Alternative sequenceⁱVSP_020947	1 – 47	Missing in isoform 2, isoform 4, isoform 5 and isoform 6. 3 PublicationsAdd BLAST	47
Alternative sequenceⁱVSP_020948	204 – 238	ENEHV…ALTRE → MRREWEARMETHSPIWQNLL MRLDNCLALRLQSPL in isoform 3. 1 PublicationAdd BLAST	35
Alternative sequenceⁱVSP_020949	239	V → VQVESHSVTRLECSGAISAQ CNLRLPGSSDSPASAS in isoform 5. 1 Publication	1
Alternative sequenceⁱVSP_020950	278 – 319	Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST	42
Alternative sequenceⁱVSP_054159	539 – 579	ALRRL…EESFV → MGIQLQVKKTNISALLLWFL FWHIQGCSA in isoform 6. 1 PublicationAdd BLAST	41

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB236158 mRNA Translation: BAE93463.1 AB236159 mRNA Translation: BAE93464.1 AB231744 mRNA Translation: BAE46891.1 AB231745 mRNA Translation: BAE17133.1 AB231746 mRNA Translation: BAE17134.1 AB231747 mRNA Translation: BAE17135.1 AB231748 mRNA Translation: BAE17136.1 AC090744 Genomic DNA No translation available. BC127700 mRNA Translation: AAI27701.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41621.1 [Q1MX18-1] CCDS41622.1 [Q1MX18-2] CCDS60735.1 [Q1MX18-6] CCDS60736.1 [Q1MX18-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001027024.3, NM_001031853.4 [Q1MX18-1] NP_001036001.1, NM_001042536.2 [Q1MX18-2] NP_001265242.1, NM_001278313.1 [Q1MX18-2] NP_001265243.1, NM_001278314.1 NP_001265244.1, NM_001278315.1 [Q1MX18-6] NP_001265245.1, NM_001278316.1 [Q1MX18-4] XP_006718290.1, XM_006718227.3 [Q1MX18-2] XP_011518388.1, XM_011520086.1 [Q1MX18-6] XP_016873186.1, XM_017017697.1 [Q1MX18-2]

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q1MX18	Isoform 2 of Protein inscuteable homolog		HUMAN		532	UniRef90_Q1MX18
Uncharacterized protein		NOMLE		566
INSC spindle orientation adaptor protein		MACFA		554
INSC spindle orientation adaptor protein		SAIBB		510
INSC spindle orientation adaptor protein		THEGE		490
+20
Q1MX18-3	Insc_C domain-containing protein		MYOLU		260	UniRef90_Q1MX18-3
+1
Q1MX18-5	protein inscuteable homolog isoform X1		CASCN		577	UniRef90_Q1MX18-5
INSC spindle orientation adaptor protein		PANTR		566
INSC spindle orientation adaptor protein		CERAT		566
INSC spindle orientation adaptor protein		MACFA		566
INSC spindle orientation adaptor protein		MANLE		566
+76
Q1MX18-6	protein inscuteable homolog		DELLE		649	UniRef90_Q1MX18-6
INSC spindle orientation adaptor protein		NANGA		533
INSC spindle orientation adaptor protein		CEBIM		527
protein inscuteable homolog		BALMU		525
INSC spindle orientation adaptor protein		RABIT		522
+19

Protein	Similar proteins		Species	Score	Length	Source
Q1MX18	Protein inscuteable homolog	)	MOUSE		579	UniRef50_Q1MX18
Isoform 2 of Protein inscuteable homolog		HUMAN		532
Uncharacterized protein		NOMLE		566
INSC spindle orientation adaptor protein		MACFA		554
INSC spindle orientation adaptor protein		SAIBB		510
+279
Q1MX18-3	Insc_C domain-containing protein		MYOLU		260	UniRef50_Q1MX18-3
INSC spindle orientation adaptor protein		NOTFU		345
INSC protein (Fragment)		GYMTI		302
INSC protein (Fragment)		Notiomystis cincta		340
INSC protein (Fragment)		EOLRO		302
+22
Q1MX18-5	protein inscuteable homolog isoform X1		CASCN		577	UniRef50_Q1MX18-5
INSC spindle orientation adaptor protein		THEGE		566
Uncharacterized protein		NOMLE		566
INSC spindle orientation adaptor protein		GORGO		566
INSC spindle orientation adaptor protein		MACFA		566
+358

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB236158 mRNA Translation: BAE93463.1 AB236159 mRNA Translation: BAE93464.1 AB231744 mRNA Translation: BAE46891.1 AB231745 mRNA Translation: BAE17133.1 AB231746 mRNA Translation: BAE17134.1 AB231747 mRNA Translation: BAE17135.1 AB231748 mRNA Translation: BAE17136.1 AC090744 Genomic DNA No translation available. BC127700 mRNA Translation: AAI27701.1
CCDSⁱ	CCDS41621.1 [Q1MX18-1] CCDS41622.1 [Q1MX18-2] CCDS60735.1 [Q1MX18-6] CCDS60736.1 [Q1MX18-4]
RefSeqⁱ	NP_001027024.3, NM_001031853.4 [Q1MX18-1] NP_001036001.1, NM_001042536.2 [Q1MX18-2] NP_001265242.1, NM_001278313.1 [Q1MX18-2] NP_001265243.1, NM_001278314.1 NP_001265244.1, NM_001278315.1 [Q1MX18-6] NP_001265245.1, NM_001278316.1 [Q1MX18-4] XP_006718290.1, XM_006718227.3 [Q1MX18-2] XP_011518388.1, XM_011520086.1 [Q1MX18-6] XP_016873186.1, XM_017017697.1 [Q1MX18-2]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3SF4	X-ray	2.60	D/E/F	70-116	[»]
AlphaFoldDBⁱ	Q1MX18
SMRⁱ	Q1MX18
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	132426, 37 interactors
CORUMⁱ	Q1MX18
IntActⁱ	Q1MX18, 13 interactors
STRINGⁱ	9606.ENSP00000368872

PTM databases

iPTMnetⁱ	Q1MX18
PhosphoSitePlusⁱ	Q1MX18

Genetic variation databases

BioMutaⁱ	INSC
DMDMⁱ	116248172

Proteomic databases

EPDⁱ	Q1MX18
MassIVEⁱ	Q1MX18
PaxDbⁱ	Q1MX18
PeptideAtlasⁱ	Q1MX18
PRIDEⁱ	Q1MX18
ProteomicsDBⁱ	61231 [Q1MX18-1] 61232 [Q1MX18-2] 61235 [Q1MX18-5] 69

Protocols and materials databases

Antibodypediaⁱ	48935, 189 antibodies from 23 providers
The DNASU plasmid repository More...DNASUⁱ	387755

Genome annotation databases

Ensemblⁱ	ENST00000379554.7; ENSP00000368872.3; ENSG00000188487.12 ENST00000379556.8; ENSP00000368874.3; ENSG00000188487.12 [Q1MX18-2] ENST00000525218.1; ENSP00000436113.1; ENSG00000188487.12 [Q1MX18-4] ENST00000528567.5; ENSP00000435022.1; ENSG00000188487.12 [Q1MX18-6] ENST00000530161.5; ENSP00000436194.1; ENSG00000188487.12 [Q1MX18-2]
GeneIDⁱ	387755
KEGGⁱ	hsa:387755
MANE-Selectⁱ	ENST00000379556.8; ENSP00000368874.3; NM_001042536.3; NP_001036001.1 [Q1MX18-2]
UCSCⁱ	uc001mly.5, human [Q1MX18-1]

Organism-specific databases

CTDⁱ	387755
GeneCardsⁱ	INSC
HGNCⁱ	HGNC:33116, INSC
HPAⁱ	ENSG00000188487, Tissue enriched (parathyroid)
MIMⁱ	610668, gene
neXtProtⁱ	NX_Q1MX18
OpenTargetsⁱ	ENSG00000188487
PharmGKBⁱ	PA162392191
VEuPathDBⁱ	HostDB:ENSG00000188487
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG502QRY2, Eukaryota
GeneTreeⁱ	ENSGT00390000001511
InParanoidⁱ	Q1MX18
OrthoDBⁱ	569133at2759
PhylomeDBⁱ	Q1MX18
TreeFamⁱ	TF323559

Enzyme and pathway databases

PathwayCommonsⁱ	Q1MX18
SignaLinkⁱ	Q1MX18

Miscellaneous databases

BioGRID-ORCSⁱ	387755, 8 hits in 1070 CRISPR screens
ChiTaRSⁱ	INSC, human
GenomeRNAiⁱ	387755
Pharosⁱ	Q1MX18, Tbio
Protein Ontology More...PROⁱ	PR:Q1MX18
RNActⁱ	Q1MX18, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000188487, Expressed in tibia and 119 other tissues
ExpressionAtlasⁱ	Q1MX18, baseline and differential
Genevisibleⁱ	Q1MX18, HS

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit 6.20.200.10, 1 hit
IDEALⁱ	IID00323
InterProⁱ	View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000225, Armadillo IPR045789, Insc_C IPR031938, INSC_LBD IPR038205, INSC_LBD_sf IPR039921, Inscuteable
PANTHERⁱ	PTHR21386, PTHR21386, 1 hit
Pfamⁱ	View protein in Pfam PF19427, Insc_C, 1 hit PF16748, INSC_LBD, 1 hit
SMARTⁱ	View protein in SMART SM00185, ARM, 3 hits
SUPFAMⁱ	SSF48371, SSF48371, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	INSC_HUMAN
Accessionⁱ	Q1MX18Primary (citable) accession number: Q1MX18 Secondary accession number(s): A0PJX5 Q4AC98
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
	Last sequence update:	May 30, 2006
	Last modified:	May 25, 2022
	This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q1MX18 (INSC_HUMAN)

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Keywords - Coding sequence diversityⁱ

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