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Protein

cAMP-responsive element modulator

Gene

CREM

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Isoform 1 and isoform 2 are transcriptional activators. Plays a role in spermatogenesis and is involved in spermatid maturation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-responsive element modulator
Gene namesi
Name:CREM
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Organism-specific databases

VGNCiVGNC:27706 CREM

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002863571 – 360cAMP-responsive element modulatorAdd BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei118PhosphoserineBy similarity1
Modified residuei145PhosphoserineBy similarity1
Modified residuei287PhosphoserinePROSITE-ProRule annotationBy similarity1
Modified residuei290PhosphoserinePROSITE-ProRule annotationBy similarity1
Modified residuei293PhosphoserinePROSITE-ProRule annotationBy similarity1

Post-translational modificationi

Stimulated by phosphorylation. Phosphorylated on Ser-118 by TSSK4 in vitro.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ1LZH5

Expressioni

Gene expression databases

BgeeiENSBTAG00000016060 Expressed in 10 organ(s), highest expression level in testis

Interactioni

Subunit structurei

Binds DNA as a dimer. Interacts with FHL5. Interacts with CDC34. May interact with TSSK4.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021381

Structurei

3D structure databases

SMRiQ1LZH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 163KIDPROSITE-ProRule annotationAdd BLAST60
Domaini302 – 360bZIPPROSITE-ProRule annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni303 – 328Basic motifPROSITE-ProRule annotationAdd BLAST26
Regioni330 – 351Leucine-zipperPROSITE-ProRule annotationAdd BLAST22

Sequence similaritiesi

Belongs to the bZIP family.Curated

Phylogenomic databases

eggNOGiKOG3584 Eukaryota
ENOG410ZZJZ LUCA
GeneTreeiENSGT00390000008655
HOGENOMiHOG000007365
HOVERGENiHBG011077
InParanoidiQ1LZH5
KOiK09052
OMAiESAHMQT
OrthoDBiEOG091G0FTJ
TreeFamiTF106464

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR003102 Coactivator_CBP_pKID
IPR001630 Leuzip_CREB
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PF02173 pKID, 1 hit
PRINTSiPR00041 LEUZIPPRCREB
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit
PS50953 KID, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage. AlignAdd to basket
Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q1LZH5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKCGRKKYM KTNLRQMTME TIDSQQDGSL PDSVAESESA HMQTQTGQNS
60 70 80 90 100
IPTLAQVSVA GSSTGRGSPA VTLVQLPSGQ TVHVQGVIQT PQPSVIQSPQ
110 120 130 140 150
IQTVQVATIA ETDESAESEG VIDSHKRREI LSRRPSYRKI LNELSSDVPG
160 170 180 190 200
VPKIEEEKSE EEGTPPNIAA MAVPTSIYQT STGQYIAIAQ GGTIQISNPG
210 220 230 240 250
SDGVQGLQAL TMTNSGAPPP GATIVQYAAQ SADGTQQFFV PGSQVVVQDE
260 270 280 290 300
ETELAPSHMA AATGDMPTYQ IRAPTTALPQ GVVMAASPGS LHSPQQLAEE
310 320 330 340 350
ATRKRELRLM KNREAAKECR RRKKEYVKCL ESRVAVLEVQ NKKLIEELET
360
LKDICSPKTD
Note: Produced by alternative promoter usage. Activator.
Length:360
Mass (Da):38,694
Last modified:September 22, 2009 - v3
Checksum:i78C5E242D95536DE
GO
Isoform 2 (identifier: Q1LZH5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: Missing.
     56-56: Q → M

Note: Produced by alternative promoter usage. Activator.
Show »
Length:305
Mass (Da):32,623
Checksum:iB430A1A7238DE401
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti249D → G in AAI02678 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0250331 – 55Missing in isoform 2. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_02503456Q → M in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102677 mRNA Translation: AAI02678.1
BC115995 mRNA Translation: AAI15996.1
RefSeqiNP_001029882.2, NM_001034710.3 [Q1LZH5-1]
XP_005214310.1, XM_005214253.3 [Q1LZH5-2]
UniGeneiBt.48141

Genome annotation databases

EnsembliENSBTAT00000021381; ENSBTAP00000021381; ENSBTAG00000016060 [Q1LZH5-1]
ENSBTAT00000055517; ENSBTAP00000050114; ENSBTAG00000016060 [Q1LZH5-2]
GeneIDi540605
KEGGibta:540605

Keywords - Coding sequence diversityi

Alternative promoter usage

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102677 mRNA Translation: AAI02678.1
BC115995 mRNA Translation: AAI15996.1
RefSeqiNP_001029882.2, NM_001034710.3 [Q1LZH5-1]
XP_005214310.1, XM_005214253.3 [Q1LZH5-2]
UniGeneiBt.48141

3D structure databases

SMRiQ1LZH5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021381

Proteomic databases

PaxDbiQ1LZH5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000021381; ENSBTAP00000021381; ENSBTAG00000016060 [Q1LZH5-1]
ENSBTAT00000055517; ENSBTAP00000050114; ENSBTAG00000016060 [Q1LZH5-2]
GeneIDi540605
KEGGibta:540605

Organism-specific databases

CTDi1390
VGNCiVGNC:27706 CREM

Phylogenomic databases

eggNOGiKOG3584 Eukaryota
ENOG410ZZJZ LUCA
GeneTreeiENSGT00390000008655
HOGENOMiHOG000007365
HOVERGENiHBG011077
InParanoidiQ1LZH5
KOiK09052
OMAiESAHMQT
OrthoDBiEOG091G0FTJ
TreeFamiTF106464

Gene expression databases

BgeeiENSBTAG00000016060 Expressed in 10 organ(s), highest expression level in testis

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR003102 Coactivator_CBP_pKID
IPR001630 Leuzip_CREB
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PF02173 pKID, 1 hit
PRINTSiPR00041 LEUZIPPRCREB
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit
PS50953 KID, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCREM_BOVIN
AccessioniPrimary (citable) accession number: Q1LZH5
Secondary accession number(s): Q3SZW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: September 22, 2009
Last modified: October 10, 2018
This is version 82 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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