UniProtKB - Q1LZ86 (ABHD6_BOVIN)
Protein
Monoacylglycerol lipase ABHD6
Gene
ABHD6
Organism
Bos taurus (Bovine)
Status
Functioni
Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (By similarity). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (By similarity).By similarity
Catalytic activityi
- 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H+By similarity
- 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H+By similarity
- Hydrolyzes glycerol monoesters of long-chain fatty acids.By similarity EC:3.1.1.23
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 148 | NucleophileBy similarity | 1 | |
Active sitei | 278 | Charge relay systemBy similarity | 1 | |
Active sitei | 306 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- acylglycerol lipase activity Source: UniProtKB
- phospholipase activity Source: GO_Central
GO - Biological processi
- acylglycerol catabolic process Source: UniProtKB
- long-term synaptic depression Source: Ensembl
- lysobisphosphatidic acid metabolic process Source: UniProtKB
- monoacylglycerol catabolic process Source: UniProtKB
- negative regulation of cell migration Source: Ensembl
- negative regulation of cold-induced thermogenesis Source: Ensembl
- phospholipid catabolic process Source: Ensembl
- positive regulation of lipid biosynthetic process Source: Ensembl
- regulation of endocannabinoid signaling pathway Source: Ensembl
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid metabolism |
Enzyme and pathway databases
Reactomei | R-BTA-426048, Arachidonate production from DAG |
Protein family/group databases
ESTHERi | bovin-q1lz86, ABHD6-Lip |
Names & Taxonomyi
Protein namesi | Recommended name: Monoacylglycerol lipase ABHD6Curated (EC:3.1.1.23By similarity)Alternative name(s): 2-arachidonoylglycerol hydrolaseBy similarity Abhydrolase domain-containing protein 6By similarity |
Gene namesi | Name:ABHD6By similarity |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:25503, ABHD6 |
Subcellular locationi
Lysosome
- Lysosome membrane By similarity; Single-pass type II membrane protein Sequence analysis
Mitochondrion
- Mitochondrion membrane By similarity; Single-pass type II membrane protein Sequence analysis
Endosome
- Late endosome membrane By similarity; Single-pass type II membrane protein Sequence analysis
Endosome
- late endosome membrane Source: UniProtKB
Lysosome
- lysosomal membrane Source: UniProtKB
Mitochondrion
- mitochondrial membrane Source: UniProtKB-SubCell
- mitochondrion Source: GO_Central
Plasma Membrane
- AMPA glutamate receptor complex Source: Ensembl
Other locations
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 19 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 20 – 42 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 23 | |
Topological domaini | 43 – 337 | CytoplasmicSequence analysisAdd BLAST | 295 |
Keywords - Cellular componenti
Endosome, Lysosome, Membrane, MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000281574 | 1 – 337 | Monoacylglycerol lipase ABHD6Add BLAST | 337 |
Proteomic databases
PaxDbi | Q1LZ86 |
PRIDEi | Q1LZ86 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000016615, Expressed in placenta and 19 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 72 – 313 | AB hydrolase-1Sequence analysisAdd BLAST | 242 |
Sequence similaritiesi
Belongs to the AB hydrolase superfamily.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1454, Eukaryota |
GeneTreei | ENSGT00510000047225 |
HOGENOMi | CLU_020336_13_9_1 |
InParanoidi | Q1LZ86 |
OMAi | AYYPSDI |
OrthoDBi | 1285824at2759 |
TreeFami | TF331946 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR000073, AB_hydrolase_1 |
Pfami | View protein in Pfam PF00561, Abhydrolase_1, 1 hit |
PRINTSi | PR00111, ABHYDROLASE |
SUPFAMi | SSF53474, SSF53474, 1 hit |
i Sequence
Sequence statusi: Complete.
Q1LZ86-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLDVVNMFV IAGGTLALPI LAFVASFLLW PSALIRIYYW YWRRTLGMQV
60 70 80 90 100
RYVRHEDYQF CYSFRGRPGH KPSILMLHGF SAHKDMWLSM VKFLPKNLHL
110 120 130 140 150
VCVDMPGHEG TTRSSLDDLS IDGQVKRIHQ FVECLKLNKK PFHLVGTSMG
160 170 180 190 200
GHVAGVYAAH YPSDVCSLSL VCPAGLQYST DNKFVQRLKE LQESAAVEKI
210 220 230 240 250
PLIPTTPKEM SEMLQLCSYV RFKVPQQILQ GLVDVRIPHN TFYRKLFLEI
260 270 280 290 300
VSEKSRYSLH QNMDKIKVPT QIIWGKQDQV LDVSGADMLA KSIANSQVEL
310 320 330
LENCGHSVVM ERPRKTAKLL VDFLASVHST DNSKKLD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC116144 mRNA Translation: AAI16145.1 |
RefSeqi | NP_001068664.1, NM_001075196.1 XP_005222787.1, XM_005222730.3 XP_005222789.1, XM_005222732.3 |
Genome annotation databases
Ensembli | ENSBTAT00000022100; ENSBTAP00000022100; ENSBTAG00000016615 |
GeneIDi | 505283 |
KEGGi | bta:505283 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC116144 mRNA Translation: AAI16145.1 |
RefSeqi | NP_001068664.1, NM_001075196.1 XP_005222787.1, XM_005222730.3 XP_005222789.1, XM_005222732.3 |
3D structure databases
SMRi | Q1LZ86 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000022100 |
Protein family/group databases
ESTHERi | bovin-q1lz86, ABHD6-Lip |
Proteomic databases
PaxDbi | Q1LZ86 |
PRIDEi | Q1LZ86 |
Genome annotation databases
Ensembli | ENSBTAT00000022100; ENSBTAP00000022100; ENSBTAG00000016615 |
GeneIDi | 505283 |
KEGGi | bta:505283 |
Organism-specific databases
CTDi | 57406 |
VGNCi | VGNC:25503, ABHD6 |
Phylogenomic databases
eggNOGi | KOG1454, Eukaryota |
GeneTreei | ENSGT00510000047225 |
HOGENOMi | CLU_020336_13_9_1 |
InParanoidi | Q1LZ86 |
OMAi | AYYPSDI |
OrthoDBi | 1285824at2759 |
TreeFami | TF331946 |
Enzyme and pathway databases
Reactomei | R-BTA-426048, Arachidonate production from DAG |
Gene expression databases
Bgeei | ENSBTAG00000016615, Expressed in placenta and 19 other tissues |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR000073, AB_hydrolase_1 |
Pfami | View protein in Pfam PF00561, Abhydrolase_1, 1 hit |
PRINTSi | PR00111, ABHYDROLASE |
SUPFAMi | SSF53474, SSF53474, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ABHD6_BOVIN | |
Accessioni | Q1LZ86Primary (citable) accession number: Q1LZ86 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | May 30, 2006 | |
Last modified: | December 2, 2020 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families