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Protein

Molybdenum cofactor guanylyltransferase

Gene

mobA

Organism
Rhizobium leguminosarum bv. viciae (strain 3841)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.UniRule annotation

Catalytic activityi

GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei28GTPUniRule annotation1
Binding sitei56GTPUniRule annotation1
Binding sitei69GTPUniRule annotation1
Metal bindingi103MagnesiumUniRule annotation1
Binding sitei103GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 18GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMolybdenum cofactor biosynthesis
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdenum cofactor guanylyltransferaseUniRule annotation (EC:2.7.7.77UniRule annotation)
Short name:
MoCo guanylyltransferaseUniRule annotation
Alternative name(s):
GTP:molybdopterin guanylyltransferaseUniRule annotation
Mo-MPT guanylyltransferaseUniRule annotation
Molybdopterin guanylyltransferaseUniRule annotation
Molybdopterin-guanine dinucleotide synthaseUniRule annotation
Short name:
MGD synthaseUniRule annotation
Gene namesi
Name:mobAUniRule annotation
Ordered Locus Names:RL2729
OrganismiRhizobium leguminosarum bv. viciae (strain 3841)
Taxonomic identifieri216596 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
Proteomesi
  • UP000006575 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001329611 – 209Molybdenum cofactor guanylyltransferaseAdd BLAST209

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi216596.RL2729.

Structurei

3D structure databases

ProteinModelPortaliQ1MFQ6.
SMRiQ1MFQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.UniRule annotation

Sequence similaritiesi

Belongs to the MobA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6R. Bacteria.
COG0746. LUCA.
HOGENOMiHOG000280423.
KOiK03752.
OMAiIFVMAAP.
OrthoDBiPOG091H05CW.

Family and domain databases

CDDicd02503. MobA. 1 hit.
Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00316. MobA. 1 hit.
InterProiView protein in InterPro
IPR025877. MobA-like_NTP_Trfase.
IPR013482. Molybde_CF_guanTrfase.
IPR029044. Nucleotide-diphossugar_trans.
PfamiView protein in Pfam
PF12804. NTP_transf_3. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR02665. molyb_mobA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1MFQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEFSLDKSH IAGVVLAGGR SQRMGRDKAG VMLGAESLLR HALTRLSQQA
60 70 80 90 100
LHVAVNADAA AEDVPVVPDR FPGKAGPMAG IHAAMVYAAD LPSITHVVTV
110 120 130 140 150
SVDCPFFPAD LVARLAAAIE HPSQIAIAAS EGRSHPVFGL WPVTLAADLE
160 170 180 190 200
AWIATDEKRR VRDFLLRHDV TEVAFPLHPT RASLLDPFFN INTPDDLVEA

ERWLEALRA
Length:209
Mass (Da):22,534
Last modified:May 30, 2006 - v1
Checksum:i359E602133E99C7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM236080 Genomic DNA. Translation: CAK08218.1.
RefSeqiWP_011652261.1. NC_008380.1.

Genome annotation databases

EnsemblBacteriaiCAK08218; CAK08218; RL2729.
KEGGirle:RL2729.

Similar proteinsi

Entry informationi

Entry nameiMOBA_RHIL3
AccessioniPrimary (citable) accession number: Q1MFQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 30, 2006
Last modified: January 31, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome