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Entry version 93 (02 Jun 2021)
Sequence version 2 (31 Oct 2006)
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Protein

Inner centromere protein-related protein pic1

Gene

pic1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for chromosome segregation and cytokinesis. Has a role in sister chromatid cohesion and condensation.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • mitotic sister chromatid segregation Source: PomBase

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processChromosome partition

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inner centromere protein-related protein pic1
Short name:
INCENP-related protein pic1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pic1
ORF Names:SPBC336.15, SPBC685.01
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPBC336.15, pic1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPBC336.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002554361 – 1018Inner centromere protein-related protein pic1Add BLAST1018

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei171Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q1MTN3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q1MTN3

PRoteomics IDEntifications database

More...
PRIDEi
Q1MTN3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q1MTN3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ark1.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
276782, 8 interactors

Database of interacting proteins

More...
DIPi
DIP-59225N

Protein interaction database and analysis system

More...
IntActi
Q1MTN3, 1 interactor

STRING: functional protein association networks

More...
STRINGi
4896.SPBC336.15.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q1MTN3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni184 – 207DisorderedSequence analysisAdd BLAST24
Regioni247 – 287DisorderedSequence analysisAdd BLAST41
Regioni306 – 365DisorderedSequence analysisAdd BLAST60
Regioni522 – 556DisorderedSequence analysisAdd BLAST35
Regioni570 – 756DisorderedSequence analysisAdd BLAST187
Regioni781 – 813DisorderedSequence analysisAdd BLAST33
Regioni848 – 867DisorderedSequence analysisAdd BLAST20
Regioni877 – 944DisorderedSequence analysisAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi185 – 200Polar residuesSequence analysisAdd BLAST16
Compositional biasi265 – 287Polar residuesSequence analysisAdd BLAST23
Compositional biasi306 – 337Polar residuesSequence analysisAdd BLAST32
Compositional biasi522 – 555Polar residuesSequence analysisAdd BLAST34
Compositional biasi625 – 647Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi648 – 666Polar residuesSequence analysisAdd BLAST19
Compositional biasi704 – 721Polar residuesSequence analysisAdd BLAST18
Compositional biasi722 – 737Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi740 – 756Polar residuesSequence analysisAdd BLAST17
Compositional biasi781 – 806Polar residuesSequence analysisAdd BLAST26
Compositional biasi881 – 923Polar residuesSequence analysisAdd BLAST43

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the INCENP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1181, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_296495_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q1MTN3

Identification of Orthologs from Complete Genome Data

More...
OMAi
SETMDWL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q1MTN3

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005635, Inner_centromere_prot_ARK-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03941, INCENP_ARK-bind, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q1MTN3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSNGSELWF NKELEYSQQL TNGKMKEFFF LVSETMDWLN EHMLEVSKLQ
60 70 80 90 100
LESDIYELVR TPTKIKEKYS TPRLSPVHRC ALPTPRMRLT SIQHQLEEAA
110 120 130 140 150
VEGYKSGESN TVKEPKELHT ATNTETQFDD DRDSTKLSSE YVKDDIVNKS
160 170 180 190 200
TKGGVSPIKE TRLPTNLPAF SPTSVERRFT EWNVPLRETS PSPSETADSP
210 220 230 240 250
NKLPKQKHPA YSFVTLPKRE EILKRPASLH SRVESTNSFI NQLNRRRTKD
260 270 280 290 300
NLTNNPEISL DEPIKALPST TSDAPSSLLN TNVSSSPSKF RKFLSSVIPA
310 320 330 340 350
KTDLSAKESL TSSTRLSTSY KTRKRSSGVA FSSETVTSSS KERKRSVENE
360 370 380 390 400
MLKPHPTIFE SPPEITSFDK SNAVEAEALT AKLKSNEERL PVSSQPGSDA
410 420 430 440 450
KSQEFDFFEA KIPDSIAKLN ELTASNENHY ELKTYDRAER LRQKIQEVSS
460 470 480 490 500
NKRLIPSTPP TKKPINAVLD AAKNSAAKDL HLAKMKLNNK NDESSLSPAK
510 520 530 540 550
SHAVITQAPK IPLISTFTRL STRKSSNDFN SSNSRPSSNA LKSDANENTD
560 570 580 590 600
SSLPPSKKEF IEKSLHKLSE PLHDDSRQNS DHNFAPHSRP IAIRVATASQ
610 620 630 640 650
RELEQTEKRK AKNGAANASN MESRSSENET HRFKKFYGKE RELSNNEFPS
660 670 680 690 700
RQTKTVTSAN SSNIRDMEHT ISDKPRSEPD AIPSSKSMHS NKPFEEKSEK
710 720 730 740 750
PTTKRLVTNP SNVNASWHSN MLKRQEDLRK KKPLTDNGAT SRHMLKSGLT
760 770 780 790 800
RVTSKPTQRF ANELAEDMSL AFHSTIPKKM EPDSVTSVTQ PSVGSLRNNF
810 820 830 840 850
DIGTTNSQNE DRKKKIAAQK NKNPVHGNVG LTNQHGFKTM HHNVNPFTKQ
860 870 880 890 900
NGIMKGKLPS SSTSQSNKPF IEKASMHAPA KGRNSSMQEP SSKSPLLKTP
910 920 930 940 950
KSNYFPGYGS LSPNTSVELP EINSDYSDDS DDEGNKKKVN LPSWAESPEL
960 970 980 990 1000
REQLKRQQKW DPDKIFGMIK PLQMDEYFRS KDRSKIRFRP RSSSADWSSQ
1010
DRLTQAEIDN YKKNMGFL
Length:1,018
Mass (Da):114,476
Last modified:October 31, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i510368FCD2E8098C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB58167.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T40253

NCBI Reference Sequences

More...
RefSeqi
NP_596135.2, NM_001022053.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC336.15.1; SPBC336.15.1:pep; SPBC336.15

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2540250

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC336.15

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB58167.1
PIRiT40253
RefSeqiNP_596135.2, NM_001022053.2

3D structure databases

SMRiQ1MTN3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi276782, 8 interactors
DIPiDIP-59225N
IntActiQ1MTN3, 1 interactor
STRINGi4896.SPBC336.15.1

PTM databases

iPTMnetiQ1MTN3

Proteomic databases

MaxQBiQ1MTN3
PaxDbiQ1MTN3
PRIDEiQ1MTN3

Genome annotation databases

EnsemblFungiiSPBC336.15.1; SPBC336.15.1:pep; SPBC336.15
GeneIDi2540250
KEGGispo:SPBC336.15

Organism-specific databases

PomBaseiSPBC336.15, pic1
VEuPathDBiFungiDB:SPBC336.15

Phylogenomic databases

eggNOGiKOG1181, Eukaryota
HOGENOMiCLU_296495_0_0_1
InParanoidiQ1MTN3
OMAiSETMDWL
PhylomeDBiQ1MTN3

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q1MTN3

Family and domain databases

InterProiView protein in InterPro
IPR005635, Inner_centromere_prot_ARK-bd
PfamiView protein in Pfam
PF03941, INCENP_ARK-bind, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPIC1_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1MTN3
Secondary accession number(s): Q9UST0, Q9Y7L3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: June 2, 2021
This is version 93 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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