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UniProtKB - Q1MT02 (Q1MT02_DANRE)
Protein
Endothelin-2
Gene
edn2
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- endothelin B receptor binding Source: GO_Central
- hormone activity Source: GO_Central
GO - Biological processi
- cellular calcium ion homeostasis Source: GO_Central
- positive regulation of prostaglandin-endoperoxide synthase activity Source: GO_Central
- regulation of systemic arterial blood pressure by endothelin Source: GO_Central
- regulation of vasoconstriction Source: InterPro
- vein smooth muscle contraction Source: GO_Central
Keywordsi
Molecular function | Vasoactive, VasoconstrictorARBA annotation |
Enzyme and pathway databases
Reactomei | R-DRE-375276, Peptide ligand-binding receptors R-DRE-416476, G alpha (q) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Endothelin-2ARBA annotationAlternative name(s): Preproendothelin-2ARBA annotation |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-060503-774, edn2 |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_5004194239 | 24 – 164 | Endothelin-2Sequence analysisAdd BLAST | 141 |
Proteomic databases
PaxDbi | Q1MT02 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000070578, Expressed in heart and 16 other tissues |
Interactioni
GO - Molecular functioni
- endothelin B receptor binding Source: GO_Central
- hormone activity Source: GO_Central
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000094560 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 46 – 67 | ENDInterPro annotationAdd BLAST | 22 | |
Domaini | 92 – 113 | ENDInterPro annotationAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the endothelin/sarafotoxin family.ARBA annotation
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
eggNOGi | ENOG502S5KM, Eukaryota |
GeneTreei | ENSGT00950000183053 |
HOGENOMi | CLU_090013_2_0_1 |
InParanoidi | Q1MT02 |
OMAi | MASFTCK |
OrthoDBi | 1264335at2759 |
PhylomeDBi | Q1MT02 |
TreeFami | TF333184 |
Family and domain databases
InterProi | View protein in InterPro IPR020475, Endothelin IPR019764, Endothelin_toxin_CS IPR001928, Endothln-like_toxin IPR015658, ET-2 |
PANTHERi | PTHR13874, PTHR13874, 1 hit PTHR13874:SF9, PTHR13874:SF9, 1 hit |
Pfami | View protein in Pfam PF00322, Endothelin, 1 hit |
PRINTSi | PR00365, ENDOTHELIN |
SMARTi | View protein in SMART SM00272, END, 2 hits |
PROSITEi | View protein in PROSITE PS00270, ENDOTHELIN, 2 hits |
i Sequence
Sequence statusi: Complete.
Q1MT02-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAFTLQTALL VLATLCVLQQ GFGYPLSKQP EASSNPPAHK RVRTKRCSCS
60 70 80 90 100
SWLDNECIYF CHLDIIWVNT PNKITPLGLG SPLSRRRRST GRCECANPAD
110 120 130 140 150
RTCSSFCHTS SEDPDMEFVT QLDNQSDHKD KTSDHLLLSL RRVVKHNLMT
160
ASRFASPKKK SRIS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL954687 Genomic DNA No translation available. |
RefSeqi | NP_001038650.1, NM_001045185.1 |
Genome annotation databases
Ensembli | ENSDART00000103784; ENSDARP00000094560; ENSDARG00000070578 |
GeneIDi | 569550 |
KEGGi | dre:569550 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL954687 Genomic DNA No translation available. |
RefSeqi | NP_001038650.1, NM_001045185.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000094560 |
Proteomic databases
PaxDbi | Q1MT02 |
Genome annotation databases
Ensembli | ENSDART00000103784; ENSDARP00000094560; ENSDARG00000070578 |
GeneIDi | 569550 |
KEGGi | dre:569550 |
Organism-specific databases
CTDi | 1907 |
ZFINi | ZDB-GENE-060503-774, edn2 |
Phylogenomic databases
eggNOGi | ENOG502S5KM, Eukaryota |
GeneTreei | ENSGT00950000183053 |
HOGENOMi | CLU_090013_2_0_1 |
InParanoidi | Q1MT02 |
OMAi | MASFTCK |
OrthoDBi | 1264335at2759 |
PhylomeDBi | Q1MT02 |
TreeFami | TF333184 |
Enzyme and pathway databases
Reactomei | R-DRE-375276, Peptide ligand-binding receptors R-DRE-416476, G alpha (q) signalling events |
Gene expression databases
Bgeei | ENSDARG00000070578, Expressed in heart and 16 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR020475, Endothelin IPR019764, Endothelin_toxin_CS IPR001928, Endothln-like_toxin IPR015658, ET-2 |
PANTHERi | PTHR13874, PTHR13874, 1 hit PTHR13874:SF9, PTHR13874:SF9, 1 hit |
Pfami | View protein in Pfam PF00322, Endothelin, 1 hit |
PRINTSi | PR00365, ENDOTHELIN |
SMARTi | View protein in SMART SM00272, END, 2 hits |
PROSITEi | View protein in PROSITE PS00270, ENDOTHELIN, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | Q1MT02_DANRE | |
Accessioni | Q1MT02Primary (citable) accession number: Q1MT02 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 30, 2006 |
Last sequence update: | May 30, 2006 | |
Last modified: | September 29, 2021 | |
This is version 90 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |