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Entry version 126 (02 Jun 2021)
Sequence version 1 (30 May 2006)
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Protein

Ubiquitin carboxyl-terminal hydrolase

Gene

usp5

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).UniRule annotationARBA annotation EC:3.4.19.12

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi197ZincUniRule annotation1
Metal bindingi200ZincUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei207SubstrateUniRule annotation1
Metal bindingi217ZincUniRule annotation1
Metal bindingi230ZincUniRule annotation1
Binding sitei257SubstrateUniRule annotation1
Binding sitei259Substrate; via carbonyl oxygenUniRule annotation1
Binding sitei262SubstrateUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei333NucleophileUniRule annotation1
Active sitei813Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri195 – 267UBP-typePROSITE-ProRule annotationAdd BLAST73

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseUniRule annotation
Biological processUbl conjugation pathwayUniRule annotation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-5689880, Ub-specific processing proteases
R-DRE-8866652, Synthesis of active ubiquitin: roles of E1 and E2 enzymes

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C19.012

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolaseUniRule annotation (EC:3.4.19.12UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:usp5Imported
ORF Names:CH211-69G19.5-001Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-040426-2584, usp5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000014517, Expressed in embryo and 36 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000036699

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini195 – 267UBP-typeInterPro annotationAdd BLAST73
Domaini324 – 851USPInterPro annotationAdd BLAST528
Domaini651 – 692UBAInterPro annotationAdd BLAST42
Domaini718 – 758UBAInterPro annotationAdd BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni67 – 98DisorderedSequence analysisAdd BLAST32
Regioni219 – 222Substrate bindingUniRule annotation4
Regioni387 – 408DisorderedSequence analysisAdd BLAST22
Regioni499 – 522DisorderedSequence analysisAdd BLAST24
Regioni766 – 792DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi74 – 89Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi499 – 513Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.UniRule annotationARBA annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri195 – 267UBP-typePROSITE-ProRule annotationAdd BLAST73

Keywords - Domaini

RepeatARBA annotation, Zinc-fingerARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0944, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156036

Database of Orthologous Groups

More...
OrthoDBi
556111at2759

TreeFam database of animal gene trees

More...
TreeFami
TF300576

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR015940, UBA
IPR009060, UBA-like_sf
IPR016652, Ubiquitinyl_hydrolase
IPR041432, UBP13_Znf-UBP_var
IPR018200, USP_CS
IPR028889, USP_dom
IPR013083, Znf_RING/FYVE/PHD
IPR001607, Znf_UBP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00627, UBA, 2 hits
PF00443, UCH, 1 hit
PF02148, zf-UBP, 1 hit
PF17807, zf-UBP_var, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF016308, UBP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00165, UBA, 2 hits
SM00290, ZnF_UBP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46934, SSF46934, 1 hit
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50030, UBA, 2 hits
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit
PS50271, ZF_UBP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q1MT86-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEVSEILMS VLSAIRVPRP GDRVHKDECA FSFSSPESEG GLYVCMNSFL
60 70 80 90 100
GFGSKYVDRH HAKTGQRAYL HITRTRKTQK EDDPNSGSGD PPKKKPTRLA
110 120 130 140 150
IGIEGGFDVE QEQYEEEVKV VLFPDRQEVT LDDLSSMPDV VRERVSLSVA
160 170 180 190 200
ELQAADSVSH TLQVQQWDGE VRQESKHAAE LKQLDNGLKI PPSGWKCEVC
210 220 230 240 250
ELQENLWMNL TDGKVLCGRR YFDGSGGNNH ALLYYQQTGY PLAVKLGTIT
260 270 280 290 300
PDGADVYSYD EDDMVLDSKL PEHLSHFGID MMTMEKTERT MTELEIAVNQ
310 320 330 340 350
RVGEWEVIQE SGTTLRPLWG PGLTGMKNLG NSCYLNSVMQ VLFTIPDFQT
360 370 380 390 400
KYVSNIDKIF DEAPSDPTQD FKTQVAKLGY GLLSGEYSKP APDPADEPNT
410 420 430 440 450
SAEPRGDQVG IAPRMFKALV GRGHPEFSTN RQQDAQEFLL HFINMVERNC
460 470 480 490 500
RSGMNPSEAF RFLVEEKIVC QQSQKAKYTQ RVDYIVQLPV PMDQATNMDE
510 520 530 540 550
LQEAERRREE AESSGAPPPV APRAQIPFAA CLAALSEPET LTDFWSSAVQ
560 570 580 590 600
AKTTATKTTR FASFPDHLVI QIKKFTFGLD WVPKKLDVSI DVPETLDLNA
610 620 630 640 650
LRAMGQQPGE ELLPEVAPPP LMTPDVEVKG ILGSHGNEED DSLYSPLLSP
660 670 680 690 700
VLDDSTVSQL CEMGFPLEAC RKAVYYTGNT GIDAAMNWVM GHMDDPDFAA
710 720 730 740 750
PLVLPGSSSA PGTTPTESLP EEHLATIVSM GFSRDQATRA LRATNNVLER
760 770 780 790 800
AVDWIFSHLD DLESMDVSEG GRSEGGSEAS REPPPGPRVR DGTGKYELFA
810 820 830 840 850
FISHMGSSTM CGHYVCHIKK DQQWVIFNDQ KVCASEKPPK DLGYLYFYRR

VVE
Length:853
Mass (Da):94,797
Last modified:May 30, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i538687829D5B6FFD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W4C4F8W4C4_DANRE
Ubiquitin carboxyl-terminal hydrola...
usp5
834Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU467865 Genomic DNA No translation available.
AL929502 Genomic DNA Translation: CAK04985.1

NCBI Reference Sequences

More...
RefSeqi
XP_005173534.1, XM_005173477.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000029121; ENSDARP00000036699; ENSDARG00000014517
ENSDART00000185963; ENSDARP00000154617; ENSDARG00000114598

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
406618

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU467865 Genomic DNA No translation available.
AL929502 Genomic DNA Translation: CAK04985.1
RefSeqiXP_005173534.1, XM_005173477.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000036699

Protein family/group databases

MEROPSiC19.012

Genome annotation databases

EnsembliENSDART00000029121; ENSDARP00000036699; ENSDARG00000014517
ENSDART00000185963; ENSDARP00000154617; ENSDARG00000114598
GeneIDi406618

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8078
ZFINiZDB-GENE-040426-2584, usp5

Phylogenomic databases

eggNOGiKOG0944, Eukaryota
GeneTreeiENSGT00940000156036
OrthoDBi556111at2759
TreeFamiTF300576

Enzyme and pathway databases

ReactomeiR-DRE-5689880, Ub-specific processing proteases
R-DRE-8866652, Synthesis of active ubiquitin: roles of E1 and E2 enzymes

Gene expression databases

BgeeiENSDARG00000014517, Expressed in embryo and 36 other tissues

Family and domain databases

Gene3Di3.30.40.10, 3 hits
InterProiView protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR015940, UBA
IPR009060, UBA-like_sf
IPR016652, Ubiquitinyl_hydrolase
IPR041432, UBP13_Znf-UBP_var
IPR018200, USP_CS
IPR028889, USP_dom
IPR013083, Znf_RING/FYVE/PHD
IPR001607, Znf_UBP
PfamiView protein in Pfam
PF00627, UBA, 2 hits
PF00443, UCH, 1 hit
PF02148, zf-UBP, 1 hit
PF17807, zf-UBP_var, 1 hit
PIRSFiPIRSF016308, UBP, 1 hit
SMARTiView protein in SMART
SM00165, UBA, 2 hits
SM00290, ZnF_UBP, 1 hit
SUPFAMiSSF46934, SSF46934, 1 hit
SSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50030, UBA, 2 hits
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit
PS50271, ZF_UBP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ1MT86_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q1MT86
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 30, 2006
Last sequence update: May 30, 2006
Last modified: June 2, 2021
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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