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Protein

Tyrosine-protein phosphatase

Gene

ptpn4b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei820SubstrateUniRule annotation1
Active sitei852Phosphocysteine intermediateUniRule annotation1
Binding sitei896SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-DRE-166016 Toll Like Receptor 4 (TLR4) Cascade

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphataseUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:ptpn4bImported
Synonyms:si:rp71-1n18.2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 22

Organism-specific databases

ZFINiZDB-GENE-030131-6259 ptpn4b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000000183
ExpressionAtlasiQ1MTL1 baseline

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ1MTL1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 312FERMInterPro annotationAdd BLAST284
Domaini521 – 593PDZInterPro annotationAdd BLAST73
Domaini660 – 911Tyrosine-protein phosphataseInterPro annotationAdd BLAST252
Domaini828 – 902TYR_PHOSPHATASE_2InterPro annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni852 – 858Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG410KDUQ Eukaryota
COG5599 LUCA
GeneTreeiENSGT00760000118823
HOGENOMiHOG000007048
HOVERGENiHBG008322
KOiK18037
OMAiNRTRINT
PhylomeDBiQ1MTL1

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR012151 Tyr_Pase_non-rcpt_typ-3/4
IPR000387 TYR_PHOSPHATASE_dom
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF00595 PDZ, 1 hit
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000927 Tyr-Ptase_nr3, 1 hit
PRINTSiPR00935 BAND41
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SM00228 PDZ, 1 hit
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF50156 SSF50156, 1 hit
SSF52799 SSF52799, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit
PS50106 PDZ, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

Q1MTL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTARFRLPAG RSYDVGALEE ARERQHAQVE CNVLLLDNTV QTFRVNKQDQ
60 70 80 90 100
GQILLDVVYK HLELTERDYF GLQLADDTSD TQRWLDPNKP VRKQLKRPSP
110 120 130 140 150
HNLRFRVKFF VGDPGKLQEE YTRYLYFLQL KQDILSGRLP CPQNTAVLLA
160 170 180 190 200
SYAVQAELGD YSHSEHLSGY LSEYSFIPNP PQDFEKEVAK LHQEHNGLTP
210 220 230 240 250
AQSEFNYLNA ARTLELYGVE LHYARDHCNT EIYVGVLSAG ISVYKDRVRV
260 270 280 290 300
NHFPWFKIVK ISFKSKQFFI QLRKELTECR ESLLGFNMMN YRACKNLWKS
310 320 330 340 350
CVENHTFFRL ERPVPPERNL FLHYFTLGSK FRYCGRTEAQ SVQYGKERGN
360 370 380 390 400
KNRVFARSPS KPLVRRLMSG LDWETVSRNS LSDDRLETQS LPNRSPPDSP
410 420 430 440 450
DHSNSVFTTE GARIRPSSIG HLVDHVIDDS PCQTFTNHKS ASSTQANSIS
460 470 480 490 500
LDSTPSPDVT TDEQPPALPP KQFRKDPLNH NGRSQSQHEL DDHDHLSELY
510 520 530 540 550
NVPAASGKSM NGAVPHDNLV LIKMRPDENG RFGFNVKGGV DQRMPIIVSR
560 570 580 590 600
VAPGTPADMC VPRLNEGDQV VLINGRDISD HTHDDVVMII KASCEDQSGE
610 620 630 640 650
LILLVRPNAI YDVDEEQEKL DLEPDFQYIP EACGLESHSE ADSLRSSIQL
660 670 680 690 700
LRDGLASGTV PAQFDQLYRK RPGMSMSCAR LPQNVSKNRY RDISPYDSTR
710 720 730 740 750
VVLKGTEDYI NANFINMDVP SKGEVRRYIA CQGPLPGTCS DFWQMVWEQS
760 770 780 790 800
AALVVMLTTQ VERGRYWPNV SASGTYGGFQ VTCVSEEGNS AYLLRDLTLT
810 820 830 840 850
HLESKEERQI CQMQYLAWPD HGVPDDSSDF LNFVSQVRSK RADGPEPVVV
860 870 880 890 900
HCSAGIGRTG VLITMETAMC LIEGGQSVYP LDIVRTMRDQ RAMMIQTPSQ
910 920 930
YRFVCEAILK VYDEEIVKPF ETELPVEKEE
Length:930
Mass (Da):105,654
Last modified:February 20, 2007 - v2
Checksum:i057F4E5F7F5F65C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645755 Genomic DNA No translation available.
RefSeqiNP_001037778.2, NM_001044313.2
UniGeneiDr.47843

Genome annotation databases

EnsembliENSDART00000125423; ENSDARP00000105661; ENSDARG00000000183
GeneIDi407634
KEGGidre:407634

Similar proteinsi

Entry informationi

Entry nameiQ1MTL1_DANRE
AccessioniPrimary (citable) accession number: Q1MTL1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 30, 2006
Last sequence update: February 20, 2007
Last modified: May 23, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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